Polymorphisms of TGF-β1 and TGF-β3 in Chinese women with Gestational Diabetes Mellitus

Polymorphisms of TGF-β1 and TGF-β3 in Chinese women with Gestational Diabetes Mellitus | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research article Polymorphisms of TGF-β1 and TGF-β3 in Chinese women with Gestational Diabetes Mellitus Yinglei Xu, Chunlian Wei, Cuijiao Wu, Mengmeng Han, Jingli Wang, and 4 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-62203/v3 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 07 Dec, 2020 Read the published version in BMC Pregnancy and Childbirth → Version 3 posted 2 You are reading this latest preprint version Show more versions Abstract Background: Gestational diabetes mellitus (GDM) is a pregnancy-specific carbohydrate intolerance Which can cause a large number of perinatal and postpartum complications. The members of Transforming growth factor-β (TGF-β) superfamily play key roles in the homeostasis of pancreatic β-cell and may involve in the development of GDM. This study aimed to explore the association between the polymorphisms of TGF-β1 , TGF-β3 and the risk to GDM in Chinese women. Methods: This study included 919 GDM patients (464 with preeclampsia and 455 without preeclampsia) and 1177 healthy pregnant women. TaqMan allelic discrimination real-Time PCR was used to genotype the TGF-β1 (rs4803455) and TGF-β3 (rs2284792 and rs3917201), The Hardy-Weinberg equilibrium (HWE) was evaluated by chi-square test. Results: An increased frequency of TGF-β3 rs2284792 AA and AG genotype carriers was founded in GDM patients (AA vs. AG+GG: χ²=6.314, P =0.012, OR=1.270, 95%CI 1.054-1.530; AG vs. GG+AA: χ²=8.545, P =0.003, OR=0.773, 95%CI 0.650-0.919). But there were no significant differences in the distribution of TGF-β1 rs4803455 and TGF-β3 rs3917201 between GDM and healthy women. In addition, no significant differences were found in allele and genotype frequencies among GDM patients with preeclampsia (PE). Conclusions: The AA and AG genotype of TGF-β3 rs2284792 polymorphism may be significantly associated with increased risk of GDM in Chinese population. Maternal & Fetal Medicine polymorphism GDM PE TGF-β1 TGF-β3 Background GDM is the most common maternal metabolic disturbance that is defined as glucose intolerance of variable severity with onset or first detection during pregnancy[1, 2]. The prevalence of GDM varies from 1%-22% of all pregnancies depending on different populations and diagnostic criteria[3-5]. GDM not only increases the risk of maternal and fetal perinatal complications, but also has long-term adverse consequences for offspring [6, 7]. The most familiar complication following GDM is PE which shares common clinical risk factors with GDM such as obesity, advanced maternal age and diabetes[8]. GDM is characterized by increased insulin resistance and defective insulin secretion which is due to the inability of pancreatic β cells[2]. However, the etiology is complex due to disordered metabolism and intrauterine environment during pregnancy. Extensive efforts have been made to explore the pathogenesis and to find new targets for prediction of GDM[2, 9, 10]. The TGF-β superfamily, including TGF-β isoforms, activins, inhibins and bone morphogenetic proteins（BMPs), is involved in a myriad of biological processes such as cell proliferation, differentiation and death[11]. In addition, TGF-β signaling has been indicated to play key roles in the development of GDM and GDM risk factors. BMPs disfunction will impair insulin signal and glucose homeostasis in the setting of diabetes[12]. Activins can promote the proliferation of pancreatic β-cell and secretion of insulin[13]. TGF-β isoforms are known to stimulate adipocyte proliferation, insulin resistance and subclinical inflammation[14]. In recent years, the role of genetic factors in the pathogenesis of GDM has been increasingly investigated. The major genetic studies of GDM are candidate gene studies, which have revealed that some single nucleotide polymorphisms (SNPs) in cytokine genes are associated with susceptibility to GDM [15, 16]. SNPs within the coding and signal sequences can affect gene transcriptional activity, and then change the production of proteins[17]. Several studies have reported that altered cytokines expression are related to the severity and progression of the GDM[18, 19]. Therefore, the cytokine genes with positive SNP loci may be a pregnancy biomarker for screening GDM. TGF-β1 and TGF-β3 belong to TGF-β isoforms and have differential expression in the human endometrium and placenta[11]. Both of them contribute to normal homeostasis of pancreas and insulin action[20]. The enhanced expression of TGF-β1 induced by hyperglycemia was detected in individuals with GDM[21, 22]. Although there is no direct relation between TGF-β3 and GDM, TGF-β3 participates in many GDM complications such as PE and pregnancy-induced hypertension[23]. Three tag SNPs (rs4803455, rs2284792, and rs3917201), located in introns of TGF-β1 and TGF-β3 locus respectively, can affect the transcriptional activity and change the expression of proteins[24-26]. Therefore, we supposed that these three SNPs might be target SNPs, and try to investigate the relationship between polymorphisms of TGF-β1 , TGF-β3 and the risk of GDM. Methods Subjects This study was conducted based on 919 pregnant women with GDM and 1177 healthy pregnant women with normal glucose tolerance, recruited from the clinical pregnancy registries at the Affiliated Hospital of Qingdao University, People’s Hospital of Liaocheng City and People's Hospital of Linyi City. Informed consent was issued and signed by all subjects and all investigations were approved by the ethics committee of the Affiliated Hospital of Qingdao University. All the participants underwent a 75 g oral glucose tolerance test (OGTT) at 24–28 weeks' gestation. The diagnosis of GDM was based on the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria when one of the following plasma glucose values in the OGTT was met or exceeded, fasting plasma glucose 92 mg/dl (5.1 mmol/l), 1h plasma glucose 180 mg/dl (10.0 mmol/l) and 2h plasma glucose 153 mg/dl (8.5 mmol/l). Plasma glucose during OGTT of the follow-up study was measured by enzymatic hexokinase photometric assay. Exclusion criteria included heart diseases, chronic hypertension, diabetes mellitus, thyroid diseases, kidney disorders, abnormal liver function, twin or multiple pregnancies, as well as in-vitro fertilization in the present gestation. Women were recruited in the study group when first diagnosed as GDM at 24-28 weeks’ gestation. Then, they were taken blood for testing before diet control and insulin therapy. Besides, 919 GDM patients were categorized into 455 without PE and 464 with PE which was determined on the base of the questionnaire, clinical features, and data. A newly onset of hypertension (≥140/90 mmHg) with proteinuria C of 300mg or higher in 24-hour after 20 weeks of gestation was diagnosed as PE. Methods Genomic DNA was extracted from peripheral venous blood by alkaline lysis method and collected by centrifugal column in the Qiagen blood DNA extraction kit (Qiagen, Hilden, Germany). TaqMan allelic discrimination real-time PCR (Life Technologies, Grand Island, NY, USA) was used to genotype the polymorphisms of rs4803455 in TGF-β1 , rs2284792 and rs3917201 in TGF-β3 . The TaqMan probes and primers were designed by Applied Bio-systems or Life Technologies (New York. USA). TGF-β1 and TGF-β3 were amplified using the following primers: 5’-GCTGCAAACATTCTGGGGTTT-3’ for TGF-β1 rs4803455, 5’-GGGTGGGACCAGGGAATCT-3’ for TGF-β3 rs2284792 and 5’-CGCCTCAAGAAGCAGAAGGAT-3’ for TGF-β3 rs3917201. Reaction volume was 25μl: 1.25μL 20 × SNP Genotyping Assay, 12.5μL 2 × PCR Master Mix, and 11.25μL DNA and DNase-free water. 1000™ Thermal cycler and CFX96™ Real-time system (Bio-Rad, California, USA) were carried out to amplifications as following conditions: 95°C for 3 min, followed by 45 cycles at 95°C for 15 s and 60°C for 1 min. The fluorescent signals from VIC/FAM-labeled probes were detected for each cycle. Discrimination of genotypes was conducted with BioRad CFX manager 3.0 software. Statistical analysis Statistical software package IBM SPSS 22.0 (SPSS Inc., Chicago, IL, USA) was used to manipulate all data. Student’s t -test was utilized to compare the demographic and clinical characteristics of cases and controls. An analysis of variance (ANOVA) was used to conduct the genotype-phenotype analysis. A chi-square test was performed to assess the HWE in the controls. Allelic and genotypic distributions were enrolled in the comparison by using Pearson’s χ² test which was substituted with Fisher’s exact test when expected values were below 5. P < 0.05 (two-sided) was considered to represent statistically significance. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to reveal the relative risk degree. A P -value < 0.05 (two-sided) was taken as statistical significance for all statistical analyses. Results Demographic and clinical characteristics of GDM and controls Subjects were categorized into 919 GDM patients and 1177 controls. Demographic and clinical data of different groups were summarized in the supplemental table. Both groups had similar age distribution, times of gravidity, and number of abortions. The mean age of cases and controls was 30.71±4.18 and 30.75±4.21 years old. However, in GDM group, weeks of admission and delivery intended to be earlier (P<0.001) and the weight gain of newborns was heavier than in the control group as expected (P<0.001). TGF-β1 and TGF-β3 polymorphism analysis The subjects of the control group enrolled in this study were in accordance with HWE for these SNPs and displayed a group representative at the significance level of P＞0.05. The distributions of the genotypes and alleles in GDM cases and controls were reported in Table 1. We observed a statistically significant difference between GDM and healthy women in the frequencies of TGF-β3 rs2284792 (χ² =9.064, P =0.011). However, no statistical differences were detected either in TGF-β1 rs4803455 or in TGF-β3 rs3917201 between two groups in terms of genotypic frequencies. As shown in Table 1, the allelic frequencies of rs2284792 between two groups were not obviously different (χ² =1.592, P =0.207, OR=1.082, 95%CI 0.957-1.224). When categorized into three models (AA vs AG+GG, GG vs AG+AA and AG vs GG+AA), there was a significant difference between these two groups (For AA vs AG+GG model, χ²=6.314, P=0.012, OR 1.270, 95%CI 1.054-1.530; For AG vs GG+AA model, χ²=8.545, P=0.003, OR=0.773, 95%CI 0.650-0.919). Consistently, allelic frequencies of TGF-β1 rs4803455 or TGF-β3 rs3917201 were statistically insignificant. TGF-β1 and TGF-β3 polymorphism analysis between GDM patients with and without PE To further study the association between variants of the three SNPs and complications, samples were categorized into GDM cases with and without PE. The distributions of the genotypes and alleles in GDM patients with and without PE are shown in Table 2 and Table 3. In GDM cases without PE group, the statistical difference between cases and controls in genotypic distributions of TGF-β3 rs2284792 was observed (χ²=9.774, P =0.008). Also, the same was found for allelic frequencies in AA vs AG+GG (χ²=8.476, P =0.004 OR=1.427, 95%CI 1.122-1.813) and AG vs GG+AA (χ²=7.842, P =0.005 OR=0.734, 95%CI 0.590-0.912). In contrast to TGF-β3 rs2284792, no obvious difference was found in either the genotypic distributions or allelic frequencies of TGF-β1 rs4803455 and TGF-β3 rs3917201 among GDM only cases. In GDM cases with PE group, however, no obvious difference was found in either the genotypic distributions or allelic frequencies of three SNPs (for rs4803455, χ²=1.266, P =0.531 by genotype, χ 2 =0.069, P =0.793, OR =1.021, 95%CI 0.873-1.194 by allele; when for rs2284792, χ 2 =3.619, P =0.164 by genotype, χ 2 =0.021, P =0.885, OR =1.011, 95%CI 0.867-1.1791by allele; and for rs3917201, χ 2 =0.359, P =0.836 by genotype, χ 2 =0.015, P =0.903, OR =1.009, 95%CI 0.867-1.175 by allele). Analysis of Genotype-Phenotype Relationship Analysis of the relationship between the genotypes of TGF-β3 rs2284792 and demographic characteristics among total GDM patients was shown in Table 4. However, no statistical differences were found for the genotype-phenotype relationship of rs2284792. Discussion In this study, the associations between TGF-β1 , TGF-β3 polymorphisms and GDM were examined in a Chinese population. Among women with GDM, we firstly found an effective association between the tag SNP TGF-β3 rs2284792 and GDM risk. Besides, we confirmed that the A allele and the AA and AG genotypes were susceptible, while the G allele/GG genotype may be protective factors. However, there were no statistically significant differences in the distribution of TGF-β1 rs4803455 and TGF-β3 rs3917201 genotypes between GDM and healthy women. Previous genetic study of GDM is to find candidate genes that was based on biological plausibility[27]. Recently, genome-wide association analysis studies were performed to identify some susceptibility genes associated with GDM[4]. The genetic variants of candidate genes have been revealed to contribute to the risk of GDM. For example, rs12255372 variant in Transcription factor 7-like 2 was indicated to interact with adiposity to alter β-cell function in 132 Mexican-American families with GDM[28]. The homozygosity for G972R polymorphism in Insulin receptor substrate-1 might indicate an increased risk for GDM in Saudi women[29]. There was also was significantly associated with genotypes and alleles of the CC chemokine ligand 2 rs1024611 and rs4586 polymorphisms[18] and GDM. Interestingly, many GDM associated candidate genes can express cytokines implicated in the inflammatory conditions during pregnancy[30]. GDM is characterized by varying degrees of hyperglycemia due to the inability of pancreatic β-cells to adequately respond to the increased insulin requirements during the second and third trimester[31, 32]. The etiology of GDM may be explained by many factors including cytokines, hormones, lifestyle as well as genetic disposition[33]. TGF-β isoforms are multifunctional factors that regulate embryonic development, immunity, and epithelial homeostasis[34]. Genetic polymorphisms of TGF-β isoforms were linked with an increased likelihood of having GDM and complications such as PE and diabetic nephropathy[15, 35]. With such attributes, we chose TGF-β1 and TGF-β3 as target genes to uncover the genetic disposition of GDM. TGF-β1 is reported to be a key cytokine in insulin resistance and obesity. Over-expression of TGF-β1 can lead to decreased β-cell mass and insulin secretion[36]. TGF-β1 rs4803455 polymorphism is an A/C single-nucleotide variation on chromosome 19q13.2 and can alter the expression of insulin receptor substrate 2 associated with insulin resistant in GDM, but not depending on its expression in the pathway[37]. Moreover, a previous study suggested that TGF-β1 rs4803455 showed the effectiveness to capture the associations with cancer risk[38]. However, our data revealed that TGF-β1 rs4803455 was not a significant risk factor of GDM in the Chinese Population. The difference between these studies could be attributed to the discordance of population genetic background. However, the finite sample size in these studies is another limiting factor to have a coincident conclusion. This is the first study to show the relationship between the genetic polymorphism of TGF-β3 gene and GDM. Candidate SNPs previously described were chosen based on their location within the gene, and a tag SNP (rs2284792: A>G) selected with SNP picker using data from the Caucasian population was located within the introns of TGF-β3 [39]. Our studies revealed an effective association between the tag SNP rs2284792 and GDM risk. Besides, we confirmed that the A allele and the A allele-containing genotypes (AA and AG) were susceptible, while the G allele/GG genotype may be protective factors. TGF-βs in mammals exhibit many overlapping biological