Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain

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Hodnett" }, { "@type": "Person", "name": "Berrylin Ferguson" } ], "publisher": { "@type": "Organization", "name": "F1000Research", "logo": { "@type": "ImageObject", "url": "https://f1000research.com/img/AMP/F1000Research_image.png", "height": 480, "width": 60 } }, "image": { "@type": "ImageObject", "url": "https://f1000research.com/img/AMP/F1000Research_image.png", "height": 1200, "width": 150 }, "description": "Dental sources of infection can produce acute and chronic maxillary sinusitis. In some cases, the source of the infection may be related to the presence of endodontic materials in the oral cavity. In this article, we report a case of retained gutta-percha in the maxillary sinus resulting in chronic sinusitis." } { "@context": "http://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": "1", "item": { "@id": "https://f1000research.com/", "name": "Home" } }, { "@type": "ListItem", "position": "2", "item": { "@id": "https://f1000research.com/browse/articles", "name": "Browse" } }, { "@type": "ListItem", "position": "3", "item": { "@id": "https://f1000research.com/articles/3-81/v2/iparadigms", "name": "Case Report: retained gutta-percha as a cause for persistent maxillary..." } } ] } Home Browse Case Report: retained gutta-percha as a cause for persistent maxillary... ALL Metrics - Views Downloads Get PDF Get XML Cite How to cite this article Hodnett BL and Ferguson B. Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.12688/f1000research.3791.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. Close Copy Citation Details Export Export Citation Sciwheel EndNote Ref. Manager Bibtex ProCite Sente EXPORT Select a format first Track Share ▬ ✚ Case Report Revised Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] Benjamin L. Hodnett 1 , Berrylin Ferguson 2 Benjamin L. Hodnett 1 , Berrylin Ferguson 2 PUBLISHED 29 Apr 2014 Author details Author details 1 Department of Otolaryngology, University of Pittsburgh Medical Center Eye and Ear Institute, Pittsburgh, PA, 15213, USA 2 Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA, 15219, USA OPEN PEER REVIEW DETAILS REVIEWER STATUS Abstract Dental sources of infection can produce acute and chronic maxillary sinusitis. In some cases, the source of the infection may be related to the presence of endodontic materials in the oral cavity. In this article, we report a case of retained gutta-percha in the maxillary sinus resulting in chronic sinusitis. READ ALL READ LESS Corresponding Author(s) Berrylin Ferguson ( [email protected] ) Close Corresponding author: Berrylin Ferguson Competing interests: No competing interests were declared. Grant information: The author(s) declared that no grants were involved in supporting this work. Copyright: © 2014 Hodnett BL and Ferguson B. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication). How to cite: Hodnett BL and Ferguson B. Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.12688/f1000research.3791.2 ) First published: 31 Mar 2014, 3 :81 ( https://doi.org/10.12688/f1000research.3791.1 ) Latest published: 29 Apr 2014, 3 :81 ( https://doi.org/10.12688/f1000research.3791.2 ) Revised Amendments from Version 1 The major change made in the second version of the paper was the inclusion of new figures 2-4. I made figures with an inset to highlight the retained gutta-percha more clearly. I also included a comment regarding the lack of pathological specimen. Based on the surgical procedure, the gutta-percha had to be drilled out of the maxillary bone, and thus there was no specimen for analysis. The major change made in the second version of the paper was the inclusion of new figures 2-4. I made figures with an inset to highlight the retained gutta-percha more clearly. I also included a comment regarding the lack of pathological specimen. Based on the surgical procedure, the gutta-percha had to be drilled out of the maxillary bone, and thus there was no specimen for analysis. See the authors' detailed response to the review by Rakesh K Chandra See the authors' detailed response to the review by Alkis Psaltis READ REVIEWER RESPONSES Introduction Foreign bodies in soft tissues can often occur as a result of trauma. There are multiple case reports in the otolaryngology literature of projectiles that have become lodged in the paranasal sinuses 1 . Retained packing gauze from endoscopic sinus surgery has also been reported in the paranasal sinuses 2 . In the endodontic literature, many reports and reviews have described various materials that can cause disease of the