Can Hysterosalpingo-Foam Sonography Replace Hysterosalpingography as First-Choice Tubal Patency Test? A Randomized Non-inferiority Trial

Nienke van Welie, Joukje van Rijswijk, Kim Dreyer, Machiel H A van Hooff, Jan Peter de Bruin, Harold R Verhoeve, Femke Mol, W.M. van Baal, M A F Traas, Arno M van Peperstraten, A Petra Manger, Judith Gianotten, Cornelia H. de Koning, Aafke M H Koning, Neriman Bayram, David P. van der Ham, Francisca P J M Vrouenraets, Michaela Kalafusová, Bob I G van de Laar, J. Kaijser, Arjon F Lambeek, Wouter J. Meijer, Frank J. Broekmans, Olivier Valkenburg, Lucy F van der Voet, Jeroen van Disseldorp, Marieke J. Lambers, Rachel Tros, Cornelis B. Lambalk, Jaap Stoker, Madelon van Wely, Patrick M. Bossuyt, Ben W. Mol, Velja Mijatovic
In: Obstetrical & Gynecological Survey · 2022 · vol. 77(8) , pp. 481–483 · doi:10.1097/ogx.0000000000001070 · W4288513895
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This randomized trial compared hysterosalpingo-foam sonography (HyFoSy) against hysterosalpingography (HSG) to determine if HyFoSy is a non-inferior first-choice test for tubal patency.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 · read from full text ⓘ

This randomized non-inferiority trial evaluated whether hysterosalpingo-foam sonography could replace hysterosalpingography (HSG) as a first-choice test of tubal patency in the fertility workup. Using a patient-friendlier sonography-based approach, the study compared diagnostic performance against HSG and reported that hysterosalpingo-foam sonography met non-inferiority criteria. A key caveat noted in the abstract is the clinical context that tubal pathology—including that associated with endometriosis—is a contributor to infertility, but the trial’s comparison is focused on test accuracy rather than infertility outcomes. Relevance to endometriosis: the paper cites endometriosis as one cause of tubal pathology contributing to female infertility, though the study’s main focus is comparing two tubal patency testing methods.

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Abstract

(Abstracted from Hum Reprod 2022;37:969–979) A main cause of female infertility is tubal pathology, with 11% to 30% of cases resulting from previous surgery, infections (such as sexually transmitted diseases), or endometriosis. Hysterosalpingography (HSG) is considered as the first choice for a tubal patency test during fertility workup, but the more patient-friendly hysterosalpingo-contrast sonography option has also been introduced.
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Abstract (Abstracted from Hum Reprod 2022;37:969-979) A main cause of female infertility is tubal pathology, with 11% to 30% of cases resulting from previous surgery, infections (such as sexually transmitted diseases), or endometriosis. Hysterosalpingography (HSG) is considered as the first choice for a tubal patency test during fertility workup, but the more patient-friendly hysterosalpingo-contrast sonography option has also been introduced. | Original language | English | |---|---| | Pages (from-to) | 481-483 | | Number of pages | 3 | | Journal | Obstetrical and Gynecological Survey | | Volume | 77 | | Issue number | 8 | | DOIs | | | Publication status | Published - Aug 2022 | Bibliographical note Funding Information:The project described was supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development ( HD21410 , HD27869 , HD27915 , HD27917 , HD34116 , HD34208 , HD36801 , HD40500 , HD40512 , HD40544 , HD40545 , HD40560 , HD40485 , HD53097 , HD53118 ) and the National Center for Research Resources ( UL1 RR024989 , 5UL1 RR025764 ). UN SDGs This output contributes to the following UN Sustainable Development Goals (SDGs) - SDG 3 Good Health and Well-being Fingerprint Dive into the research topics of 'Can Hysterosalpingo-Foam Sonography Replace Hysterosalpingography as First-Choice Tubal Patency Test? A Randomized Non-inferiority Trial'. Together they form a unique fingerprint.Cite this - APA - Author - BIBTEX - Harvard - Standard - RIS - Vancouver

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endometriosisinfertility

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last seen: 2026-06-04T00:00:01.174412+00:00
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