activities and appear interchangeable. TGF-β3 knock-in ameliorate inflammation due to TGF-β1 deficiency while promoting glucose tolerance[40]. Reduced TGF-β3 expression can cause hypertrophy and induce glucose intolerance[41]. Therefore, altered generation made by polymorphic variants in TGF-β3 may affect glucose homeostasis, thus leading to GDM. GDM is a transient presentation of long-standing metabolic malfunction and may be expected to have an association with PE[42]. The pathophysiology of PE is characterized by endothelial dysfunction which may be induced by down-regulation of TGF-β signaling. TGF-β isoforms were predisposed to have obvious susceptible associations with PE and were supposed as a biomarker for assessment of PE severity[43, 44]. TGF- 𝛽 1 codon 10T/C was observed to have a higher frequency of T＞C allele in Type 2 Diabetes Mellitus patients with hypertension[45]. A fetal TGF-β3 variant (rs11466414) is associated with PE in a predominantly Hispanic population[44]. In consideration of comparable clinical characteristics, we hypothesized that the variants of TGF-β isoforms may relate to the development of both disease conditions. Then, we analyzed TGF-β1 (rs4803455) and TGF-β3 (rs2284792 and rs3917201) polymorphisms among GDM cases with PE. However, no obvious difference was found in either the genotypic distributions or allelic frequencies among above three SNPs. The complexity of several pathogenic pathways including metabolic, immune, and endothelial dysfunction can account for the invalid assumption. Insulin resistance which is highly prevalent in patients with GDM can only partially explain the development of PE[42]. To sum up, TGF-β3 rs2284792 may be the independent effective genetic locus for GDM alone. Conclusions This study indicated that the AA and AG genotype rs2284792 polymorphism of TGF-β3 was associated with the increased risk of GDM. However, some evident shortcomings are the limited sample size and the different ethnic origins. Furthermore, some environmental factors, such as behavioral and pharmacological interventions, will be considered in our future studies. All these studies highlight the need of long-term cohort studies of women with GDM for ultimately improving pregnancy outcomes. Declarations Ethics approval and consent to participate Informed consent was issued and signed by all subjects and all investigations were approved by the ethics committee of the Affiliated Hospital of Qingdao University. Consent for publication Not applicable. Availability of data and materials The original data used to support the findings of this study are available from the corresponding author upon request. Competing interests The authors declare that they have no competing interests. Funding This work was supported by Natural Science Fund Project of Shandong Province [ZR2019MH127]; Key research and development plan of Shandong Province [ 2019GSF108106] and the Application and Basic Research Project of Qingdao[18-2-2-27-jch]. The funding body did not play a role in the design of the study or in the collection, analysis, and interpretation of data or in writing the manuscript. Authors’ contributions YLX: study design, protocol development; CJW, MMH, JLW and HBH: collecting clinical samples; YLX and CLW: data analysis; YLX: writing the manuscript; LZ, YC and SGL: critical review of the manuscript; YC and SGL is responsible for the integrity and the accuracy of the data analysis. All authors have read and approved the final version of the manuscript. Acknowledgments Not applicable. Additional file Additional file 1: supplemental table. The demographic and clinical characteristics of GDM and controls Author details 1 Department of Medical Genetic, the Affiliated Hospital of Qingdao University, 266000, Qingdao, China. 2 Prenatal Diagnosis Center, the Affiliated Hospital of Qingdao University, 266000, Qingdao, China. 3 Department of Immunology, School of Basic Medical Sciences, Capital Medical University, 100000, Beijing, China. 4 Department of Histology and Embryology, Qingdao University Medical College, 260000, Qingdao, China. 5 Department of Clinical laboratory, the Affiliated Hospital of Qingdao University, Qingdao, China. 6 Department of Endocrinology and Metabolism, the Affiliated Hospital of Qingdao University, 266000, Qingdao, China. Abbreviations TGF-β: Transforming growth factor-β; GDM: Gestational diabetes mellitus; HWE: Hardy-Weinberg equilibrium; PE: preeclampsia; SNPs: Signal Nucleotide Polymorphisms; OGTT: oral glucose tolerance test; ORs: Odds ratios; Cis: confidence intervals References Lowe, W.L., Jr., D.M. Scholtens, V. Sandler,M.G. Hayes.Genetics of Gestational Diabetes Mellitus and Maternal Metabolism.Curr Diab Rep.2016; 16 (2):15. Johns, E.C., F.C. Denison, J.E. Norman,R.M. Reynolds.Gestational Diabetes Mellitus: Mechanisms, Treatment, and Complications.Trends Endocrinol Metab.2018; 29 (11):743-754. Chiefari, E., B. Arcidiacono, D. Foti,A. Brunetti.Gestational diabetes mellitus: an updated overview.J Endocrinol Invest.2017. Zhang, C., W. Bao, Y. Rong, H. Yang, K. Bowers, E. Yeung,M. Kiely.Genetic variants and the risk of gestational diabetes mellitus: a systematic review.Hum Reprod Update.2013; 19 (4):376-90. Enninga, E.A.L., A.M. Egan, L. Alrahmani, A.A. Leontovich, R. Ruano,M.P. 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Carpenter, M.W.Gestational diabetes, pregnancy hypertension, and late vascular disease.Diabetes Care.2007; 30 Suppl 2 :S246-50. Lim, J.H., S.Y. Kim, S.Y. Park, M.H. Lee, J.H. Yang, M.Y. Kim, J.H. Chung, S.W. Lee,H.M. Ryu.Soluble endoglin and transforming growth factor-beta1 in women who subsequently developed preeclampsia.Prenat Diagn.2009; 29 (5):471-6. Wilson, M.L., D.H. Desmond, T.M. Goodwin, D.A. Miller,S.A. Ingles.Maternal and fetal variants in the TGF-beta3 gene and risk of pregnancy-induced hypertension in a predominantly Latino population.Am J Obstet Gynecol.2009; 201 (3):295 e1-5. Ramirez, A., M. Hernandez, R. Suarez-Sanchez, C. Ortega, J. Peralta, J. Gomez, A. Valladares, M. Cruz, M.A. Vazquez-Moreno,F. Suarez-Sanchez.Type 2 diabetes-associated polymorphisms correlate with SIRT1 and TGF-beta1 gene expression.Ann Hum Genet.2020; 84 (2):185-194. Tables Table 1 The comparison of genotypic and allelic frequencies of all SNPs between GDM (all cases) and controls Cases Controls χ2 p-value OR 95%CI rs4803455 Genotypes AA 142 173 1.206 0.574 AC 412 556 CC 365 448 Alleles A 696 902 0.089 0.766 1.019 0.899-1.156 C 1142 1452 rs2284792 Genotypes AA 268 404 9.064 0.011* AG 487 548 GG 164 225 AA 268 404 AG+GG 651 773 6.314 0.012* 1.270 1.054-1.530 GG 164 225 AG+AA 755 952 0.511 0.458 1.088 0.871-1.360 AG 487 548 GG+AA 432 629 8.545 0.003* 0.773 0.650-0.919 Alleles A 1023 1356 1.592 0.207 1.082 0.957-1.224 G 815 998 rs3917201 Genotypes GG 220 294 0.303 0.895 AG 468 592 AA 231 291 Alleles A 908 1180 0.218 0.641 1.029 0.911-1.163 G 930 1174 *p < 0.05 is considered statistically significant, OR ODDs ratio, CI Confidence interval Table 2 The comparison of genotypic and allelic frequencies of all SNPs between GDM without PE and controls Cases Controls χ2 p-value OR 95%CI rs4803455 Genotypes AA 70 173 0.631 0.730 AC 205 556 CC 180 448 Alleles A 345 902 0.046 0.831 1.017 0.869-1.191 C 565 1452 rs2284792 Genotypes AA 122 404 9.774 0.008* AG 247 548 GG 86 225 AA 122 404 AG+GG 333 773 8.476 0.004* 1.472 1.122-1.813 GG 86 225 AG+AA 369 952 0.010 0.921 1.014 0.769-1.336 AG 247 548 GG+AA 208 629 7.842 0.005* 0.734 0.590-0.912 Alleles A 491 1356 3.555 0.059 1.159 0.994-1.352 G 419 998 rs3917201 Genotypes GG 108 294 0.571 0.752 AG 227 592 AA 120 291 Alleles A 443 1180 0.549 0.459 1.060 0.909-1.235 G 467 1174 *p < 0.05 is considered statistically significant, OR ODDs ratio, CI Confidence interval Table 3 The comparison of genotypic and allelic frequencies of all SNPs between GDM with PE and controls Cases Controls χ2 p-value OR 95%CI rs4803455 Genotypes AA 72 173 1.266 0.531 AC 207 556 CC 185 448 Alleles A 351 902 C 577 1452 rs2284792 Genotypes AA 146 404 3.619 0.164 AG 240 548 GG 78 225 Alleles A 532 1356 0.021 0.885 1.011 0.867-1.179 G 396 998 rs3917201 Genotypes GG 112 294 0.359 0.836 AG 241 592 AA 111 291 Alleles A 463 1180 0.015 0.903 1.009 0.867-1.175 G 465 1174 *p < 0.05 is considered statistically significant, OR ODDs ratio, CI Confidence interval Table 4 Associations between genotypes of rs2284792 and characteristics among total GDM patients. Rs2284792(A/G) AA AG GG AA vs. AG AA vs GG AG vs GG AA vs AG+GG GG vs AG+AA AG vs GG+AA (n) (n) (n) P a p b p c p d p e p f cases 268 487 164 Demographic characteristics (Mean ± S) Fasting blood glucose (mmol/l) 5.90±2.13 5.75±2.22 5.76±2.33 0.087 0.097 0.960 0.059 0.407 0.360 Systolic blood pressure (mmHg) 137.65±22.24 137.41±24.86 137.53±22.06 0.166 0.425 0.468 0.224 0.997 0.231 Diastolic blood pressure (mmHg) 77.09±12.36 77.17±11.86 77.01 0.519 0.560 0.137 0.972 0.186 0.177 WBC (×109/L) 10.51±2.99 10.62±3.05 10.62±3.05 0.122 0.144 0.921 0.099 0.514 0.436 RBC (×1012/L) 4.41±1.73 4.37±1.17 4.51±1.91 0.588 0.233 0.234 0.997 0.085 0.185 Hb (g/L) 116.43±17.40 116.47±14.12 116.32±14.31 0.823 0.451 0.308 0.753 0.343 0.560 neutrophil (×109/L) 8.40±2.54 8.24±2.43 8.44±2.81 0.157 0.779 0.068 0.557 0.167 0.056 PLT (×109/L) 227.30±58.26 226.72±67.55 226.69±58.86 0.102 0.149 0.953 0.079 0.562 0.252 PT (s) 10.64±1.59 10.68±1.60 10.71±1.83 0.436 0.283 0.572 0.330 0.402 0.808 APTT (s) 30.57±3.93 30.52±3.91 30.63±3.38 0.441 0.446 0.134 0.720 0.192 0.300 ALT (IU/L) 27.66±21.05 26.95±16.47 27.14±19.28 0.065 0.356 0.663 0.075 0.920 0.132 AST (IU/L) 29.82±18.52 29.53±16.51 29.57±19.35 0.384 0.599 0.930 0.389 0.871 0.510 Creatinine (umol/L) 58.58±18.75 58.49±19.15 58.49±17.09 0.716 0.788 0.986 0.704 0.931 0.782 Body mass before pregnancy (kg) Body mass increase during pregnancy (kg) BMI before pregnancy (kg/m 2 ) BMI at birth (kg/m 2 ) 59.73±3.43 17.53±1.25 23.97±0.79 30.7±0.92 63.58±0.95 17.57±0.62 24.30±0.34 30.91±0.42 63.04±0.74 16.24±0.47 24.23±0.40 30.43±0.46 0.146 0.978 0.698 0.841 0.159 0.318 0.804 0.827 0.647 0.086 0.896 0.456 0.116 0.614 0.754 0.964 0.959 0.072 0.974 0.463 0.422 0.123 0.837 0.472 Pa value between AA and AG; Pb value between AA and GG; Pc value between AG and GG; Pd value between AA and AG+GG ; Pe value between GG and AG+AA; Pf value between AG and GG+AA. p < 0.05 is considered statistically significant. WBC, White Blood Cell; RBC, Red Blood Cell; Hb, Hemoglobin; PLT, Platelet; PT,prothrombin time; APTT, activated partial thromboplastin time; ALT, glutamic pyruvic transaminase; AST, glutamic oxaloacetictransaminase. Supplementary Files supplementaltable.docx Additional file 1: supplemental table. The demographic and clinical characteristics of GDM and controls Cite Share Download PDF Status: Published Journal Publication published 07 Dec, 2020 Read the published version in BMC Pregnancy and Childbirth → Version 3 posted Submission checks completed at journal 28 Nov, 2020 Editorial decision: Accept 24 Nov, 2020 You are reading this latest preprint version Show more versions Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-62203","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Research article","associatedPublications":[],"authors":[{"id":5489575,"identity":"23f483de-2b6e-41b0-a93a-d0a6ce90eb0d","order_by":0,"name":"Yinglei Xu","email":"","orcid":"https://orcid.org/0000-0002-7777-2709","institution":"the Affiliated Hospital of Qingdao University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Yinglei","middleName":"","lastName":"Xu","suffix":""},{"id":5489576,"identity":"8b057944-92af-448c-98a2-7a377fa4c5b6","order_by":1,"name":"Chunlian Wei","email":"","orcid":"","institution":"Capital medical University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Chunlian","middleName":"","lastName":"Wei","suffix":""},{"id":5489577,"identity":"e8b68c22-8aae-4878-a903-f4593dc7fbb5","order_by":2,"name":"Cuijiao Wu","email":"","orcid":"","institution":"Qingdao University Medical College","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Cuijiao","middleName":"","lastName":"Wu","suffix":""},{"id":5489578,"identity":"3feee658-a91d-4255-8627-3ed89c1d082c","order_by":3,"name":"Mengmeng Han","email":"","orcid":"","institution":"The Affiliated Hospital of Qingdao University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Mengmeng","middleName":"","lastName":"Han","suffix":""},{"id":5489579,"identity":"b0404cfc-6346-4d57-b6b6-e5d3ab76c256","order_by":4,"name":"Jingli Wang","email":"","orcid":"","institution":"The Affiliated Hospital of Qingdao University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Jingli","middleName":"","lastName":"Wang","suffix":""},{"id":5489580,"identity":"53cdf822-261a-40ff-a2cd-a1e59a7cca71","order_by":5,"name":"Huabin Hou","email":"","orcid":"","institution":"The Affiliated Hospital of Qingdao University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Huabin","middleName":"","lastName":"Hou","suffix":""},{"id":5489581,"identity":"9321c496-28ff-4ed3-a875-cf1f6b6f9241","order_by":6,"name":"Lu Zhang","email":"","orcid":"","institution":"The Affiliated Hospital of Qingdao University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Lu","middleName":"","lastName":"Zhang","suffix":""},{"id":5489582,"identity":"e5a3eb73-f20f-47ba-9f99-c6707dd69a45","order_by":7,"name":"Shiguo Liu","email":"","orcid":"","institution":"The Affiliated Hospital of Qingdao University","correspondingAuthor":false,"submittingAuthor":false,"prefix":"","firstName":"Shiguo","middleName":"","lastName":"Liu","suffix":""},{"id":5489583,"identity":"1649de78-5c75-49a6-a958-12df53b208eb","order_by":8,"name":"Ying Chen","email":"data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAZAAAAAyAQMAAABI0h/eAAAABlBMVEX///8AAABVwtN+AAAACXBIWXMAAA7EAAAOxAGVKw4bAAAA1UlEQVRIiWNgGAWjYBACNvbmgw8SKiR4+CGMGsJa+HiOJRs8OGMjI9kDZhwjrEVOIkdN8GFbmo3BjBw1yYctzEQ4jOcMG0PCmcM8BhI5bBWJDWwM/O3dCQT80nsM6IXDPOY8b4/dSNwhwyBx5uwGAracSzcA2WLZnpd2IxFopYFELgEtEjlmEoltQIcdyDErSGxjJlpLGo/BiRwzBuK0gAI54YwNDyiQJRLOHOMh6Bf59uaDD39USNiDovLjj4oaOf72XvxaMAAPacpHwSgYBaNgFGAFANrDTn04CzKJAAAAAElFTkSuQmCC","orcid":"","institution":"the Affiliated Hospital of Qingdao University","correspondingAuthor":true,"submittingAuthor":false,"prefix":"","firstName":"Ying","middleName":"","lastName":"Chen","suffix":""}],"badges":[],"createdAt":"2020-08-19 10:39:28","currentVersionCode":3,"declarations":"","doi":"10.21203/rs.3.rs-62203/v3","doiUrl":"https://doi.org/10.21203/rs.3.rs-62203/v3","draftVersion":[],"editorialEvents":[{"content":"https://doi.org/10.1186/s12884-020-03459-w","type":"published","date":"2020-12-07T15:01:14+00:00"}],"editorialNote":"","failedWorkflow":false,"files":[{"id":15670313,"identity":"b372b019-61d4-487b-9f24-d9f2dcd1da2c","added_by":"auto","created_at":"2021-11-18 13:58:29","extension":"pdf","order_by":0,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":433725,"visible":true,"origin":"","legend":"","description":"","filename":"manuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-62203/v3/713addc7-e1d5-4b70-ac28-ec81f5def519.pdf"},{"id":4107813,"identity":"4e96cf7a-0dad-452a-b49e-f3d6395f067b","added_by":"auto","created_at":"2020-12-08 20:30:19","extension":"docx","order_by":1,"title":"","display":"","copyAsset":false,"role":"supplement","size":16256,"visible":true,"origin":"","legend":"Additional file 1:\nsupplemental table. The demographic and clinical characteristics of GDM and controls","description":"","filename":"supplementaltable.docx","url":"https://assets-eu.researchsquare.com/files/rs-62203/v3/e2d542c942aba6a51e261d51.docx"}],"financialInterests":"","formattedTitle":"\u003cp\u003ePolymorphisms\u0026nbsp;of\u0026nbsp;\u003cem\u003eTGF-β1\u003c/em\u003e\u0026nbsp;and\u0026nbsp;\u003cem\u003eTGF-β3\u003c/em\u003e\u0026nbsp;in Chinese women with Gestational Diabetes Mellitus\u003c/p\u003e","fulltext":[{"header":"Background","content":"\u003cp\u003eGDM is the most common maternal metabolic disturbance that is defined as glucose intolerance of variable severity with onset or first detection during pregnancy[1, 2]. The prevalence of GDM varies from 1%-22% of all pregnancies depending on different populations and diagnostic criteria[3-5]. GDM not only increases the risk of maternal and fetal perinatal complications, but also has long-term adverse consequences for offspring [6, 7]. The most familiar complication following GDM is PE which shares common clinical risk factors with GDM such as obesity, advanced maternal age and diabetes[8]. GDM is characterized by increased insulin resistance and defective insulin secretion which is due to the inability of pancreatic \u0026beta; cells[2]. However, the etiology is complex due to disordered metabolism and intrauterine environment during pregnancy. Extensive efforts have been made to explore the pathogenesis and to find new targets for prediction of GDM[2, 9, 10].