maxillary sinuses 3 . In this case report, we present an interesting case of a patient who presented with recalcitrant maxillary sinusitis that was ultimately found to be related to retained endodontic material in her maxillary sinus. Case report A 26-year-old Caucasian woman presented with a chief complaint of left-sided maxillary pain with intermittent, discoloured nasal drainage. Seven years prior to current presentation, the patient had reported a history of headaches, nasal congestion and bilateral discolored drainage refractory to prednisone, antibiotics, and endoscopic sinus surgery at an outside facility. Revision endoscopic sinus surgery one year after the initial surgery provided partial relief. Two years prior to current presentation, her left maxillary pain recurred, and a computed tomography (CT) scan revealed a left wisdom tooth projecting into her maxillary sinus. Following wisdom teeth extraction, she had marked improvement in pain and nasal drainage; however 8 weeks later, left maxillary pain returned and was associated with left-sided yellow nasal discharge. Her oral surgeon discovered an infection in the molar adjacent to the extracted wisdom tooth and performed a root canal. Two weeks following the root canal, she presented with continued left maxillary tooth pain and left-sided discolored nasal discharge. Extraction of the molar failed to resolve her pain, and she was subsequently referred to the facial pain/headache clinic by her dentist where she was prescribed gabapentin 300 mg TID, which was ineffective. Her dentist also prescribed her multiple courses of clindamycin 150 mg TID and guaifenesin 600 gm QID, which would improve her pain and discoloured drainage. However, her symptoms would return after completing the antibiotics. On examination with rigid endoscopy, she had widely patent maxillary, ethmoid, and frontal sinus ostia with no purulence or polyposis. On flexible endoscopic examination of the floor of her left maxillary sinus, white to slightly yellow mucus was found. Aspiration of the mucus relieved the patient’s discomfort. Maxillary sinus cultures revealed few polymorphonuclear leukocytes, few mononuclear cells, and no microorganisms. Her most recent CT scan from two years prior to presentation at our facility was remarkable for minimal mucosal thickening of the floor of the left maxillary sinus was otherwise normal ( Figure 1 ). An occult dental infection was considered high in the differential diagnosis; however, because no actual dental infection could be demonstrated, a medial maxillectomy was considered in order to facilitate topical washing of the left maxillary sinus. Follow-up appointments in the facial pain/headache clinic found “some features of migraine, but it is unclear whether headaches represent primary or secondary headaches with migraine features”. Repeat evaluations by her dentist found no evidence of a dental infection. Because of past improvement on an 8-week course of clindamycin 300 mg TID, she was prescribed a 12-week course of clindamycin 300 mg TDI before surgery was considered, and she was referred to an infectious disease specialist. Figure 1. Non-contrasted coronal CT scan from two years prior to patient presentation. Only mild mucosal thickening of the floor of the left maxillary sinus and post-surgical changes related to endoscopic sinus surgery were noted. Clindamycin initially improved her symptoms, but midway through the course her congestion returned. A bone scan was positive in the region of the left maxilla; however, a repeat indium scan was negative. Her CT scan was repeated and she was referred to an oral surgeon for evaluation ( Figure 2 – Figure 4 ). Figure 2. Repeat non-contrasted coronal CT scan. Retained gutta-percha (white arrow) noted in left maxillary sinus. Inset in the top right corner reveals a zoomed image of the gutta-percha. Figure 3. Axial section of non-contrasted CT scan shows two retained remnants of gutta-percha (white arrow) in the left posterior maxillary sinus. Inset in the top-right corner reveals a zoomed image of the two gutta-percha remnants. Figure 4. Sagittal section of non-contrasted CT scan shows two retained remnants of gutta-percha (white arrow) in the left maxilla in the location of previous dental extractions. Inset in the top-right corner reveals a zoomed image of the two gutta-percha remnants. The CT scan was evaluated by an oral and maxillofacial surgeon who noted that there were two small remnants of the prior left maxillary root canal that had been performed two and half years ago ( Figure 2 – Figure 4 ). A combined endoscopic and Caldwell-Luc approach