Investigating the Intradermal Irritation Test of Hydrogel: A Study on Domestic Production

This study employs the intradermal injection method to assess the skin irritation potential of domestically produced medical hydrogel. Healthy white rabbits received intradermal injections of 0.5% sodium chloride solution (control), 0.5% sodium chloride extract, and olive oil extract as test samples. Erythema and edema were observed at 24 and 72 hours post-injection, and the primary irritation index was determined. Results revealed a primary irritation index of 0 for domestically produced hydrogel, indicating no skin irritation response.