\u003c/p\u003e\n\u003cp\u003eThe TGF-\u0026beta; superfamily, including TGF-\u0026beta; isoforms, activins, inhibins and bone morphogenetic proteins（BMPs), is involved in a myriad of biological processes such as cell proliferation, differentiation and death[11]. In addition, TGF-\u0026beta; signaling has been indicated to play key roles in the development of GDM and GDM risk factors. BMPs disfunction will impair insulin signal and glucose homeostasis in the setting of diabetes[12]. Activins can promote the proliferation of pancreatic \u0026beta;-cell and secretion of insulin[13]. TGF-\u0026beta; isoforms are known to stimulate adipocyte proliferation, insulin resistance and subclinical inflammation[14].\u003c/p\u003e\n\u003cp\u003eIn recent years, the role of genetic factors in the pathogenesis of GDM has been increasingly investigated. The major genetic studies of GDM are candidate gene studies, which have revealed that some single nucleotide polymorphisms (SNPs) in cytokine genes are associated with susceptibility to GDM [15, 16]. SNPs within the coding and signal sequences can affect gene transcriptional activity, and then change the production of proteins[17]. Several studies have reported that altered cytokines expression are related to the severity and progression of the GDM[18, 19]. Therefore, the cytokine genes with positive SNP loci may be a pregnancy biomarker for screening GDM.\u003c/p\u003e\n\u003cp\u003eTGF-\u0026beta;1 and TGF-\u0026beta;3 belong to TGF-\u0026beta; isoforms and have differential expression in the human endometrium and placenta[11]. Both of them contribute to normal homeostasis of pancreas and insulin action[20]. The enhanced expression of TGF-\u0026beta;1 induced by hyperglycemia was detected in individuals with GDM[21, 22]. Although there is no direct relation between TGF-\u0026beta;3 and GDM, TGF-\u0026beta;3 participates in many GDM complications such as PE and pregnancy-induced hypertension[23]. Three tag SNPs (rs4803455, rs2284792, and rs3917201), located in introns of \u003cem\u003eTGF-\u0026beta;1\u003c/em\u003e and \u003cem\u003eTGF-\u0026beta;3\u003c/em\u003e locus respectively, can affect the transcriptional activity and change the expression of proteins[24-26]. Therefore, we supposed that these three SNPs might be target SNPs, and try to investigate the relationship between polymorphisms of \u003cem\u003eTGF-\u0026beta;1\u003c/em\u003e, \u003cem\u003eTGF-\u0026beta;3\u003c/em\u003e and the risk of GDM.\u003c/p\u003e"},{"header":"Methods","content":"\u003cp\u003e\u003cstrong\u003eSubjects \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis study was conducted based on 919 pregnant women with GDM and 1177 healthy pregnant women with normal glucose tolerance, recruited from the clinical pregnancy registries at the Affiliated Hospital of Qingdao University, People\u0026rsquo;s Hospital of Liaocheng City and People's Hospital of Linyi City. Informed consent was issued and signed by all subjects and all investigations were approved by the ethics committee of the Affiliated Hospital of Qingdao University.\u003c/p\u003e\n\u003cp\u003eAll the participants underwent a 75 g oral glucose tolerance test (OGTT) at 24\u0026ndash;28 weeks' gestation. The diagnosis of GDM was based on the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria when one of the following plasma glucose values in the OGTT was met or exceeded, fasting plasma glucose 92 mg/dl (5.1 mmol/l), 1h plasma glucose 180 mg/dl (10.0 mmol/l) and 2h plasma glucose 153 mg/dl (8.5 mmol/l). Plasma glucose during OGTT of the follow-up study was measured by enzymatic hexokinase photometric assay. Exclusion criteria included heart diseases, chronic hypertension, diabetes mellitus, thyroid diseases, kidney disorders, abnormal liver function, twin or multiple pregnancies, as well as in-vitro fertilization in the present gestation. Women were recruited in the study group when first diagnosed as GDM at 24-28 weeks\u0026rsquo; gestation. Then, they were taken blood for testing before diet control and insulin therapy. Besides, 919 GDM patients were categorized into 455 without PE and 464 with PE which was determined on the base of the questionnaire, clinical features, and data. A newly onset of hypertension (\u0026ge;140/90 mmHg) with proteinuria C of 300mg or higher in 24-hour after 20 weeks of gestation was diagnosed as PE.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eGenomic DNA was extracted from peripheral venous blood by alkaline lysis method and collected by centrifugal column in the Qiagen blood DNA extraction kit (Qiagen, Hilden, Germany). TaqMan allelic discrimination real-time PCR (Life Technologies, Grand Island, NY, USA) was used to genotype the polymorphisms of rs4803455 in \u003cem\u003eTGF-\u0026beta;1\u003c/em\u003e, rs2284792 and rs3917201 in \u003cem\u003eTGF-\u0026beta;3\u003c/em\u003e. The TaqMan probes and primers were designed by Applied Bio-systems or Life Technologies (New York. USA). \u003cem\u003eTGF-\u0026beta;1\u003c/em\u003e and \u003cem\u003eTGF-\u0026beta;3\u003c/em\u003e were amplified using the following primers: 5\u0026rsquo;-GCTGCAAACATTCTGGGGTTT-3\u0026rsquo; for TGF-\u0026beta;1 rs4803455, 5\u0026rsquo;-GGGTGGGACCAGGGAATCT-3\u0026rsquo; for TGF-\u0026beta;3 rs2284792 and 5\u0026rsquo;-CGCCTCAAGAAGCAGAAGGAT-3\u0026rsquo; for TGF-\u0026beta;3 rs3917201. Reaction volume was 25\u0026mu;l: 1.25\u0026mu;L 20 \u0026times; SNP Genotyping Assay, 12.5\u0026mu;L 2 \u0026times; PCR Master Mix, and 11.25\u0026mu;L DNA and DNase-free water. 1000\u0026trade; Thermal cycler and CFX96\u0026trade; Real-time system (Bio-Rad, California, USA) were carried out to amplifications as following conditions: 95\u0026deg;C for 3 min, followed by 45 cycles at 95\u0026deg;C for 15 s and 60\u0026deg;C for 1 min. The fluorescent signals from VIC/FAM-labeled probes were detected for each cycle. Discrimination of genotypes was conducted with BioRad CFX manager 3.0 software.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eStatistical analysis\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eStatistical software package IBM SPSS 22.0 (SPSS Inc., Chicago, IL, USA) was used to manipulate all data. Student\u0026rsquo;s \u003cem\u003et\u003c/em\u003e-test was utilized to compare the demographic and clinical characteristics of cases and controls. An analysis of variance (ANOVA) was used to conduct the genotype-phenotype analysis. A chi-square test was performed to assess the HWE in the controls. Allelic and genotypic distributions were enrolled in the comparison by using Pearson\u0026rsquo;s \u0026chi;\u0026sup2; test which was substituted with Fisher\u0026rsquo;s exact test when expected values were below 5. \u003cem\u003eP\u003c/em\u003e \u0026lt; 0.05 (two-sided) was considered to represent statistically significance. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to reveal the relative risk degree. A \u003cem\u003eP\u003c/em\u003e-value \u0026lt; 0.05 (two-sided) was taken as statistical significance for all statistical analyses.\u003c/p\u003e"},{"header":"Results","content":"\u003cp\u003e\u003cstrong\u003eDemographic and clinical characteristics of GDM and controls\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eSubjects were categorized into 919 GDM patients and 1177 controls. Demographic and clinical data of different groups were summarized in the supplemental table.\u003c/p\u003e\n\u003cp\u003eBoth groups had similar age distribution, times of gravidity, and number of abortions. The mean age of cases and controls was 30.71\u0026plusmn;4.18 and 30.75\u0026plusmn;4.21 years old. However, in GDM group, weeks of admission and delivery intended to be earlier (P\u0026lt;0.001) and the weight gain of newborns was heavier than in the control group as expected (P\u0026lt;0.001).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eTGF-\u0026beta;1 \u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003eand\u003cem\u003e TGF-\u0026beta;3\u003c/em\u003e polymorphism analysis \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe subjects of the control group enrolled in this study were in accordance with HWE for these SNPs and displayed a group representative at the significance level of P＞0.05.\u003c/p\u003e\n\u003cp\u003eThe distributions of the genotypes and alleles in GDM cases and controls were reported in Table 1. We observed a statistically significant difference between GDM and healthy women in the frequencies of \u003cem\u003eTGF-\u0026beta;3\u003c/em\u003e rs2284792 (\u0026chi;\u0026sup2; =9.064, P =0.011). However, no statistical differences were detected either in \u003cem\u003eTGF-\u0026beta;1\u003c/em\u003e rs4803455 or in \u003cem\u003eTGF-\u0026beta;3\u003c/em\u003e rs3917201 between two groups in terms of genotypic frequencies. As shown in Table 1, the allelic frequencies of rs2284792 between two groups were not obviously different (\u0026chi;\u0026sup2; =1.592, P =0.207, OR=1.082, 95%CI 0.957-1.224). When categorized into three models (AA \u003cem\u003evs\u003c/em\u003e AG+GG, GG \u003cem\u003evs\u003c/em\u003e AG+AA and AG \u003cem\u003evs\u003c/em\u003e GG+AA), there was a significant difference between these two groups (For AA \u003cem\u003evs\u003c/em\u003e AG+GG model, \u0026chi;\u0026sup2;=6.314, P=0.012, OR 1.270, 95%CI 1.054-1.530; For AG \u003cem\u003evs\u003c/em\u003e GG+AA model, \u0026chi;\u0026sup2;=8.545, P=0.003, OR=0.773, 95%CI 0.650-0.919). Consistently, allelic frequencies of TGF-\u0026beta;1 rs4803455 or TGF-\u0026beta;3 rs3917201 were statistically insignificant.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cem\u003eTGF-\u0026beta;1 \u003c/em\u003e\u003c/strong\u003e\u003cstrong\u003eand\u003cem\u003e TGF-\u0026beta;3\u003c/em\u003e polymorphism analysis between GDM patients with and without PE\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eTo further study the association between variants of the three SNPs and complications, samples were categorized into GDM cases with and without PE. The distributions of the genotypes and alleles in GDM patients with and without PE are shown in Table 2 and Table 3.\u003c/p\u003e\n\u003cp\u003eIn GDM cases without PE group, the statistical difference between cases and controls in genotypic distributions of TGF-\u0026beta;3 rs2284792 was observed (\u0026chi;\u0026sup2;=9.774, P =0.008). Also, the same was found for allelic frequencies in AA \u003cem\u003evs\u003c/em\u003e AG+GG (\u0026chi;\u0026sup2;=8.476, P =0.004 OR=1.427, 95%CI 1.122-1.813) and AG \u003cem\u003evs\u003c/em\u003e GG+AA (\u0026chi;\u0026sup2;=7.842, P =0.005 OR=0.734, 95%CI 0.590-0.912). In contrast to TGF-\u0026beta;3 rs2284792, no obvious difference was found in either the genotypic distributions or allelic frequencies of \u003cem\u003eTGF-\u0026beta;1\u003c/em\u003e rs4803455 and TGF-\u0026beta;3 rs3917201 among GDM only cases.\u003c/p\u003e\n\u003cp\u003eIn GDM cases with PE group, however, no obvious difference was found in either the genotypic distributions or allelic frequencies of three SNPs (for rs4803455, \u0026chi;\u0026sup2;=1.266, P =0.531 by genotype, \u0026chi;\u003csup\u003e2\u003c/sup\u003e =0.069, P =0.793, OR =1.021, 95%CI 0.873-1.194 by allele; when for rs2284792, \u0026chi;\u003csup\u003e2\u003c/sup\u003e =3.619, P =0.164 by genotype, \u0026chi;\u003csup\u003e2\u003c/sup\u003e =0.021, P =0.885, OR =1.011, 95%CI 0.867-1.1791by allele; and for rs3917201, \u0026chi;\u003csup\u003e2\u003c/sup\u003e =0.359, P =0.836 by genotype, \u0026chi;\u003csup\u003e2\u003c/sup\u003e =0.015, P =0.903, OR =1.009, 95%CI 0.867-1.175 by allele).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAnalysis of Genotype-Phenotype Relationship\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAnalysis of the relationship between the genotypes of TGF-\u0026beta;3 rs2284792 and demographic characteristics among total GDM patients was shown in Table 4. However, no statistical differences were found for the genotype-phenotype relationship of rs2284792.\u0026nbsp;\u003c/p\u003e"},{"header":"Discussion","content":"\u003cp\u003eIn this study, the associations between \u003cem\u003eTGF-\u0026beta;1\u003c/em\u003e, \u003cem\u003eTGF-\u0026beta;3\u003c/em\u003e polymorphisms and GDM were examined in a Chinese population. Among women with GDM, we firstly found an effective association between the tag SNP TGF-\u0026beta;3 rs2284792 and GDM risk. Besides, we confirmed that the A allele and the AA and AG genotypes were susceptible, while the G allele/GG genotype may be protective factors. However, there were no statistically significant differences in the distribution of TGF-\u0026beta;1 rs4803455 and TGF-\u0026beta;3 rs3917201 genotypes between GDM and healthy women.\u003c/p\u003e\n\u003cp\u003ePrevious genetic study of GDM is to find candidate genes that was based on biological plausibility[27]. Recently, genome-wide association analysis studies were performed to identify some susceptibility genes associated with GDM[4]. The genetic variants of candidate genes have been revealed to contribute to the risk of GDM. For example, rs12255372 variant in\u003cem\u003e Transcription factor 7-like 2\u003c/em\u003e was indicated to interact with adiposity to alter \u0026beta;-cell function in 132 Mexican-American families with GDM[28]. The homozygosity for \u003cem\u003eG972R\u003c/em\u003e polymorphism in\u003cem\u003e Insulin receptor substrate-1\u003c/em\u003e might indicate an increased risk for GDM in Saudi women[29]. There was also was significantly associated with genotypes and alleles of the CC chemokine ligand 2 rs1024611 and rs4586 polymorphisms[18] and GDM. Interestingly, many GDM associated candidate genes can express cytokines implicated in the inflammatory conditions during pregnancy[30].\u003c/p\u003e\n\u003cp\u003eGDM is characterized by varying degrees of hyperglycemia due to the inability of pancreatic \u0026beta;-cells to adequately respond to the increased insulin requirements during the second and third trimester[31, 32]. The etiology of GDM may be explained by many factors including cytokines, hormones, lifestyle as well as genetic disposition[33]. TGF-\u0026beta; isoforms are multifunctional factors that regulate embryonic development, immunity, and epithelial homeostasis[34]. Genetic polymorphisms of TGF-\u0026beta; isoforms were linked with an increased likelihood of having GDM and complications such as PE and diabetic nephropathy[15, 35]. With such attributes, we chose \u003cem\u003eTGF-\u0026beta;1\u003c/em\u003e and \u003cem\u003eTGF-\u0026beta;3\u003c/em\u003e as target genes to uncover the genetic disposition of GDM.\u003c/p\u003e\n\u003cp\u003eTGF-\u0026beta;1 is reported to be a key cytokine in insulin resistance and obesity. Over-expression of TGF-\u0026beta;1 can lead to decreased \u0026beta;-cell mass and insulin secretion[36]. TGF-\u0026beta;1 rs4803455 polymorphism is an A/C single-nucleotide variation on chromosome 19q13.2 and can alter the expression of insulin receptor substrate 2 associated with insulin resistant in GDM, but not depending on its expression in the pathway[37]. Moreover, a previous study suggested that TGF-\u0026beta;1 rs4803455 showed the effectiveness to capture the associations with cancer risk[38]. However, our data revealed that TGF-\u0026beta;1 rs4803455 was not a significant risk factor of GDM in the Chinese Population. The difference between these studies could be attributed to the discordance of population genetic background. However, the finite sample size in these studies is another limiting factor to have a coincident conclusion.