under computer-assisted navigation to drill out retained gutta-percha in the maxillary sinus resolved the patient’s pain and drainage immediately, without recurrence at her three month follow-up. No pathological specimens were available for analysis as the gutta-percha remnants were drilled out during the surgery. Discussion Gutta-percha, a product of tropical rubber plants, has been used since the mid-1800s as an endodontic filling material following root canal procedures 4 . The chemical structure of gutta-percha is a trans-isomer of poly-isoprene, or natural rubber; however it is more crystalline than natural rubber and often is formulated with medications such as zinc oxide, iodoform, chlorhexidine and calcium hydroxide, which contribute to both the antibacterial and antifungal activity 4 – 7 . Animal studies have shown that gutta-percha becomes encapsulated by fibrous connective tissue with little inflammatory reaction 8 . Maxillary sinus complications from gutta-percha from root canals are rare. According to a previous case report, gutta-percha from a maxillary tooth root canal can migrate to and obstruct the maxillary ostium 9 . Gutta-percha has also been reported to migrate into the ethmoid sinus 10 . In the current patient, retained gutta-percha in the maxillary sinus resulted in chronic inflammation and a persistent sinusitis-type picture with nasal congestion, pain and drainage. Her symptoms preceding the sinus surgery may or may not have been related to dental infection, but she clearly improved following wisdom teeth extraction, and she relapsed due to the infection of the adjacent molar. The retained gutta-percha prevented the resolution of infection and symptoms, even following extraction of the affected tooth. Partial improvement with antibiotics directed to usual dental pathogens provided some evidence that the etiology of her symptoms was a dental infection. In patients with persistent sinusitis and a history of endodontic procedures, an evaluation for dental materials retained in or near the sinuses may be warranted to rule out an additional source of infection. Removal of these retained dental materials may require an external approach with drilling, which can be facilitated by endoscopic visualization through the Caldwell-Luc procedure. A review of the otolaryngology literature did not provide any additional case reports on retained gutta-percha. In fact, only two case reports were found in the oral and maxillofacial surgery literature that described retained gutta-percha in the paranasal sinuses. In the oral surgery and endodontic literature, there are multiple reports of aspergillosis occurring in the maxillary sinus as a result of overextension of root canals of maxillary teeth, especially using materials containing zinc oxide or formaldehyde 3 , 11 . One case series of aspergillosis of the maxillary sinus was found in the otolaryngology literature. In this series, 85 cases of aspergillosis of the maxillary sinus in non-immunosuppressed patients were reviewed. Of these, 94% presented evidence of a radio-opaque foreign body in the maxillary sinus, with 85% of the cases related to endodontic dental paste 12 . Our case report highlights the importance of investigating alternative sources of infection in cases of recalcitrant sinusitis. Dental sources of infection as well as retained or overextended endodontic materials should be investigated in patients with unexplained, chronic sinusitis. Consent Written informed consent for publication of clinical details and clinical images was obtained from the patient. Author contributions Benjamin Hodnett wrote the manuscript. Berrylin Ferguson revised the manuscript. All authors approved the final manuscript for publication. Competing interests No competing interests were declared. Grant information The author(s) declared that no grants were involved in supporting this work. Faculty Opinions recommended References 1. Yarlagadda B, Jalisi S, Burke P, et al. : Retrieval of projectile foreign bodies from the paranasal sinuses and skull base. Am J Rhinol Allergy. 2012; 26 (3): 233–236. PubMed Abstract | Publisher Full Text 2. Gotwald TF, Sprinzl GM, Fischer H, et al. : Retained packing gauze in the ethmoidal sinuses after endonasal sinus surgery: CT and surgical appearances. AJR Am J Roentgenol. 2001; 177 (6): 1487–9. PubMed Abstract | Publisher Full Text 3. Hauman CH, Chandler NP, Tong DC: Endodontic implications of the maxillary sinus: a review. Int Endod J. 2002; 35 (2): 127–141. PubMed Abstract | Publisher Full Text 4. Friedman CM, Sandrik JL, Heuer MA, et al. : Composition and mechanical properties of gutta-percha endodontic points. J Dent Res. 1975; 54 (5): 921–925. PubMed Abstract | Publisher Full Text 5. Bodrumlu E, Alaçam T: The antimicrobial and antifungal activity of a root canal core material. J Am Dent Assoc. 