The impact of irritable bowel syndrome on health-related quality of life in women with polycystic ovary syndrome

The objectives of this study were to compare the prevalence and quality of life (QOL) of irritable bowel syndrome (IBS) in women with polycystic ovary syndrome (PCOS) compared with healthy women.Methods This was a case-control study of 201 women recruited at an infertility clinic in Iran. The control group were healthy women (n=100) and the comparison group, women with PCOS (n=101). Data were collected by clinical Rome III criteria to determine the IBS, Bristol scale for stool consistency and IBS QOL.Results The reporting of IBS symptoms was higher in PCOS (20.7%) than control group (11%) (P=0.05). Predictive factors of IBS included having diagnosed PCOS (OR: 1.61; CI: 0.71–2.11) and an increase of LH/FSH (OR: 1.09; 0.95 CI: (0.83-1.45). The IBS QOL score in the IBS+PCOS group was lower than other groups (IBS+ non PCOS, non IBS+PCOS, non IBS+ non PCOS; scores in food avoidance and worries about health domains were significant (P<0.01). Conclusions: We conclude that having PCOS and an increased level of LH/FSH tends to cause IBS symptoms. IBS+PCOS women experience significant impaired quality of life scores particularly in relation to worries about health and food avoidance. These results offer further insights into IBS in PCOS women and their functional status and wellbeing.