\u003c/p\u003e\n\u003cp\u003eThis is the first study to show the relationship between the genetic polymorphism of \u003cem\u003eTGF-\u0026beta;3\u003c/em\u003e gene and GDM. Candidate SNPs previously described were chosen based on their location within the gene, and a tag SNP (rs2284792: A\u0026gt;G) selected with SNP picker using data from the Caucasian population was located within the introns of \u003cem\u003eTGF-\u0026beta;3\u003c/em\u003e [39]. Our studies revealed an effective association between the tag SNP rs2284792 and GDM risk. Besides, we confirmed that the A allele and the A allele-containing genotypes (AA and AG) were susceptible, while the G allele/GG genotype may be protective factors. TGF-\u0026beta;s in mammals exhibit many overlapping biological activities and appear interchangeable. TGF-\u0026beta;3 knock-in ameliorate inflammation due to TGF-\u0026beta;1 deficiency while promoting glucose tolerance[40]. Reduced TGF-\u0026beta;3 expression can cause hypertrophy and induce glucose intolerance[41]. Therefore, altered generation made by polymorphic variants in \u003cem\u003eTGF-\u0026beta;3\u003c/em\u003e may affect glucose homeostasis, thus leading to GDM.\u003c/p\u003e\n\u003cp\u003eGDM is a transient presentation of long-standing metabolic malfunction and may be expected to have an association with PE[42]. The pathophysiology of PE is characterized by endothelial dysfunction which may be induced by down-regulation of TGF-\u0026beta; signaling. TGF-\u0026beta; isoforms were predisposed to have obvious susceptible associations with PE and were supposed as a biomarker for assessment of PE severity[43, 44]. \u003cem\u003eTGF-\u003c/em\u003e\u003cem\u003e𝛽\u003c/em\u003e\u003cem\u003e1\u003c/em\u003e codon 10T/C was observed to have a higher frequency of T＞C allele in Type 2 Diabetes Mellitus patients with hypertension[45]. A fetal \u003cem\u003eTGF-\u0026beta;3\u003c/em\u003e variant (rs11466414) is associated with PE in a predominantly Hispanic population[44]. In consideration of comparable clinical characteristics, we hypothesized that the variants of TGF-\u0026beta; isoforms may relate to the development of both disease conditions. Then, we analyzed \u003cem\u003eTGF-\u0026beta;1\u003c/em\u003e (rs4803455) and \u003cem\u003eTGF-\u0026beta;3\u003c/em\u003e (rs2284792 and rs3917201) polymorphisms among GDM cases with PE. However, no obvious difference was found in either the genotypic distributions or allelic frequencies among above three SNPs. The complexity of several pathogenic pathways including metabolic, immune, and endothelial dysfunction can account for the invalid assumption. Insulin resistance which is highly prevalent in patients with GDM can only partially explain the development of PE[42]. To sum up, TGF-\u0026beta;3 rs2284792 may be the independent effective genetic locus for GDM alone.\u003c/p\u003e"},{"header":"Conclusions","content":"\u003cp\u003eThis study indicated that the AA and AG genotype rs2284792 polymorphism of \u003cem\u003eTGF-\u0026beta;3\u003c/em\u003e was associated with the increased risk of GDM. However, some evident shortcomings are the limited sample size and the different ethnic origins. Furthermore, some environmental factors, such as behavioral and pharmacological interventions, will be considered in our future studies. All these studies highlight the need of long-term cohort studies of women with GDM for ultimately improving pregnancy outcomes.\u0026nbsp;\u003c/p\u003e"},{"header":"Declarations","content":"\u003cp\u003e\u003cstrong\u003eEthics approval and consent to participate\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eInformed consent was issued and signed by all subjects and all investigations were approved by the ethics committee of the Affiliated Hospital of Qingdao University.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConsent for publication\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAvailability of data and materials\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe original data used to support the findings of this study are available from the corresponding author upon request.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCompeting interests \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThe authors declare that they have no competing interests.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eFunding\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eThis work was supported by Natural Science Fund Project of Shandong Province [ZR2019MH127]; Key research and development plan of Shandong Province [ 2019GSF108106] and the Application and Basic Research Project of Qingdao[18-2-2-27-jch]. The funding body did not play a role in the design of the study or in the collection, analysis, and interpretation of data or in writing the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthors\u0026rsquo; contributions \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eYLX: study design, protocol development; CJW, MMH, JLW and HBH: collecting clinical samples; YLX and CLW: data analysis; YLX: writing the manuscript; LZ, YC and SGL: critical review of the manuscript; YC and SGL is responsible for the integrity and the accuracy of the data analysis. All authors have read and approved the final version of the manuscript.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAcknowledgments \u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eNot applicable.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAdditional file\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAdditional file 1: supplemental table. The demographic and clinical characteristics of GDM and controls\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eAuthor details\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003e\u003csup\u003e1\u003c/sup\u003eDepartment of Medical Genetic, the Affiliated Hospital of Qingdao University, 266000, Qingdao, China. \u003csup\u003e2\u003c/sup\u003ePrenatal Diagnosis Center, the Affiliated Hospital of Qingdao University, 266000, Qingdao, China. \u003csup\u003e3\u003c/sup\u003eDepartment of Immunology, School of Basic Medical Sciences, Capital Medical University, 100000, Beijing, China. \u003csup\u003e4\u003c/sup\u003eDepartment of Histology and Embryology, Qingdao University Medical College, 260000, Qingdao, China.\u003csup\u003e 5\u003c/sup\u003eDepartment of Clinical laboratory, the Affiliated Hospital of Qingdao University, Qingdao, China. \u003csup\u003e6\u003c/sup\u003eDepartment of Endocrinology and Metabolism, the Affiliated Hospital of Qingdao University, 266000, Qingdao, China.\u003c/p\u003e"},{"header":"Abbreviations","content":"\u003cp\u003eTGF-\u0026beta;: Transforming growth factor-\u0026beta;; GDM: Gestational diabetes mellitus; HWE: Hardy-Weinberg equilibrium; PE: preeclampsia; SNPs: Signal Nucleotide Polymorphisms; OGTT: oral glucose tolerance test; ORs: Odds ratios; Cis: confidence intervals\u003c/p\u003e"},{"header":"References","content":"\u003col\u003e\n\u003cli\u003eLowe, W.L., Jr., D.M. 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Ovesen.Gestational diabetes: A clinical update.World J Diabetes.2015;\u003cstrong\u003e6\u003c/strong\u003e(8):1065-72.\u003c/li\u003e\n\u003cli\u003eFernandez-Real, J.M., J.C. Pickup.Innate immunity, insulin resistance and type 2 diabetes.Diabetologia.2012;\u003cstrong\u003e55\u003c/strong\u003e(2):273-8.\u003c/li\u003e\n\u003cli\u003eYamanaka, Y., H. Friess, M. Buchler, H.G. Beger, L.I. Gold,M. Korc.Synthesis and expression of transforming growth factor beta-1, beta-2, and beta-3 in the endocrine and exocrine pancreas.Diabetes.1993;\u003cstrong\u003e42\u003c/strong\u003e(5):746-56.\u003c/li\u003e\n\u003cli\u003eConti, E., L. Zezza, E. Ralli, D. Caserta, M.B. Musumeci, M. Moscarini, C. Autore,M. Volpe.Growth factors in preeclampsia: a vascular disease model. A failed vasodilation and angiogenic challenge from pregnancy onwards?Cytokine Growth Factor Rev.2013;\u003cstrong\u003e24\u003c/strong\u003e(5):411-25.\u003c/li\u003e\n\u003cli\u003eYadav, H., S. Devalaraja, S.T. Chung,S.G. 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Ingles.Maternal and fetal variants in the TGF-beta3 gene and risk of pregnancy-induced hypertension in a predominantly Latino population.Am J Obstet Gynecol.2009;\u003cstrong\u003e201\u003c/strong\u003e(3):295 e1-5.\u003c/li\u003e\n\u003cli\u003eRamirez, A., M. Hernandez, R. Suarez-Sanchez, C. Ortega, J. Peralta, J. Gomez, A. Valladares, M. Cruz, M.A. Vazquez-Moreno,F. Suarez-Sanchez.Type 2 diabetes-associated polymorphisms correlate with SIRT1 and TGF-beta1 gene expression.Ann Hum Genet.2020;\u003cstrong\u003e84\u003c/strong\u003e(2):185-194.\u003c/li\u003e\n\u003c/ol\u003e"},{"header":"Tables","content":"\u003cp style=\"margin: 2pt 7.5pt 0.0001pt 11pt;font-size:14px;font-family: DengXian;line-height: 15.539999961853027px;text-align: left;\"\u003e\u003cstrong\u003e\u003cspan style=\"font-size: 11px; line-height: 17.760000228881836px; font-family: Verdana, Geneva, sans-serif; color: rgb(0, 0, 0);\"\u003eTable\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 17.760000228881836px;\"\u003e1\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 17.760000228881836px;\"\u003eThe comparison of genotypic and allelic frequencies of all SNPs\u0026nbsp;between GDM (all cases) and\u0026nbsp;controls\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"margin-left: 5.6pt;border-collapse: collapse;\" width=\"568\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;border-top-width: 1pt;border-style: 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none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 1.25pt 0in 0.0001pt 15.65pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003ep-value\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 1.25pt 0in 0.0001pt 17.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan 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16.35pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 1.1pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003ers4803455\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eGenotypes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 27.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e142\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;padding: 0in;height: 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width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 27.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e412\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.02112676056338%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e556\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.67605633802817%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 27.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e365\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.02112676056338%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e448\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.67605633802817%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAlleles\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 27.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e696\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.02112676056338%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e902\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.67605633802817%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 14.85pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.089\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 20.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.766\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 13.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1.019\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 9.35pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.899-1.156\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 25.55pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1142\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.02112676056338%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1452\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.67605633802817%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003ers2284792\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eGenotypes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 27.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e268\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.02112676056338%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e404\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.67605633802817%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 14.85pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e9.064\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 18.05pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.011*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: 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style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 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11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAG+AA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 27.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e755\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.02112676056338%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e952\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.67605633802817%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 15.1pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.511\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 20.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.458\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 13.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1.088\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 9.35pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.871-1.360\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 27.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e487\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.02112676056338%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e548\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.67605633802817%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eGG+AA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 27.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e432\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.02112676056338%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e629\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.67605633802817%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 14.85pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e8.545\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 17.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.003*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 13.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.773\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 9.35pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.650-0.919\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAlleles\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 25.35pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1023\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.02112676056338%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1356\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.67605633802817%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 14.85pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1.592\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 20.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.207\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 13.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1.082\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 9.35pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.957-1.224\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 27.