Clinical Analysis of Laparoscopic Operation Combined With Drugs Thearpy in the Treatment of Endometriosis

Objective To evaluate the effects of laparoscopic operation combined with drug therapy in the treatment of endometriosis (EMs). Methods Clinical data of 60 patients who were diagnosed as EMs from March 2011 to January 2012 in Changzhou Traditional Chinese Medicine Hospital of Jiangsu Province were analyzed prospectively. All cases were divided randomly into the treatment group (n=30, laparoscopic operation + triptorclin acetate for injection+ desogestrel and ethinylestradiol tablets) and control group (n=30, laparoscopic operation + triptorclin acetate for injection). There had no significant differences between two groups on age, cyst diameter and location, American Fertility Society (AFS) staging and so on (P<0.05). This study follows the application conforms to the ethics standards set by the human subjects committee of Changzhou Traditional Chinese Medicine Hospital, approved by the committee, grouped with the informed consent of the subjects, and signing the clinical research informed consent. The efficacy and adverse reactions were collected through follow-up by the end of 1, 3, 6, 12 months after therapy. Results There were no significant differences in symptom relief rates (82.33% vs. 86.01%) and recurrence rates (36.67% vs. 40.00%)(χ2=0.48, P=0.22; χ2=0.07, P=0.20). However in the treatment group, estradiol level, vaginal bleeding, menopausal symptoms and other adverse reactions were significantly lower than those in control group (P<0.05). By the end of 12 months after the treatment, the statistically significant difference were found in the aspects of estradiol [(41.0±23.4) pmol/L vs. (0.0±0.2) pmol/L] and CA125 levels (28.0±9.5 vs. 17.0±8.9)(t=9.60, 4.63; P<0.05). Conclusions The treatment of laparoscopic operation combined with triptorclin acetate for injection and desogestrel and ethinylestradiol tablets does not increase the recurrence rate of EMs, and the adverse reactions of which is much less. Key words: endometriosis; laparoscope; drug therapy