2007; 138 (9): 1228–1232. PubMed Abstract | Publisher Full Text 6. Tanomaru JM, Pappen FG, Tanomaru Filho M, et al. : In vitro antimicrobial activity of different gutta-percha points and calcium hydroxide pastes. Braz Oral Res. 2007; 21 (1): 35–39. PubMed Abstract | Publisher Full Text 7. Bodrumlu E, Alaçam T: Evaluation of antimicrobial and antifungal effects of iodoform integrating gutta-percha. J Can Dent Assoc. 2006; 72 (8): 733. PubMed Abstract 8. Sugawara A, Nishiyama M, Kusama K, et al. : Histopathological reactions of calcium phosphate cement. Dent Mater J. 1992; 11 (1): 11–16. PubMed Abstract | Publisher Full Text 9. Costa F, Robiony M, Toro C, et al. : Endoscopically assisted procedure for removal of a foreign body from the maxillary sinus and contemporary endodontic surgical treatment of the tooth. Head Face Med. 2006; 2 : 37. PubMed Abstract | Publisher Full Text | Free Full Text 10. Ishikawa M, Mizuno T, Yamazaki Y, et al. : Migration of gutta-percha point from a root canal into the ethmoid sinus. Br J Oral Maxillofac Surg. 2004; 42 (1): 58–60. PubMed Abstract | Publisher Full Text 11. Giardino L, Pontieri F, Savoldi E, et al. : Aspergillus mycetoma of the maxillary sinus secondary to overfilling of a root canal. J Endod. 2006; 32 (7): 692–694. PubMed Abstract | Publisher Full Text 12. Legent F, Billet J, Beauvillain C, et al. : The role of dental canal fillings in the development of Aspergillus sinusitis. A report of 85 cases. Arch Otorhinolaryngol. 1989; 246 (5): 318–320. PubMed Abstract | Publisher Full Text Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 31 Mar 2014 ADD YOUR COMMENT Comment Author details Author details 1 Department of Otolaryngology, University of Pittsburgh Medical Center Eye and Ear Institute, Pittsburgh, PA, 15213, USA 2 Department of Otolaryngology, University of Pittsburgh Medical Center, Pittsburgh, PA, 15219, USA Competing interests No competing interests were declared. Grant information The author(s) declared that no grants were involved in supporting this work. Article Versions (2) version 2 Revised Published: 29 Apr 2014, 3:81 https://doi.org/10.12688/f1000research.3791.2 version 1 Published: 31 Mar 2014, 3:81 https://doi.org/10.12688/f1000research.3791.1 Copyright © 2014 Hodnett BL and Ferguson B. This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication). Download Export To Sciwheel Bibtex EndNote ProCite Ref. Manager (RIS) Sente metrics Views Downloads F1000Research - - PubMed Central info_outline Data from PMC are received and updated monthly. - - Citations open_in_new 0 open_in_new 0 open_in_new SEE MORE DETAILS CITE how to cite this article Hodnett BL and Ferguson B. Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.12688/f1000research.3791.2 ) NOTE: If applicable, it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS track receive updates on this article Track an article to receive email alerts on any updates to this article. TRACK THIS ARTICLE Share Open Peer Review Current Reviewer Status: ? Key to Reviewer Statuses VIEW HIDE Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Version 2 VERSION 2 PUBLISHED 29 Apr 2014 Revised Views 0 Cite How to cite this report: Platt MP. Reviewer Report For: Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.5256/f1000research.4326.r4889 ) The direct URL for this report is: https://f1000research.com/articles/3-81/v2#referee-response-4889 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 27 May 2014 Michael P. Platt , Department of Otolaryngology, Boston University School of Medicine, Boston, MA, USA Approved VIEWS 0 https://doi.org/10.5256/f1000research.4326.r4889 I confirm that I have read this submission and believe that I have an ... Continue reading READ ALL Competing Interests: No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Platt MP. Reviewer Report For: Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.5256/f1000research.4326.r4889 ) The direct URL for this report is: https://f1000research.com/articles/3-81/v2#referee-response-4889 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Psaltis A. Reviewer Report For: Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.5256/f1000research.4326.r4584 ) The direct URL for this report is: https://f1000research.com/articles/3-81/v2#referee-response-4584 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 29 Apr 2014 Alkis Psaltis , Department of Otolaryngology, Royal Adelaide