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e815\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.02112676056338%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e998\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.67605633802817%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003ers3917201\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eGenotypes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eGG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 27.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e220\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.02112676056338%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e294\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.67605633802817%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 14.85pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.303\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 20.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.895\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 27.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e468\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.02112676056338%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e592\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.67605633802817%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 27.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e231\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.02112676056338%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e291\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.67605633802817%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAlleles\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 27.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e908\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.02112676056338%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.35pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1180\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.67605633802817%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 14.85pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.218\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 20.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.641\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 13.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1.029\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 9.55pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.911-1.163\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 64.75pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"15.140845070422536%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 63.3pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 27.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e930\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 68.3pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"16.02112676056338%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.35pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1174\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 54.3pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"12.67605633802817%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.85pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"14.788732394366198%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 46.9pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"11.091549295774648%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 65.8pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"15.492957746478874%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 1.1pt 7.5pt 0.0001pt 11pt;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e*p \u0026lt; 0.05 is considered statistically significant, OR ODDs ratio, CI Confidence interval\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in;font-size:14px;font-family: DengXian;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 2pt 2.5pt 0.0001pt 11pt;font-size:14px;font-family: DengXian;line-height: 15.539999961853027px;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 17.760000228881836px;\"\u003eTable\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 17.760000228881836px;\"\u003e2\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 17.760000228881836px;\"\u003eThe comparison of genotypic and allelic frequencies of all SNPs\u0026nbsp;between GDM without PE and\u0026nbsp;controls\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"margin-left: 5.6pt;border-collapse: collapse;\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 1.6pt 0in 0.0001pt 13.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eCases\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 1.6pt 0in 0.0001pt 9.1pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eControls\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 1.6pt 1.15pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u003cem\u003e\u0026chi;2\u003c/em\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 1.6pt 0in 0.0001pt 14.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003ep-value\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 1.6pt 0.9pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eOR\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 1.6pt 0in 0.0001pt 24.1pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e95%CI\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 409.5pt;border: none;padding: 0in;height: 16.35pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 1.45pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003ers4803455\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 409.5pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eGenotypes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 3.95pt;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e70\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 3.95pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e173\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 13.05pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.631\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 19.05pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.730\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 18.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e205\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 3.95pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e556\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 18.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e180\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 3.95pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e448\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 409.5pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAlleles\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 18.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e345\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 3.95pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e902\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 13.05pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.046\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 19.05pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.831\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 14.1pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1.017\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 14.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 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11px;\"\u003e565\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 0.25in;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1452\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 409.5pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003ers2284792\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 409.5pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eGenotypes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 1pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 1pt 0in 0.0001pt 18.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e122\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 1pt 3.95pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e404\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 1pt 0in 0.0001pt 13.05pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e9.774\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 1pt 0in 0.0001pt 16.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.008*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 18.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e247\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 3.95pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e548\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eGG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 3.95pt;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e86\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 3.95pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e225\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 18.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e122\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 3.95pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e404\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 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11px;\"\u003e0.005*\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 14.1pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.734\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 14.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.590-0.912\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 409.5pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAlleles\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 18.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e491\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 0.25in;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1356\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 13.05pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e3.555\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 19.05pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.059\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 14.1pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1.159\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 14.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.994-1.352\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 18.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e419\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 3.95pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e998\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 409.5pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 1pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003ers3917201\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 409.5pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eGenotypes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eGG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 18.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e108\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 3.95pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e294\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 13.05pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.571\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 19.05pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.752\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 18.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e227\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 3.95pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e592\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 18.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e120\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 3.95pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e291\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 409.5pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAlleles\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 18.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e443\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 18.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1180\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 13.05pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.549\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 19.05pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.459\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 14.1pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1.060\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 14.95pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.909-1.235\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 54.95pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"13.394495412844037%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 48.15pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"11.743119266055047%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 18.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e467\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 0.85in;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0.95pt 0in 0.0001pt 18.25pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1174\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 51.15pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"12.477064220183486%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 61.75pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"15.045871559633028%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.85pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"12.844036697247706%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 79.45pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"19.44954128440367%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 1.45pt 2.5pt 0.0001pt 11pt;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e*p \u0026lt; 0.05 is considered statistically significant, OR ODDs ratio, CI Confidence interval\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 0in;font-size:14px;font-family: DengXian;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 2pt 7.5pt 0.0001pt 11pt;font-size:14px;font-family: DengXian;line-height: 15.539999961853027px;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 17.760000228881836px;\"\u003eTable\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cstrong\u003e\u003cspan style=\"line-height: 17.760000228881836px;\"\u003e3\u0026nbsp;\u003c/span\u003e\u003c/strong\u003e\u003cspan style=\"line-height: 17.760000228881836px;\"\u003eThe comparison of genotypic and allelic frequencies of all SNPs\u0026nbsp;between GDM with PE and\u0026nbsp;controls\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"margin-left: 5.6pt;border-collapse: collapse;\" width=\"568\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 1.25pt 0in 0.0001pt 32.6pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eCases\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 1.25pt 0in 0.0001pt 13.7pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eControls\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 1.25pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e\u003cem\u003e\u0026chi;2\u003c/em\u003e\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 1.25pt 0in 0.0001pt 14.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003ep-value\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 1.25pt 0in 0.0001pt 18.1pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eOR\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;border-top-width: 1pt;border-style: solid none;border-top-color: black;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 16.1pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 1.25pt 0in 0.0001pt 20.15pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e95%CI\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.25pt;border: none;padding: 0in;height: 16.35pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 1.1pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003ers4803455\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.25pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eGenotypes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 40.15pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e72\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e173\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 14.