A Highly Efficient and Selective Magnetic CoFe2O4@Covalent Organic Framework Nanozyme for Electrochemical Sensors
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Abstract
Metal oxide nanozymes are widely used in biosensors but face challenges such as weak selectivity, low efficiency and poor stability. In this study, CoFe 2 O 4 as the core and covalent organic frameworks (COFs) as the shell were used to prepare magnetic CoFe 2 O 4 @COFs core-shell composites conveniently by the one-pot ultrasonic method, the resultant composites were used as highly efficient and selective nanozyme for electrochemical sensors. By adjusting the COF ligand and reaction time, the COF shells with controllable pore sizes, functional groups and shell thickness were designed precisely to improve the efficiency and selectivity of CoFe 2 O 4 @COFs nanozymes. The as-synthesized core-shell CoFe 2 O 4 @COFs nanozymes were easy to be purified and separated, and the materials were analyzed by different characterization methods. The efficiency and selectivity of CoFe 2 O 4 @COFs nanozymes for catalytic performance were evaluated through glucose electrochemical sensing. The CoFe 2 O 4 @COFs electrochemical sensors exhibited excellent performance with higher sensitivity, better selectivity and stability than pure CoFe 2 O 4 . This study sheds new light on enhancing the catalytic performance of metal oxide nanozymes, which is of great scientific significance and application prospect.
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Abstract
Metal oxide nanozymes are widely used in biosensors but face challenges such as weak selectivity, low efficiency and poor stability. In this study, CoFe 2 O 4 as the core and covalent organic frameworks (COFs) as the shell were used to prepare magnetic CoFe 2 O 4 @COFs core-shell composites conveniently by the one-pot ultrasonic method, the resultant composites were used as highly efficient and selective nanozyme for electrochemical sensors. By adjusting the COF ligand and reaction time, the COF shells with controllable pore sizes, functional groups and shell thickness were designed precisely to improve the efficiency and selectivity of CoFe 2 O 4 @COFs nanozymes. The as-synthesized core-shell CoFe 2 O 4 @COFs nanozymes were easy to be purified and separated, and the materials were analyzed by different characterization methods. The efficiency and selectivity of CoFe 2 O 4 @COFs nanozymes for catalytic performance were evaluated through glucose electrochemical sensing. The CoFe 2 O 4 @COFs electrochemical sensors exhibited excellent performance with higher sensitivity, better selectivity and stability than pure CoFe 2 O 4 . This study sheds new light on enhancing the catalytic performance of metal oxide nanozymes, which is of great scientific significance and application prospect.
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Longsheng Pei, Dan Zhou, Jiamin Fang, et al.
A Highly Efficient and Selective Magnetic CoFe2O4@Covalent Organic Framework Nanozyme for Electrochemical Sensors. Authorea. 14 November 2025.
DOI: https://doi.org/10.22541/au.176310954.41414814/v1
DOI: https://doi.org/10.22541/au.176310954.41414814/v1
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