Hospital, Adelaide, SA, Australia Approved VIEWS 0 https://doi.org/10.5256/f1000research.4326.r4584 Thank you for the additional images which are easier to follow and for the clarification ... Continue reading READ ALL Thank you for the additional images which are easier to follow and for the clarification on why there was an absence of radiological inflammation. This indeed is an interesting case report. Competing Interests: No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Psaltis A. Reviewer Report For: Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.5256/f1000research.4326.r4584 ) The direct URL for this report is: https://f1000research.com/articles/3-81/v2#referee-response-4584 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Version 1 VERSION 1 PUBLISHED 31 Mar 2014 Views 0 Cite How to cite this report: Platt MP. Reviewer Report For: Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.5256/f1000research.4060.r4315 ) The direct URL for this report is: https://f1000research.com/articles/3-81/v1#referee-response-4315 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 16 Apr 2014 Michael P. Platt , Department of Otolaryngology, Boston University School of Medicine, Boston, MA, USA Approved VIEWS 0 https://doi.org/10.5256/f1000research.4060.r4315 This is an interesting case that highlights the ... Continue reading READ ALL This is an interesting case that highlights the importance of identifying odontogenic causes for chronic maxillary sinusitis. Competing Interests: No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Platt MP. Reviewer Report For: Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.5256/f1000research.4060.r4315 ) The direct URL for this report is: https://f1000research.com/articles/3-81/v1#referee-response-4315 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Respond or Comment COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Psaltis A. Reviewer Report For: Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.5256/f1000research.4060.r4314 ) The direct URL for this report is: https://f1000research.com/articles/3-81/v1#referee-response-4314 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 09 Apr 2014 Alkis Psaltis , Department of Otolaryngology, Royal Adelaide Hospital, Adelaide, SA, Australia Approved with Reservations VIEWS 0 https://doi.org/10.5256/f1000research.4060.r4314 The value of single patient case reports to the scientific literature is debatable. Other than facilitating the documentation of rare conditions or experimental techniques, they are usually just articles of interest. Having said this, this well written article describing an ... Continue reading READ ALL The value of single patient case reports to the scientific literature is debatable. Other than facilitating the documentation of rare conditions or experimental techniques, they are usually just articles of interest. Having said this, this well written article describing an odontogenic cause of refractory left maxillary sinusitis does highlight the importance of a broad differential when treating patients with sinus symptoms. My only criticism is the imaging provided and its purpose. The arrows used to highlight the foreign material, particularly in the coronal CT scan, appear to be pointing into space. Furthermore, there is little evidence of mucosal inflammation or osteitis, that one would expect to see in a patient with a foreign body reaction with symptoms of nasal discharge. Nevertheless, the significant improvement the patient experienced on removal of the retained gutta-percha does suggest that this was indeed the underlying cause of her symptoms. Competing Interests: No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Psaltis A. Reviewer Report For: Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.5256/f1000research.4060.r4314 ) The direct URL for this report is: https://f1000research.com/articles/3-81/v1#referee-response-4314 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 11 Apr 2014 Benjamin Hodnett , Department of Otolaryngology, University of Pittsburgh Medical Center Eye and Ear Institute, Pittsburgh, PA, 15213, USA 11 Apr 2014 Author Response This CT scan was performed at the completion of an antibiotics course, which may explain the lack of inflammation. The radiology reports minimal inflammation as well. The patient had been ... Continue reading This CT scan was performed at the completion of an antibiotics course, which may explain the lack of inflammation. The radiology reports minimal inflammation as well. The patient had been on multiple courses of antibiotics with symptomatic improvement for a period of time