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1.266\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 19.55pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.531\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 37.65pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e207\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e556\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 37.65pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e185\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e448\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.25pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAlleles\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 37.65pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e351\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e902\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eC\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 37.65pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e577\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1452\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.25pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003ers2284792\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.25pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eGenotypes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 37.65pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e146\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e404\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 14.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e3.619\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 19.55pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.164\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 37.65pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e240\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e548\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eGG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 40.15pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e78\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e225\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.25pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAlleles\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 37.65pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e532\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1356\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 14.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.021\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 19.55pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.885\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 14.35pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1.011\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 11.15pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.867-1.179\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 37.65pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e396\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e998\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.25pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003ers3917201\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.25pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eGenotypes\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eGG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 37.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e112\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e294\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 14.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.359\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 19.55pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.836\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 37.65pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e241\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e592\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 38pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e111\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.5pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e291\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"7\" style=\"width: 426.25pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eAlleles\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eA\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 37.65pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e463\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.35pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1180\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 14.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.015\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 19.55pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.903\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 14.15pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1.009\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;padding: 0in;height: 15.6pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 11.15pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.867-1.175\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 53.15pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"12.522045855379188%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eG\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.2pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"16.93121693121693%\"\u003e\n \u003cp style=\"margin: 0.6pt 0in 0.0001pt 37.65pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e465\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 67pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"15.696649029982364%\"\u003e\n \u003cp style=\"margin: 0.6pt 0.35pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e1174\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 52.75pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"12.345679012345679%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 62.3pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"14.638447971781305%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 49.1pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"11.46384479717813%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 69.75pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 15.35pt;vertical-align: top;\" valign=\"top\" width=\"16.402116402116402%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 1.45pt 2.5pt 0.0001pt 11pt;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e*p \u0026lt; 0.05 is considered statistically significant, OR ODDs ratio, CI Confidence interval\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 2.8pt 24.4pt 0.0001pt 11pt;font-size:14px;font-family: DengXian;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cbr\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 2.8pt 24.4pt 0.0001pt 11pt;font-size:14px;font-family: DengXian;text-align: left;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eTable\u0026nbsp;\u003c/strong\u003e\u003cstrong\u003e4\u0026nbsp;\u003c/strong\u003eAssociations between genotypes of rs2284792 and characteristics among total GDM\u0026nbsp;patients.\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003ctable border=\"0\" cellpadding=\"0\" cellspacing=\"0\" style=\"margin-left: 5.55pt;border-collapse: collapse;\" width=\"962\"\u003e\n \u003ctbody\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 116.35pt;border-style: solid none none;border-top-width: 1pt;border-top-color: black;padding: 0in;height: 24.55pt;vertical-align: top;\" valign=\"top\" width=\"16.095534787123572%\"\u003e\n \u003cp style=\"margin: 1.7pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eRs2284792(A/G)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73.4pt;border-style: solid none none;border-top-width: 1pt;border-top-color: black;padding: 0in;height: 24.55pt;vertical-align: top;\" valign=\"top\" width=\"10.176531671858775%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 2.3pt;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eAA\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-style: solid none none;border-top-width: 1pt;border-top-color: black;padding: 0in;height: 24.55pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 2.75pt 0.1pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eAG\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.85pt;border-style: solid none none;border-top-width: 1pt;border-top-color: black;padding: 0in;height: 24.55pt;vertical-align: top;\" valign=\"top\" width=\"9.968847352024921%\"\u003e\n \u003cp style=\"margin: 2.75pt 1pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eGG\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;border-style: solid none none;border-top-width: 1pt;border-top-color: black;padding: 0in;height: 24.55pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 0.1in;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eAA vs.\u0026nbsp;AG\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.1pt;border-style: solid none none;border-top-width: 1pt;border-top-color: black;padding: 0in;height: 24.55pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.55pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eAA vs\u0026nbsp;GG\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.25pt;border-style: solid none none;border-top-width: 1pt;border-top-color: black;padding: 0in;height: 24.55pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.6pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eAG vs\u0026nbsp;GG\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.5pt;border-style: solid none none;border-top-width: 1pt;border-top-color: black;padding: 0in;height: 24.55pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 7.7pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eAA vs\u0026nbsp;AG+GG\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.65pt;border-style: solid none none;border-top-width: 1pt;border-top-color: black;padding: 0in;height: 24.55pt;vertical-align: top;\" valign=\"top\" width=\"10.072689511941848%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 6.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eGG vs\u0026nbsp;AG+AA\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.35pt;border-style: solid none none;border-top-width: 1pt;border-top-color: black;padding: 0in;height: 24.55pt;vertical-align: top;\" valign=\"top\" width=\"10.59190031152648%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eAG vs\u0026nbsp;GG+AA\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 116.35pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 13.6pt;vertical-align: top;\" valign=\"top\" width=\"16.095534787123572%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73.4pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 13.6pt;vertical-align: top;\" valign=\"top\" width=\"10.176531671858775%\"\u003e\n \u003cp style=\"margin: 0in;font-size:15px;font-family: DengXian;text-indent: 31.5pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e(n)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 13.6pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 0in;font-size:15px;font-family: DengXian;text-indent: 31.5pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e(n)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.85pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 13.6pt;vertical-align: top;\" valign=\"top\" width=\"9.968847352024921%\"\u003e\n \u003cp style=\"margin: 0in 1.1pt 0in 0in;font-size:15px;font-family: DengXian;text-indent: 31.5pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003e(n)\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 13.6pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 0in 1.3pt 0in 0in;font-size:15px;font-family: DengXian;text-indent: 22.5pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003eP\u003c/strong\u003e\u003cstrong\u003ea\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.1pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 13.6pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 0in;font-size:15px;font-family: DengXian;text-indent: 27pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003ep\u003c/strong\u003e\u003cstrong\u003eb\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.25pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 13.6pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 0in;font-size:15px;font-family: DengXian;text-indent: 27pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003ep\u003c/strong\u003e\u003cstrong\u003ec\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.5pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 13.6pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 0in;font-size:15px;font-family: DengXian;text-indent: 0.5in;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003ep\u003c/strong\u003e\u003cstrong\u003ed\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.65pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 13.6pt;vertical-align: top;\" valign=\"top\" width=\"10.072689511941848%\"\u003e\n \u003cp style=\"margin: 0in 1.45pt 0in 0in;font-size:15px;font-family: DengXian;text-indent: 0.5in;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003ep\u003c/strong\u003e\u003cstrong\u003ee\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.35pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 13.6pt;vertical-align: top;\" valign=\"top\" width=\"10.59190031152648%\"\u003e\n \u003cp style=\"margin: 0in 1.35pt 0in 0in;font-size:15px;font-family: DengXian;text-indent: 0.5in;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cstrong\u003ep\u003c/strong\u003e\u003cstrong\u003ef\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 116.35pt;border: none;padding: 0in;height: 16.8pt;vertical-align: top;\" valign=\"top\" width=\"16.095534787123572%\"\u003e\n \u003cp style=\"margin: 1.7pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003ecases\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73.4pt;border: none;padding: 0in;height: 16.8pt;vertical-align: top;\" valign=\"top\" width=\"10.176531671858775%\"\u003e\n \u003cp style=\"margin: 1.7pt 0in 0.0001pt 2.55pt;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e268\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border: none;padding: 0in;height: 16.8pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 1.7pt 0.05pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e487\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.85pt;border: none;padding: 0in;height: 16.8pt;vertical-align: top;\" valign=\"top\" width=\"9.968847352024921%\"\u003e\n \u003cp style=\"margin: 1.7pt 0.75pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e164\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;border: none;padding: 0in;height: 16.8pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.1pt;border: none;padding: 0in;height: 16.8pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.25pt;border: none;padding: 0in;height: 16.8pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.5pt;border: none;padding: 0in;height: 16.8pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.65pt;border: none;padding: 0in;height: 16.8pt;vertical-align: top;\" valign=\"top\" width=\"10.072689511941848%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.35pt;border: none;padding: 0in;height: 16.8pt;vertical-align: top;\" valign=\"top\" width=\"10.59190031152648%\"\u003e\n \u003cp style=\"margin: 0in;text-align: justify;font-size:14px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd colspan=\"10\" style=\"width: 721.35pt;padding: 0in;height: 16.5pt;vertical-align: top;\" valign=\"top\" width=\"100%\"\u003e\n \u003cp style=\"margin: 1.7pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eDemographic\u0026nbsp;characteristics (Mean \u0026plusmn; S)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 116.35pt;padding: 0in;height: 37.85pt;vertical-align: top;\" valign=\"top\" width=\"16.095534787123572%\"\u003e\n \u003cp style=\"margin: 1.6pt 18.55pt 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;line-height: 18.773334503173828px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cspan style=\"line-height: 17.920000076293945px;\"\u003eFasting blood\u0026nbsp;glucose (mmol/l)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73.4pt;padding: 0in;height: 37.85pt;vertical-align: top;\" valign=\"top\" width=\"10.176531671858775%\"\u003e\n \u003cp style=\"margin: 1.6pt 0in 0.0001pt 16.6pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e5.90\u0026plusmn;2.13\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;padding: 0in;height: 37.85pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 1.6pt 0in 0.0001pt 14.15pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e5.75\u0026plusmn;2.22\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.85pt;padding: 0in;height: 37.85pt;vertical-align: top;\" valign=\"top\" width=\"9.968847352024921%\"\u003e\n \u003cp style=\"margin: 1.6pt 0in 0.0001pt 14.1pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e5.76\u0026plusmn;2.33\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;padding: 0in;height: 37.85pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 1.6pt 0in 0.0001pt 15.