Effect of bacterial secretomes isolated from larval food of Frieseomelitta varia on Drosophila melanogaster model for Azheimer's Disease

Abstract Alzheimer's disease (AD) is the most prevalent neurodegenerative pathology in Brazil. It is associated with age and cognitive and neuropsychiatric manifestations, which result in progressive and disabling disability. It is responsible for 60–70% of dementia cases with an estimated increase of 10 million diagnoses annually. Research in AD suggests that the imbalance between the production and elimination of amyloid beta (Aβ) (amyloid hypothesis) is responsible for events that lead to AD. The present study investigated the neuroprotective effect and inhibitory activity of the bacterial secretome isolated from the larval food of the stingless bee Frieseomelitta varia in a transgenic line of Drosophila melanogaster, a model for the study of AD. This has been an important model organism for research into the events involved in AD. DA model flies were treated with different bacterial secretomes for 15 days after eclosion. Secretomes identified as S27 and S40 improved the climbing rate of these flies, assessed through Rapid Interactive Negative Geotaxis (RING). Histological analysis of the brain revealed potential for decreased neurodegeneration. Therefore, the bacterial secretome isolated from stingless bee larval food showed potential as a source of bioactive molecules to reduce the neurodegeneration process in AD.