After the FLUSH trial: A prospective observational study of lipiodol flushing as an innovative treatment for unexplained and endometriosis‐related infertility

Kira Brent, W.E. Hadden, Wendy E Hadden, Marianne WESTON‐WEBB, Marianne Weston-Webb, Neil Johnson, Neil P Johnson
The Australian & New Zealand journal of obstetrics & gynaecology · 2006 · vol. 46(4) , pp. 293–297 · doi:10.1111/j.1479-828x.2006.00595.x · PMID:16866789 · W2081719801
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This prospective study found lipiodol flushing treatment achieved a 30% pregnancy rate and 27% live birth/ongoing pregnancy rate in 100 infertile women, with no complications reported.

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Abstract

OBJECTIVES: To assess the demographics, efficacy and safety of lipiodol flushing fertility treatment. DESIGN: Prospective observational study. SETTING: Secondary level care infertility clinic and radiology centre based in Auckland, New Zealand. POPULATION: The first cohort of 100 New Zealand women with infertility to undergo lipiodol flushing as an innovative fertility treatment. METHODS: Women received lipiodol flushing performed by a hysterosalpingogram technique and were followed up at 6 months. MAIN OUTCOME MEASURES: Clinical pregnancy at 6 months post-treatment; and live birth or ongoing pregnancy. RESULTS: The overall pregnancy rate was 30% and the live birth or ongoing pregnancy rate 27%. For women under 40 years old, a 32% pregnancy rate and a 25% live birth or ongoing pregnancy rate were seen in women with unexplained infertility, and a 50% pregnancy rate and a 47% live birth or ongoing pregnancy rate were seen in women with endometriosis. Of women aged 40 years and older, the pregnancy rate was 13% and the live birth or ongoing pregnancy rate was 13%. The pregnancy rates included those occurring after additional interventions, such as intrauterine insemination and in vitro fertilisation, accounting for 12 of the 30 pregnancies. There were no treatment complications. CONCLUSION: This study provides further evidence of the efficacy and safety of lipiodol flushing fertility treatment.

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Condition tags

endometriosisinfertility

MeSH descriptors

Contrast Media Endometriosis Fallopian Tube Diseases Fallopian Tubes Infertility, Female Iodized Oil Adult Cohort Studies Contrast Media Endometriosis Fallopian Tube Diseases Female Humans Hysterosalpingography Infertility, Female Iodized Oil Middle Aged Pregnancy Pregnancy Rate Prospective Studies

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