after each treatment. The lack of osteitis is interesting. However, as stated in the discussion, gutta-percha in animals becomes encapsulated by fibrous connective tissue with little inflammatory response. The mechanism by which an encapsulated foreign body with little surrounding inflammation may precipitate a chronic sinus infection is indeed unusual. We will also provide additional images which should better illustrate the foreign material. This CT scan was performed at the completion of an antibiotics course, which may explain the lack of inflammation. The radiology reports minimal inflammation as well. The patient had been on multiple courses of antibiotics with symptomatic improvement for a period of time after each treatment. The lack of osteitis is interesting. However, as stated in the discussion, gutta-percha in animals becomes encapsulated by fibrous connective tissue with little inflammatory response. The mechanism by which an encapsulated foreign body with little surrounding inflammation may precipitate a chronic sinus infection is indeed unusual. We will also provide additional images which should better illustrate the foreign material. Competing Interests: None Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 11 Apr 2014 Benjamin Hodnett , Department of Otolaryngology, University of Pittsburgh Medical Center Eye and Ear Institute, Pittsburgh, PA, 15213, USA 11 Apr 2014 Author Response This CT scan was performed at the completion of an antibiotics course, which may explain the lack of inflammation. The radiology reports minimal inflammation as well. The patient had been ... Continue reading This CT scan was performed at the completion of an antibiotics course, which may explain the lack of inflammation. The radiology reports minimal inflammation as well. The patient had been on multiple courses of antibiotics with symptomatic improvement for a period of time after each treatment. The lack of osteitis is interesting. However, as stated in the discussion, gutta-percha in animals becomes encapsulated by fibrous connective tissue with little inflammatory response. The mechanism by which an encapsulated foreign body with little surrounding inflammation may precipitate a chronic sinus infection is indeed unusual. We will also provide additional images which should better illustrate the foreign material. This CT scan was performed at the completion of an antibiotics course, which may explain the lack of inflammation. The radiology reports minimal inflammation as well. The patient had been on multiple courses of antibiotics with symptomatic improvement for a period of time after each treatment. The lack of osteitis is interesting. However, as stated in the discussion, gutta-percha in animals becomes encapsulated by fibrous connective tissue with little inflammatory response. The mechanism by which an encapsulated foreign body with little surrounding inflammation may precipitate a chronic sinus infection is indeed unusual. We will also provide additional images which should better illustrate the foreign material. Competing Interests: None Close Report a concern COMMENT ON THIS REPORT Views 0 Cite How to cite this report: Chandra RK. Reviewer Report For: Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.5256/f1000research.4060.r4316 ) The direct URL for this report is: https://f1000research.com/articles/3-81/v1#referee-response-4316 NOTE: it is important to ensure the information in square brackets after the title is included in this citation. Close Copy Citation Details Reviewer Report 09 Apr 2014 Rakesh K Chandra , Department of Otolaryngology, Northwestern University, Chicago, Il, USA Approved VIEWS 0 https://doi.org/10.5256/f1000research.4060.r4316 An interesting case that creates awareness about odontogenic sources of maxillary sinusitis. the authors should describe any histopathology ... Continue reading READ ALL An interesting case that creates awareness about odontogenic sources of maxillary sinusitis. the authors should describe any histopathology findings - what type of inflammation was seen - eg neutrophilic, eosinophilic, histiocytes, foreign body giant cell, etc. Competing Interests: No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. Close READ LESS CITE CITE HOW TO CITE THIS REPORT Chandra RK. Reviewer Report For: Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.5256/f1000research.4060.r4316 ) The direct URL for this report is: https://f1000research.com/articles/3-81/v1#referee-response-4316 NOTE: it is important to ensure the information in square brackets after the title is included in all citations of this article. COPY CITATION