Systemic sclerosis complicating endometrial adenocarcinoma: A case report

Hui‐Chang Yan, Cui Huang
In: Medicine · 2025 · vol. 104(20) , pp. e42553 · doi:10.1097/md.0000000000042553 · PMID:40388753 · W4410548674
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This case report describes a 55-year-old female diagnosed with systemic sclerosis and endometrial adenocarcinoma, exploring potential shared pathophysiological mechanisms.

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Abstract

RATIONALE: Systemic sclerosis (SSc) is a rare systemic autoimmune disease, and it is even more uncommon to encounter it alongside a neoplasm. PATIENT CONCERNS: A 55-year-old female patient presented to our clinic with a 7-year history of cyanosis affecting multiple fingers bilaterally, accompanied by Raynaud's phenomenon, mild pain, numbness, and morning stiffness. One and a half years ago, she was diagnosed with endometrial adenocarcinoma (Federation International of Gynecology and Obstetrics stage IIIa) for frequent abdominal pain and abnormal vaginal bleeding. DIAGNOSES: Following a comprehensive physical examination and laboratory tests, she was diagnosed with SSc according to the 2013 American College of Rheumatology/European League Against Rheumatism classification criteria. INTERVENTIONS: Although we discussed potential treatment options and prognosis with her, she ultimately declined therapy. OUTCOMES: She was lost to follow-up. LESSONS: A shared pathophysiological process may underlie the development of both SSc and malignancy, possibly driven by persistent chronic inflammation and immune dysregulation.

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