Clinical characteristics and homology analysis of Staphylococcus aureus from would infection at a tertiary hospital in southern Zhejiang, China

Objective: Staphylococcus aureus ( S. aureus) , especially Methicillin resistant S. aureus (MRSA), has been disseminated across communities and hospitals, associated with severe infections and organ failure. In order to understand the clinical epidemiological characteristics of S. aureus stains in the first affiliated Hospital of Wenzhou Medical University in 2018, the prevalence and the drug resistance of S. aureus stains were investigated, for improving the clinical effective prevention and control of S. aureus infection. Methods A total of 105 S. aureus isolates were separated from wound infection of inpatients in the first affiliated Hospital of Wenzhou Medical University in 2018, and the department distributions and drug resistance of the isolates were analyzed. The genotyping homology analysis was conducted through the random amplified polymorphic DNA typing (RAPD-PCR) coupled with NTSYS cluster analysis. Results Among the 105 strains of S. aureus , 31 isolates were MRSA. The prevalence of MRSA among inpatients in the departments of burn, trauma, orthopedics, nephrology and neurosurgery were 35.48%, 19.35%, 9.68%, 6.45%, and 29.03%, respectively. Among the 105 strains, 35.24% strains were the hospital-acquired infections (HAI) and 64.76% strains were community-acquired infections (CAI). Random amplified polymorphic DNA genotyping of the 105 S. aureus strains showed seventeen different groups, most of which were type I, type VII, type IX, and type VII, the others were scattered. Conclusion The clinical characteristics of the 105 S. aureus between MRSA and MSSA strains differed significantly in the first affiliated Hospital of Wenzhou Medical University in 2018. In order to curb the nosocomial infection and protect the susceptible populations, it is vital for us to the monitor, prevention and control for the S. aureus infection and transmission in the nosocomial settings. The observations from the study would improve our management of disinfection and sterilization measures, and provide guidance for clinical medication.