PHENYL SULFAMATE DERIVATIVES
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Abstract
Phenyl sulfamate derivatives represented by the following formula or salts thereof have a powerful inhibitory effect on steroid sulfatase and are hence useful for the prophylaxis or treatment of diseases associated with steroids such as estrogens, such as breast cancer, corpus uteri cancer, endometrial hyperplasia, infertility, endometriosis, adenomyosis uteri, autoimmune disease, dementia or Alzheimer's disease. wherein R and R each independently represent a hydrogen atom or a lower alkyl group; R represents a hydrogen atom, a halogen atom, a lower alkyl group, -OSO2NRR, a lower alkanoylamino group, a nitro group or a cyano group; and A represents a substituted or unsubstituted phenyl group, a group of the formula -X-NRR, or the like.
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- europepmc
- last seen: 2026-07-07T06:07:59.301721+00:00