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.087\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.1pt;padding: 0in;height: 37.85pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 1.6pt 0in 0.0001pt 16.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.097\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.25pt;padding: 0in;height: 37.85pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 1.6pt 0in 0.0001pt 16.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.960\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.5pt;padding: 0in;height: 37.85pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 1.6pt 0in 0.0001pt 24.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.059\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.65pt;padding: 0in;height: 37.85pt;vertical-align: top;\" valign=\"top\" width=\"10.072689511941848%\"\u003e\n \u003cp style=\"margin: 1.6pt 0in 0.0001pt 23.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.407\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.35pt;padding: 0in;height: 37.85pt;vertical-align: top;\" valign=\"top\" width=\"10.59190031152648%\"\u003e\n \u003cp style=\"margin: 1.6pt 1.3pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.360\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 116.35pt;padding: 0in;height: 42.6pt;vertical-align: top;\" valign=\"top\" width=\"16.095534787123572%\"\u003e\n \u003cp style=\"margin: 1.2pt 12.8pt 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;line-height: 18.773334503173828px;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u003cspan style=\"line-height: 17.920000076293945px;\"\u003eSystolic blood\u0026nbsp;pressure (mmHg)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73.4pt;padding: 0in;height: 42.6pt;vertical-align: top;\" valign=\"top\" width=\"10.176531671858775%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 8.65pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e137.65\u0026plusmn;22.24\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;padding: 0in;height: 42.6pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 6.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e137.41\u0026plusmn;24.86\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.85pt;padding: 0in;height: 42.6pt;vertical-align: top;\" valign=\"top\" width=\"9.968847352024921%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 6.15pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e137.53\u0026plusmn;22.06\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;padding: 0in;height: 42.6pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 15.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.166\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.1pt;padding: 0in;height: 42.6pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 16.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.425\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.25pt;padding: 0in;height: 42.6pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 16.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.468\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.5pt;padding: 0in;height: 42.6pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 24.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.224\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.65pt;padding: 0in;height: 42.6pt;vertical-align: top;\" valign=\"top\" width=\"10.072689511941848%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 23.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.997\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.35pt;padding: 0in;height: 42.6pt;vertical-align: top;\" valign=\"top\" width=\"10.59190031152648%\"\u003e\n \u003cp style=\"margin: 1.2pt 1.3pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.231\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 116.35pt;padding: 0in;height: 35.45pt;vertical-align: top;\" valign=\"top\" width=\"16.095534787123572%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eDiastolic blood\u0026nbsp;pressure\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 3.5pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e(mmHg)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73.4pt;padding: 0in;height: 35.45pt;vertical-align: top;\" valign=\"top\" width=\"10.176531671858775%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 11.3pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e77.09\u0026plusmn;12.36\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;padding: 0in;height: 35.45pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 9pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e77.17\u0026plusmn;11.86\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.85pt;padding: 0in;height: 35.45pt;vertical-align: top;\" valign=\"top\" width=\"9.968847352024921%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 23.55pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e77.01\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;padding: 0in;height: 35.45pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 15.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.519\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.1pt;padding: 0in;height: 35.45pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 16.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.560\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.25pt;padding: 0in;height: 35.45pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 16.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.137\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.5pt;padding: 0in;height: 35.45pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 24.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.972\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.65pt;padding: 0in;height: 35.45pt;vertical-align: top;\" valign=\"top\" width=\"10.072689511941848%\"\u003e\n \u003cp style=\"margin: 1.2pt 0in 0.0001pt 23.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.186\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.35pt;padding: 0in;height: 35.45pt;vertical-align: top;\" valign=\"top\" width=\"10.59190031152648%\"\u003e\n \u003cp style=\"margin: 1.2pt 1.3pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.177\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 116.35pt;padding: 0in;height: 16.3pt;vertical-align: top;\" valign=\"top\" width=\"16.095534787123572%\"\u003e\n \u003cp style=\"margin: 0.55pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan 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11px;\"\u003e0.871\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.35pt;padding: 0in;height: 18.7pt;vertical-align: top;\" valign=\"top\" width=\"10.59190031152648%\"\u003e\n \u003cp style=\"margin: 2.75pt 1.3pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.510\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 116.35pt;padding: 0in;height: 20.15pt;vertical-align: top;\" valign=\"top\" width=\"16.095534787123572%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eCreatinine\u0026nbsp;(umol/L)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73.4pt;padding: 0in;height: 20.15pt;vertical-align: top;\" valign=\"top\" width=\"10.176531671858775%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 11.3pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e58.58\u0026plusmn;18.75\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;padding: 0in;height: 20.15pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.85pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e58.49\u0026plusmn;19.15\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.85pt;padding: 0in;height: 20.15pt;vertical-align: top;\" valign=\"top\" width=\"9.968847352024921%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e58.49\u0026plusmn;17.09\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;padding: 0in;height: 20.15pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 15.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.716\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.1pt;padding: 0in;height: 20.15pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.788\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.25pt;padding: 0in;height: 20.15pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.986\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.5pt;padding: 0in;height: 20.15pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 24.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.704\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.65pt;padding: 0in;height: 20.15pt;vertical-align: top;\" valign=\"top\" width=\"10.072689511941848%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 23.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.931\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.35pt;padding: 0in;height: 20.15pt;vertical-align: top;\" valign=\"top\" width=\"10.59190031152648%\"\u003e\n \u003cp style=\"margin: 2.75pt 1.3pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.782\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003ctr\u003e\n \u003ctd style=\"width: 116.35pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 148.85pt;vertical-align: top;\" valign=\"top\" width=\"16.095534787123572%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eBody mass before pregnancy (kg)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eBody mass increase during pregnancy\u0026nbsp;(kg)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eBMI before pregnancy\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e(kg/m\u003csup\u003e2\u003c/sup\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003eBMI at birth\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e(kg/m\u003csup\u003e2\u003c/sup\u003e)\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 5.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 73.4pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 148.85pt;vertical-align: top;\" valign=\"top\" width=\"10.176531671858775%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 11.3pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e59.73\u0026plusmn;3.43\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 11.3pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 11.3pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e17.53\u0026plusmn;1.25\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 11.3pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 11.3pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e23.97\u0026plusmn;0.79\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 11.3pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 11.3pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e30.7\u0026plusmn;0.92\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 70.9pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 148.85pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.85pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e63.58\u0026plusmn;0.95\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.85pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.85pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e17.57\u0026plusmn;0.62\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.85pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.85pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e24.30\u0026plusmn;0.34\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.85pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.85pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e30.91\u0026plusmn;0.42\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.85pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 148.85pt;vertical-align: top;\" valign=\"top\" width=\"9.968847352024921%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e63.04\u0026plusmn;0.74\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e16.24\u0026plusmn;0.47\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e24.23\u0026plusmn;0.40\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 8.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e30.43\u0026plusmn;0.46\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 148.85pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 15.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.146\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 15.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 15.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.978\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 15.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 15.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.698\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 15.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 15.45pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.841\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.1pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 148.85pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.159\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.318\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.804\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.2pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.827\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 56.25pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 148.85pt;vertical-align: top;\" valign=\"top\" width=\"7.788161993769471%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.647\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.086\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.896\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 16.75pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.456\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 71.5pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 148.85pt;vertical-align: top;\" valign=\"top\" width=\"9.865005192107995%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 24.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.116\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 24.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 24.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.614\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 24.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 24.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.754\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 24.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 24.4pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.964\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 72.65pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 148.85pt;vertical-align: top;\" valign=\"top\" width=\"10.072689511941848%\"\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 23.