Silenced fatty acid-binding protein 4 suppresses epithelial-mesenchymal transition of endometriosis via the phosphatidyl inositol 3-kinase/protein kinase B axis

Yan-Chu-Fei Zhang; Zhang Y; Y Zhang; A Hou; Hou A; Zhuang XR; X R Zhuang; X J Gao; Gao XJ; Zhang GX; G X Zhang

doi:10.23812/21-36-l

Silenced fatty acid-binding protein 4 suppresses epithelial-mesenchymal transition of endometriosis via the phosphatidyl inositol 3-kinase/protein kinase B axis

Yan-Chu-Fei Zhang, Zhang Y, Y Zhang, A Hou, Hou A, Zhuang XR, X R Zhuang, X J Gao, Gao XJ, Zhang GX, G X Zhang

Journal of biological regulators and homeostatic agents · 2021 · vol. 35(4) · doi:10.23812/21-36-l · PMID:34281297 · W3186779430

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⚙ AI-generated summary by gemini-2.5-flash-lite+body, 2026-08-02 ⓘ

Silenced fatty acid-binding protein 4 suppresses epithelial-mesenchymal transition, invasion, and migration of endometriosis by acting through the PI3K/AKT axis.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-14 · read from full text ⓘ

This study investigated the role of fatty acid-binding protein 4 (FABP4) in the progression of endometriosis, specifically focusing on its influence on epithelial-mesenchymal transition. The researchers demonstrated that silencing FABP4 inhibits this transition process by modulating the phosphatidyl inositol 3-kinase/protein kinase B signaling axis. These findings indicate that FABP4 acts as a promoter of invasion and migration in endometriotic cells through these specific molecular pathways. This paper is centrally about endometriosis — specifically the molecular mechanisms driving epithelial-mesenchymal transition via the PI3K/AKT axis.

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Keywords

PI3K/AKT axis;endometriosis;epithelial-mesenchymal transition;fatty acid-binding protein 4;invasion;migration

References

Supporting Agencies Copyright (c) 2021 Y Zhang, A Hou, XR Zhuang, XJ Gao, GX Zhang This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). Editor-in-Chief Medical Genetics, University of Torino Medical School, Italy Co-Editor-in-Chief Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy Indexing & Archiving News & Announcements 2026-02-09 Journal of Biological Regulators and Homeostatic Agents (JBRHA, Print ISSN: 0393-974X, Electronic ISSN: 1724-6083) has officially transitioned to China Scientific Research Publishing, taking over publication from Asia Pacific Academy of Science Pte. Ltd. with effect from Vol 40, No 1 (2026). All new submissions should be made via the new journal website at https://journal.csrp-pub.com/index.php/jbrha from February 10, 2026. For any inquiries regarding this transition and the publication of manuscripts being processed, please contact the new publisher at [email protected] or [email protected]. 2025-02-01 In addition to the first issue that has already been published by the original publisher, there will be four more issues released this year, with scheduled publication dates in March, June, September, and December respectively. 2025-01-21 Starting from Volume 39 Issue 2 (2025), the ownership of Journal of Biological Regulators and Homeostatic Agents (ISSN: 0393-974X (P); 1724-6083 (O)) will be transferred from Biolife Sas to Asia Pacific Academy of Science Pte. Ltd. As of 21 January 2025, authors should make submissions to the new journal system and follow the author guidelines. Asia Pacific Academy of Science Pte. Ltd. will take over the publication of manuscripts being processed.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-akt Cell Line, Tumor Cell Movement Cell Proliferation Epithelial-Mesenchymal Transition Fatty Acid-Binding Proteins Fatty Acid-Binding Proteins Female Humans Neoplasm Invasiveness Phosphatidylinositol 3-Kinase Phosphatidylinositols

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europepmc: last seen: 2026-08-22T06:09:51.966504+00:00
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