A METHOD OF TREATING BENIGN GYNAECOLOGICAL DISORDERS AND A DRUG DELIVERY VEHICLE FOR USE IN SUCH A METHOD

One aspect of the present invention is concerned with a method of treating a benign gynaecological disorder in a female mammal using a drug delivery vehicle, said benign gynaecological disorders being selected from the group consisting of uterine leiomyomas, endometriosis, adenomyosis, functional menorrhagia and metrorrhagia, the method comprising intravaginal administration of the drug delivery vehicle to the female mammal suffering from the benign gynaecological disorder, said drug delivery vehicle containing a selective estrogen enzyme modulator (SEEM), wherein the method provides the SEEM in a therapeutically effective dosage to prevent or reduce symptoms of said benign gynaecological disorder, said SEEM being selected from the group consisting of aromatase inhibitors, cyclo-oxygenase 2 (COX-2) inhibitors, 17 ß-hydroxysteroid dehydrogenase type 1 inhibitors and combinations thereof. The present method is suitable for long term medical therapy of estrogen sensitive benign gynaecological disorders, particularly for pre- and peri-menopausal females and does not cause serious side-effects. Another aspect of the invention is concerned with a drug delivery vehicle for intravaginal use, comprising at least 10 mug of a SEEM selected from the group consisting of aromatase inhibitors, 17ß-hydroxysteroid dehydrogenase type 1 inhibitors and combinations thereof; and pharmaceutically acceptable excipient.