Inhibitory effect of TMP on microvessel density in rat endometriosis

Objective:To observe the effect of TMP on micro-vessel density(MVD) and antiangiogenesis in rat endometriosis.Methods:Wistar rat endometriosis models were established,after 4 weeks,the successful endometriosis rats were divided into control group,TMP50mg·kg-1·d-1group,TMP100mg·kg-1·d-1group and TMP200 mg·kg-1·d-1group and the rats were given successive intragastric administration for 15 days.Ectopic endometrium graft volume was observed and MVD was determined by immunostaining for CD34.Results:MVD in endometriosis was decreased remarkably after 4-week treatment with TMP(P0.05),with was no significant difference.TMP could significantly inhibit proliferation of ectopic endometrium in a dose-dependent manner.Conclusion:TMP has an inhibitory effect on the MVD expression and angiogenesis in rat endometriosis in a dose-dependent manner.TMP may become a new drug of antiangiogenesis in endometriosis.