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.959\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 23.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 23.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.072\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 23.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 23.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.974\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 23.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 0in 0.0001pt 23.8pt;font-size:15px;font-family: DengXian;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.463\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003ctd style=\"width: 76.35pt;border-style: none none solid;border-bottom-width: 1pt;border-bottom-color: black;padding: 0in;height: 148.85pt;vertical-align: top;\" valign=\"top\" width=\"10.59190031152648%\"\u003e\n \u003cp style=\"margin: 2.75pt 1.3pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.422\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 1.3pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 1.3pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.123\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 1.3pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 1.3pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.837\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 1.3pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e\u0026nbsp;\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003cp style=\"margin: 2.75pt 1.3pt 0.0001pt 0in;font-size:15px;font-family: DengXian;text-align: center;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003e0.472\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n \u003c/td\u003e\n \u003c/tr\u003e\n \u003c/tbody\u003e\n\u003c/table\u003e\n\u003cp style=\"margin: 0in 24.4pt 0.0001pt 11.05pt;text-align: justify;font-size:14px;font-family: DengXian;line-height: 13pt;\"\u003e\u003cspan style=\"color: rgb(0, 0, 0);\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif;\"\u003e\u003cspan style=\"font-size: 11px;\"\u003ePa\u0026nbsp;value\u0026nbsp;between\u0026nbsp;AA and\u0026nbsp;AG;\u0026nbsp;Pb\u0026nbsp;value\u0026nbsp;between\u0026nbsp;AA\u0026nbsp;and\u0026nbsp;GG;\u0026nbsp;Pc\u0026nbsp;value\u0026nbsp;between\u0026nbsp;AG\u0026nbsp;and\u0026nbsp;GG;\u0026nbsp;Pd\u0026nbsp;value\u0026nbsp;between\u0026nbsp;\u003cstrong\u003eAA\u0026nbsp;and\u0026nbsp;AG+GG\u003c/strong\u003e;\u0026nbsp;Pe\u0026nbsp;value\u0026nbsp;between\u0026nbsp;\u003cstrong\u003eGG\u0026nbsp;and AG+AA;\u0026nbsp;\u003c/strong\u003ePf\u0026nbsp;value between \u003cstrong\u003eAG and\u0026nbsp;GG+AA.\u003c/strong\u003e\u003c/span\u003e\u003c/span\u003e\u003c/span\u003e\u003c/p\u003e\n\u003cp style=\"margin: 1.8pt 24.4pt 0.0001pt 11.05pt;text-align: justify;font-size:14px;font-family: DengXian;line-height: 13pt;\"\u003e\u003cspan style=\"font-family: Verdana, Geneva, sans-serif; font-size: 11px; color: rgb(0, 0, 0);\"\u003ep \u0026lt; 0.05 is considered statistically significant. WBC, White Blood Cell; RBC, Red Blood Cell; Hb, Hemoglobin; PLT, Platelet; PT,prothrombin time; APTT, activated partial thromboplastin time; ALT, glutamic pyruvic transaminase; AST, glutamic oxaloacetictransaminase.\u003c/span\u003e\u003c/p\u003e"}],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":true,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":false,"highlight":"","institution":"","isAcceptedByJournal":true,"isAuthorSuppliedPdf":false,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":false,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"bmc-pregnancy-and-childbirth","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"prch","sideBox":"Learn more about [BMC Pregnancy and Childbirth](http://bmcpregnancychildbirth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/prch/default.aspx","title":"BMC Pregnancy and Childbirth","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true},"keywords":"polymorphism, GDM, PE, TGF-β1, TGF-β3","lastPublishedDoi":"10.21203/rs.3.rs-62203/v3","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-62203/v3","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground:\u003c/strong\u003e Gestational diabetes mellitus (GDM) is a pregnancy-specific carbohydrate intolerance Which can cause a large number of perinatal and postpartum complications. The members of Transforming growth factor-β (TGF-β) superfamily play key roles in the homeostasis of pancreatic β-cell and may involve in the development of GDM. This study aimed to explore the association between the polymorphisms of \u003cem\u003eTGF-β1\u003c/em\u003e, \u003cem\u003eTGF-β3 \u003c/em\u003eand the risk to GDM in Chinese women.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eMethods:\u003c/strong\u003e This study included 919 GDM patients (464 with preeclampsia and 455 without preeclampsia) and 1177 healthy pregnant women. TaqMan allelic discrimination real-Time PCR was used to genotype the\u003cem\u003e \u003c/em\u003eTGF-β1\u003cem\u003e \u003c/em\u003e(rs4803455) and TGF-β3 (rs2284792 and rs3917201), The Hardy-Weinberg equilibrium (HWE) was evaluated by chi-square test.\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eResults: \u003c/strong\u003eAn increased frequency of TGF-β3 rs2284792 AA and AG genotype carriers was founded in GDM patients (AA \u003cem\u003evs.\u003c/em\u003e AG+GG: χ²=6.314, \u003cem\u003eP\u003c/em\u003e=0.012, OR=1.270, 95%CI 1.054-1.530; AG \u003cem\u003evs.\u003c/em\u003e GG+AA: χ²=8.545, \u003cem\u003eP\u003c/em\u003e=0.003, OR=0.773, 95%CI 0.650-0.919). But there were no significant differences in the distribution of TGF-β1\u003cem\u003e \u003c/em\u003ers4803455 and TGF-β3\u003cem\u003e \u003c/em\u003ers3917201 between GDM and healthy women. In addition, no significant differences were found in allele and genotype frequencies among GDM patients with preeclampsia (PE).\u003c/p\u003e\u003cp\u003e\u003cstrong\u003eConclusions:\u003c/strong\u003e The AA and AG genotype of TGF-β3 rs2284792 polymorphism may be significantly associated with increased risk of GDM in Chinese population.\u003c/p\u003e","manuscriptTitle":"Polymorphisms\u0026nbsp;of\u0026nbsp;TGF-β1\u0026nbsp;and\u0026nbsp;TGF-β3\u0026nbsp;in Chinese women with Gestational Diabetes Mellitus","msid":"","msnumber":"","nonDraftVersions":[{"code":3,"date":"2020-12-08 20:30:18","doi":"10.21203/rs.3.rs-62203/v3","editorialEvents":[{"type":"communityComments","content":0},{"type":"checksComplete","content":"","date":"2020-11-28T17:14:50+00:00","index":"","fulltext":""},{"type":"decision","content":"Accept","date":"2020-11-25T00:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-pregnancy-and-childbirth","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"prch","sideBox":"Learn more about [BMC Pregnancy and Childbirth](http://bmcpregnancychildbirth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/prch/default.aspx","title":"BMC Pregnancy and Childbirth","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":2,"date":"2020-11-20 18:12:09","doi":"10.21203/rs.3.rs-62203/v2","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Minor revision","date":"2020-11-21T00:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-11-19T01:00:00+00:00","index":2,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-11-19T00:00:00+00:00","index":"","fulltext":""},{"type":"reviewerAgreed","content":"","date":"2020-11-19T00:00:00+00:00","index":1,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-11-19T00:00:00+00:00","index":1,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\nDear Authors,\nI do appreciate your efforts to clarify all issues raised in my review. I consider your response to my questions satisfactory.* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **No**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **No**\n"},{"type":"editorInvitedReview","content":"","date":"2020-11-19T00:00:00+00:00","index":2,"fulltext":"Recommendation: Accept without revision\nForm responses:\n---\n\nComments to Author:\n---\nThank you for the opportunity to review this paper.\nMy congratulations.\nKind regards,\n\n* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"editorAssigned","content":"","date":"2020-11-15T00:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-11-14T23:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-11-14T23:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-pregnancy-and-childbirth","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"prch","sideBox":"Learn more about [BMC Pregnancy and Childbirth](http://bmcpregnancychildbirth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/prch/default.aspx","title":"BMC Pregnancy and Childbirth","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}},{"code":1,"date":"2020-09-03 17:48:22","doi":"10.21203/rs.3.rs-62203/v1","editorialEvents":[{"type":"communityComments","content":0},{"type":"decision","content":"Minor revision","date":"2020-10-28T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-10-25T12:00:00+00:00","index":2,"fulltext":"Recommendation: Accept after minor essential revisions\nForm responses:\n---\n\nComments to Author:\n---\nThank you for the opportunity to review this paper. In this manuscript, Xu et al. demonstrated the analysis of polymorphisms of TGF-β1 and TGF-β3 in women with Gestational Diabetes Mellitus (with and without preeclampsia).\nThe article is well written and easy to read.\nThere are several points need to be addressed to improve this manuscript.\n\nIntroduction\nThe first paragraph well introduces the need to look for GDM risk markers.\nSince the main purpose of the study is related to TGF-β, the next paragraph should describeβthe functions of these cytokines (their involvement in many cellular processes) and their role in the development of GDM.\n\nSubjects\nPlease complete the information below or enter the absence of this information in the study restrictions.\n-Was the study group (women with GDM) uniform; were these cases treated with insulin, or were they cases treated only with diet?\n-Were there cases of gestational hypertension (GH) among the cases of GDM (and control) ?\nPlease enter when the women were recruited (before giving birth?) and when they were taken blood for testing.\n\nMethod\nPlease expand the sentence: \"DNA was extracted from peripheral venous blood\" (what method?).\n\nDiscussion\nPlease summarize the results of this study in the first paragraph.\nIn the second paragraph, please present the results from the literature in the same topic.\nIn the next paragraph, please describe the pathomechanisms and risk factors of GDM, and the role of TGF-β and polymorphisms for TGF-β.\nA brief discussion on GDM phenotypes should be presented in this section.\n\nKind regards,\n* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **Yes**\n* Declaration of competing interests: **I declare that I have no competing interests.**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"reviewerAgreed","content":"","date":"2020-10-11T12:00:00+00:00","index":2,"fulltext":""},{"type":"editorInvitedReview","content":"","date":"2020-09-30T12:00:00+00:00","index":1,"fulltext":"Recommendation: Accept after minor essential revisions\nForm responses:\n---\n\nComments to Author:\n---\nThe Authors present interesting data regarding genetics in GDM population.\nPlease, find my comments below:\n- were the polymorphisms associated with any differences in the levels of the circulating biomarker in the study group?\n- were the polymorphisms anyhow associated with maternal prepregnancy body weight/ gestational weight gain/ maternal obesity?\nThe paper should be also reviewed for minor language issues (e.g. \"in-vitro fertilisation\" should be used instead of \"artificial fecundation\", also, the Authors use the term \"weight gain of newborn\", which is unclear).* Publons Reviewer Recognition. Springer Nature can send verification of this review directly to Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal, and date of your review submission (the “Review Data”) will then be transmitted to Publons upon publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt of this review and update your profile as per your settings and their policy. If you are not registered with Publons, you will receive an email from them asking you to register in order for them to be able to recognize your review on your new profile page. Publons may use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such information. For example, Publons may verify your record as a reviewer by updating your profile published on its webservice if you have registered for such service or help editors to identify candidate reviewers. Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms: **No**\n* Declaration of competing interests: **I declare that I have no competing interests**\n* Reviewer Publication Consent. I agree for my report to be made available under an Open Access Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manuscript is accepted for publication. Any comments that I do not wish to be included in the published report have been included as confidential comments to the editor, which will not be published.: **I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)**\n* Is the study design appropriate to answer the research question (including the use of appropriate controls), and are the conclusions supported by the evidence presented?: **Yes**\n* Are the methods sufficiently described to allow the study to be repeated?: **Yes**\n* Is the use of statistics and treatment of uncertainties appropriate?: **Yes**\n* Is the presentation of the work clear?: **Yes**\n* Are the images in this manuscript (including electrophoretic gels and blots) free from apparent manipulation?: **Yes**\n"},{"type":"reviewerAgreed","content":"","date":"2020-09-14T12:00:00+00:00","index":1,"fulltext":""},{"type":"reviewersInvited","content":"","date":"2020-09-03T12:00:00+00:00","index":"","fulltext":""},{"type":"editorAssigned","content":"","date":"2020-08-20T12:00:00+00:00","index":"","fulltext":""},{"type":"checksComplete","content":"","date":"2020-08-19T12:00:00+00:00","index":"","fulltext":""},{"type":"editorInvited","content":"","date":"2020-08-19T12:00:00+00:00","index":"","fulltext":""},{"type":"submitted","content":"","date":"2020-08-18T12:00:00+00:00","index":"","fulltext":""}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"bmc-pregnancy-and-childbirth","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":false,"externalIdentity":"prch","sideBox":"Learn more about [BMC Pregnancy and Childbirth](http://bmcpregnancychildbirth.biomedcentral.com/)","snPcode":"","submissionUrl":"https://www.editorialmanager.com/prch/default.aspx","title":"BMC Pregnancy and Childbirth","twitterHandle":"@BMC_series","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"em","reportingPortfolio":"BMC Series","inReviewEnabled":true,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"79a7736a-1202-42e1-914c-98fe86e51cbd","owner":[],"postedDate":"December 8th, 2020","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"published-in-journal","subjectAreas":[{"id":1389056,"name":"Maternal \u0026 Fetal Medicine"}],"tags":[],"updatedAt":"2020-12-13T15:02:47+00:00","versionOfRecord":{"articleIdentity":"rs-62203","link":"https://doi.org/10.1186/s12884-020-03459-w","journal":{"identity":"bmc-pregnancy-and-childbirth","isVorOnly":false,"title":"BMC Pregnancy and Childbirth"},"publishedOn":"2020-12-07 15:01:14","publishedOnDateReadable":"December 7th, 2020"},"versionCreatedAt":"2020-12-08 20:30:18","video":"","vorDoi":"10.1186/s12884-020-03459-w","vorDoiUrl":"https://doi.org/10.1186/s12884-020-03459-w","workflowStages":[]},"version":"v3","identity":"rs-62203","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-62203","identity":"rs-62203","version":["v3"]},"buildId":"cBFmMYwuxLRRLfASyISRj","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}