DETAILS Report a concern Author Response 11 Apr 2014 Benjamin Hodnett , Department of Otolaryngology, University of Pittsburgh Medical Center Eye and Ear Institute, Pittsburgh, PA, 15213, USA 11 Apr 2014 Author Response No pathological specimen was available. The foreign material was embedded in the bone and drilled out by the oral surgeons. Competing Interests: None No pathological specimen was available. The foreign material was embedded in the bone and drilled out by the oral surgeons. No pathological specimen was available. The foreign material was embedded in the bone and drilled out by the oral surgeons. Competing Interests: None Close Report a concern Respond or Comment COMMENTS ON THIS REPORT Author Response 11 Apr 2014 Benjamin Hodnett , Department of Otolaryngology, University of Pittsburgh Medical Center Eye and Ear Institute, Pittsburgh, PA, 15213, USA 11 Apr 2014 Author Response No pathological specimen was available. The foreign material was embedded in the bone and drilled out by the oral surgeons. Competing Interests: None No pathological specimen was available. The foreign material was embedded in the bone and drilled out by the oral surgeons. No pathological specimen was available. The foreign material was embedded in the bone and drilled out by the oral surgeons. Competing Interests: None Close Report a concern COMMENT ON THIS REPORT Comments on this article Comments (0) Version 2 VERSION 2 PUBLISHED 31 Mar 2014 ADD YOUR COMMENT Comment keyboard_arrow_left keyboard_arrow_right Open Peer Review Reviewer Status info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Reviewer Reports Invited Reviewers 1 2 3 Version 2 (revision) 29 Apr 14 read read Version 1 31 Mar 14 read read read Rakesh K Chandra , Northwestern University, Chicago, Il, USA Alkis Psaltis , Royal Adelaide Hospital, Adelaide, SA, Australia Michael P. Platt , Boston University School of Medicine, Boston, MA, USA Comments on this article All Comments (0) Add a comment Sign up for content alerts Sign Up You are now signed up to receive this alert Browse by related subjects keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2014 Platt M. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 27 May 2014 | for Version 2 Michael P. Platt , Department of Otolaryngology, Boston University School of Medicine, Boston, MA, USA 0 Views copyright © 2014 Platt M. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Competing Interests No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Platt MP. Peer Review Report For: Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.5256/f1000research.4326.r4889) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/3-81/v2#referee-response-4889 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2014 Psaltis A. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 29 Apr 2014 | for Version 2 Alkis Psaltis , Department of Otolaryngology, Royal Adelaide Hospital, Adelaide, SA, Australia 0 Views copyright © 2014 Psaltis A. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions Thank you for the additional images which are easier to follow and for the clarification on why there was an absence of radiological inflammation. This indeed is an interesting case report. Competing Interests No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Psaltis A. Peer Review Report For: Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.5256/f1000research.4326.r4584) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/3-81/v2#referee-response-4584 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2014 Platt M. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 16 Apr 2014 | for Version 1 Michael P. Platt , Department of Otolaryngology, Boston University School of Medicine, Boston, MA, USA 0 Views copyright © 2014 Platt M. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (0) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions This is an interesting case that highlights the importance of identifying odontogenic causes for chronic maxillary sinusitis. Competing Interests No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (0) Platt MP. Peer Review Report For: Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.5256/f1000research.4060.r4315) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/3-81/v1#referee-response-4315 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2014 Psaltis A. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 09 Apr 2014 | for Version 1 Alkis Psaltis , Department of Otolaryngology, Royal Adelaide Hospital, Adelaide, SA, Australia 0 Views copyright © 2014 Psaltis A. