Endometrial Receptivity Markers In Patients With Ovulatory Polycystic Ovary Syndrome, Endometrioma And Unexplained Subfertility: A Prospective Comparative Study

Emine Demirel
In: Obstetrics Gynecology and Reproductive Sciences · 2019 · vol. 3(2) , pp. 01–04 · doi:10.31579/2578-8965/025 · W2992906489
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found no significant differences in endometrial IGFBP-1, OPN, or PGE2 levels between women with ovulatory PCOS, endometrioma, unexplained subfertility, and fertile controls, except for significantly higher PGE2 in ovulatory PCOS patients.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This prospective comparative study measured luteal-phase endometrial receptivity marker levels—IGFBP-1, osteopontin (OPN), and prostaglandin E2 (PGE2)—in endometrial washing fluid collected after ovulation from women with ovulatory PCOS (n=24), endometrioma (n=17), or unexplained subfertility (n=25), compared with fertile ovulatory controls (n=18), using ELISA assays. The reported results found statistically significant differences in PGE2 across groups, with the ovulatory PCOS group showing higher PGE2 levels than controls, while IGFBP-1 and OPN were not reported as differing significantly between groups in the abstract. The authors propose that elevated PGE2 may reflect reduced endometrial receptivity and that down-regulating PGE2 could facilitate decidualization in ovulatory PCOS, though the study itself is cross-sectional and does not assess pregnancy outcomes. Relevance to endometriosis: the paper includes an endometrioma group and compares endometrial receptivity markers across endometrioma, ovulatory PCOS, and unexplained subfertility cohorts.

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Abstract

Many molecular markers have been identified in different stages of the luteal phase those play roles in the implantation. Our aim was to compare the levels of insulin-like growth factor binding protein 1 (IGFBP-1), Osteopontin (OPN) and prostaglandin E2 (PGE2) in endometrial washing liquid between women with ovulatory polycystic ovary syndrome (PCOS), endometrioma and unexplained subfertility, compared with ovulatory women. The study groups were formed by women with ovulatory PCOS (n=24), endometrioma (n=17) and unexplained subfertility (n=25). The control group consisted of fertile women (n=18). There were no significant differences in terms of the values of IGFBP1, PGE2 and OPN among groups. There was a statistically significant difference between ovulatory PCOS group and control group in terms of PGE2 levels (p=0.002). High PGE2 might be a marker for poor endometrial receptivity. We supposed that the down-regulation of PGE2 may facilitate decidualization and improve pregnancy rate in ovulatory PCOS.

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endometrioma

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last seen: 2026-06-10T17:14:06.276822+00:00
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