RETRACTED: METTL3-mediated m6A modification of circNOTCH2 attenuates osteogenic impairment of PDLSCs in inflammatory microenvironment via the miR-193b-3p/KCNJ2/NLRP3 axis

RETRACTED: METTL3-mediated m6A modification of circNOTCH2 attenuates osteogenic impairment of PDLSCs in inflammatory microenvironment via the miR-193b-3p/KCNJ2/NLRP3 axis | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF RETRACTED: METTL3-mediated m6A modification of circNOTCH2 attenuates osteogenic impairment of PDLSCs in inflammatory microenvironment via the miR-193b-3p/KCNJ2/NLRP3 axis Xiliang Yang, Rong Li, Nan Wang, Yifan Cai, Huijie Liu, Jiaolong Wang, and 1 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-7971329/v1 This work is licensed under a CC BY 4.0 License Status: Under Review Version 1 posted You are reading this latest preprint version Editorial Note The authors have requested that this preprint be removed from Research Square due to a pending patent application. Editorial notes are used to provide important context regarding the topic of a preprint or to alert readers to potential issues concerning that preprint or a downstream publication associated with it. For more information on editorial notes, see our Editorial Policies . Abstract The authors have requested that this preprint be removed from Research Square due to a pending patent application. Cite Share Download PDF Status: Under Review Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-7971329","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"","associatedPublications":[],"authors":[{"id":570398685,"identity":"e69f15b8-26bf-4458-a5f8-7224da4bdc5e","order_by":0,"name":"Xiliang Yang","email":"","orcid":"","institution":"Nanchang University","correspondingAuthor":false,"prefix":"","firstName":"Xiliang","middleName":"","lastName":"Yang","suffix":""},{"id":570398686,"identity":"895922ac-4e77-40fe-b3c2-16830aac6f06","order_by":1,"name":"Rong Li","email":"","orcid":"","institution":"Nanchang University","correspondingAuthor":false,"prefix":"","firstName":"Rong","middleName":"","lastName":"Li","suffix":""},{"id":570398687,"identity":"105103a4-a422-4113-a7a6-06d5476c7178","order_by":2,"name":"Nan Wang","email":"","orcid":"","institution":"Nanchang University","correspondingAuthor":false,"prefix":"","firstName":"Nan","middleName":"","lastName":"Wang","suffix":""},{"id":570398688,"identity":"ec47cd0b-cdcc-421c-97c3-0b77d6e27cb7","order_by":3,"name":"Yifan Cai","email":"","orcid":"","institution":"Nanchang University","correspondingAuthor":false,"prefix":"","firstName":"Yifan","middleName":"","lastName":"Cai","suffix":""},{"id":570398689,"identity":"103797d3-0a7b-4416-982b-311f34cd1e5d","order_by":4,"name":"Huijie Liu","email":"","orcid":"","institution":"Nanchang University","correspondingAuthor":false,"prefix":"","firstName":"Huijie","middleName":"","lastName":"Liu","suffix":""},{"id":570398690,"identity":"269f55c2-81c3-4023-894f-caf37d78a662","order_by":5,"name":"Jiaolong Wang","email":"","orcid":"","institution":"Nanchang University","correspondingAuthor":false,"prefix":"","firstName":"Jiaolong","middleName":"","lastName":"Wang","suffix":""},{"id":570398691,"identity":"d02ed730-b3e3-47c4-8ab5-ed24616819eb","order_by":6,"name":"Lan Liao","email":"data:image/png;base64,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","orcid":"","institution":"Nanchang University","correspondingAuthor":true,"prefix":"","firstName":"Lan","middleName":"","lastName":"Liao","suffix":""}],"badges":[],"createdAt":"2025-10-28 17:11:44","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-7971329/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-7971329/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"\u003cp\u003eThe authors have requested that this preprint be removed from Research Square due to a pending patent application.\u003c/p\u003e","failedWorkflow":false,"files":[],"financialInterests":"","formattedTitle":"RETRACTED: METTL3-mediated m6A modification of circNOTCH2 attenuates osteogenic impairment of PDLSCs in inflammatory microenvironment via the miR-193b-3p/KCNJ2/NLRP3 axis","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":true,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":false,"isWithdrawnOrRetracted":true,"journal":{"display":true,"email":"[email protected]","identity":"stem-cell-research-and-therapy","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scrt","sideBox":"Learn more about [Stem Cell Research \u0026 Therapy](http://stemcellres.biomedcentral.com)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/scrt/default.aspx","title":"Stem Cell Research \u0026 Therapy","twitterHandle":"@BioMedCentral","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"","lastPublishedDoi":"10.21203/rs.3.rs-7971329/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-7971329/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eThe authors have requested that this preprint be removed from Research Square due to a pending patent application.\u003c/p\u003e","manuscriptTitle":"RETRACTED: METTL3-mediated m6A modification of circNOTCH2 attenuates osteogenic impairment of PDLSCs in inflammatory microenvironment via the miR-193b-3p/KCNJ2/NLRP3 axis","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2025-12-17 17:08:28","doi":"10.21203/rs.3.rs-7971329/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"stem-cell-research-and-therapy","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"scrt","sideBox":"Learn more about [Stem Cell Research \u0026 Therapy](http://stemcellres.biomedcentral.com)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/scrt/default.aspx","title":"Stem Cell Research \u0026 Therapy","twitterHandle":"@BioMedCentral","acdcEnabled":true,"dfaEnabled":true,"editorialSystem":"em","reportingPortfolio":"BMC/SO AJ","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"9a3e6939-21d7-4e96-b208-b91fa22fd01c","owner":[],"postedDate":"December 17th, 2025","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"under-review","subjectAreas":[],"tags":[],"updatedAt":"2026-04-30T09:40:32+00:00","versionOfRecord":[],"versionCreatedAt":"2025-12-17 17:08:28","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-7971329","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-7971329","identity":"rs-7971329","version":["v1"]},"buildId":"8U1c8b4HqxoKbykW_rLl7","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}