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved With Reservations info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions The value of single patient case reports to the scientific literature is debatable. Other than facilitating the documentation of rare conditions or experimental techniques, they are usually just articles of interest. Having said this, this well written article describing an odontogenic cause of refractory left maxillary sinusitis does highlight the importance of a broad differential when treating patients with sinus symptoms. My only criticism is the imaging provided and its purpose. The arrows used to highlight the foreign material, particularly in the coronal CT scan, appear to be pointing into space. Furthermore, there is little evidence of mucosal inflammation or osteitis, that one would expect to see in a patient with a foreign body reaction with symptoms of nasal discharge. Nevertheless, the significant improvement the patient experienced on removal of the retained gutta-percha does suggest that this was indeed the underlying cause of her symptoms. Competing Interests No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above. reply Respond to this report Responses (1) Author Response 11 Apr 2014 Benjamin Hodnett, Department of Otolaryngology, University of Pittsburgh Medical Center Eye and Ear Institute, Pittsburgh, PA, 15213, USA This CT scan was performed at the completion of an antibiotics course, which may explain the lack of inflammation. The radiology reports minimal inflammation as well. The patient had been on multiple courses of antibiotics with symptomatic improvement for a period of time after each treatment. The lack of osteitis is interesting. However, as stated in the discussion, gutta-percha in animals becomes encapsulated by fibrous connective tissue with little inflammatory response. The mechanism by which an encapsulated foreign body with little surrounding inflammation may precipitate a chronic sinus infection is indeed unusual. We will also provide additional images which should better illustrate the foreign material. View more View less Competing Interests None reply Respond Report a concern Psaltis A. Peer Review Report For: Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.5256/f1000research.4060.r4314) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/3-81/v1#referee-response-4314 keyboard_arrow_left Back to all reports Reviewer Report 0 Views copyright © 2014 Chandra R. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 09 Apr 2014 | for Version 1 Rakesh K Chandra , Department of Otolaryngology, Northwestern University, Chicago, Il, USA 0 Views copyright © 2014 Chandra R. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. format_quote Cite this report speaker_notes Responses (1) Approved info_outline Alongside their report, reviewers assign a status to the article: Approved The paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. Not approved Fundamental flaws in the paper seriously undermine the findings and conclusions An interesting case that creates awareness about odontogenic sources of maxillary sinusitis. the authors should describe any histopathology findings - what type of inflammation was seen - eg neutrophilic, eosinophilic, histiocytes, foreign body giant cell, etc. Competing Interests No competing interests were disclosed. I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. reply Respond to this report Responses (1) Author Response 11 Apr 2014 Benjamin Hodnett, Department of Otolaryngology, University of Pittsburgh Medical Center Eye and Ear Institute, Pittsburgh, PA, 15213, USA No pathological specimen was available. The foreign material was embedded in the bone and drilled out by the oral surgeons. View more View less Competing Interests None reply Respond Report a concern Chandra RK. Peer Review Report For: Case Report: retained gutta-percha as a cause for persistent maxillary sinusitis and pain [version 2; peer review: 3 approved] . F1000Research 2014, 3 :81 ( https://doi.org/10.5256/f1000research.4060.r4316) NOTE: it is important to ensure the information in square brackets after the title is included in this citation. The direct URL for this report is: https://f1000research.com/articles/3-81/v1#referee-response-4316 Alongside their report, reviewers assign a status to the article: Approved - the paper is scientifically sound in its current form and only minor, if any, improvements are suggested Approved with reservations - A number of small changes, sometimes more significant revisions are required to address specific details and improve the papers academic merit. 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