Estrogen Receptor,Activator Protein 1 and Endometriosis

Endometriosis is an estrogen-dependent disorder and its biological behavior derives from the exposure to estrogen.The biological effects of estrogen are mainly mediated through estrogen receptor.Activator protein 1 is an important nuclear transcription regulator,involved in cell proliferation,differentiation and apoptosis.This paper reviewed the subtypes of estrogen receptors,the structure,function of activator protein 1 and their expression in orthotopic and ectopic endometria,in aiming to study their role in the onset and progress of endometriosis.