Rubella Virus-Associated Cutaneous Granulomas in an Adult With TAP1 Deficiency Case Report

Abstract Rubella virus-associated granulomas commonly occur in immunocompromised individuals, exhibiting a diverse range of clinical presentations. These manifestations can vary from predominantly superficial cutaneous plaques or nonulcerative nodules to more severe deep ulcerative lesions, often accompanied by extensive necrosis and significant tissue destruction. TAP1 deficiency, an exceedingly rare primary immunodeficiency disorder, presents with severe chronic sino-pulmonary infection and cutaneous granulomas. This report constitutes the inaugural documentation of rubella virus-associated cutaneous granulomas in a patient with TAP1 deficiency. This novel observation holds potential significance for the field of diagnosis and investigative efforts in the context of immunodeficiency disorders.