Dataset for: Characteristics of transferrin saturation and anemia-related biomarkers in patients with uterine adenomyosis

Mari Kawamata, Fumitake Ito, Nanami Tahara, Akiyo Kakibuchi, Kazuya Yabumoto, Yuko Izumi, Akihisa Katayama, Taisuke Mori
2026 · doi:10.5281/zenodo.18637559 · W7137866596
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This dataset analyzes iron metabolism markers in women with uterine adenomyosis, revealing that transferrin saturation and ferritin levels improve iron deficiency detection compared to ferritin alone due to inflammation-related masking.

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This retrospective study analyzed iron metabolism markers in non-menopausal women aged 30 to 55 years presenting with uterine adenomyosis. The researchers compared the prevalence of anemia and various definitions of iron deficiency, including functional iron deficiency characterized by low transferrin saturation despite normal ferritin levels. Results indicated that iron deficiency was more frequent than anemia, and combining ferritin with transferrin saturation significantly improved detection rates compared to using ferritin alone. The weak correlation between hemoglobin and transferrin saturation in this group suggests inflammation may mask true iron status when relying solely on ferritin. This paper is centrally about adenomyosis — specifically evaluating diagnostic biomarkers for iron deficiency within a cohort of patients diagnosed with this condition.

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Abstract

This dataset contains the anonymized clinical data analyzed in the study titled "Characteristics of transferrin saturation and anemia-related biomarkers in patients with uterine adenomyosis". Abstract:Background: Ferritin may be elevated as an acute-phase reactant in inflammatory conditions, potentially masking iron deficiency. We aimed to evaluate the frequency of iron deficiency and the diagnostic significance of transferrin saturation (TSAT) in women with uterine adenomyosis. Methods: This retrospective study included non-menopausal women aged 30–55 years who had iron metabolism markers measured at first visit. Anemia was defined as hemoglobin (Hb) <11 g/dL. Iron deficiency was defined using three criteria: ferritin-only (serum ferritin <20 ng/mL), TSAT-only (TSAT <20%), and a combined criterion (ferritin <20 ng/mL and/or TSAT <20%). Functional iron deficiency was defined as TSAT <20%, with ferritin ≥20 ng/mL. We compared the frequencies of anemia and iron deficiency across groups and evaluated correlations between Hb and TSAT. Results: Iron deficiency was more common than anemia in all patient groups. In the adenomyosis group, the frequency of iron deficiency based on the combined criterion was significantly higher than that diagnosed using ferritin alone. The correlation between Hb and log(TSAT) was weak in the adenomyosis group but strong in the myoma and no uterine structural abnormality groups. Conclusions: Measuring TSAT and ferritin levels enhances the detection of iron deficiency in women with adenomyosis and may help identify functional iron deficiency when ferritin interpretability is limited by inflammation.
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Abstract

Background: Ferritin may be elevated as an acute-phase reactant in inflammatory conditions, potentially masking iron deficiency. We aimed to evaluate the frequency of iron deficiency and the diagnostic significance of transferrin saturation (TSAT) in women with uterine adenomyosis.

Methods

This retrospective study included non-menopausal women aged 30–55 years who had iron metabolism markers measured at first visit. Anemia was defined as hemoglobin (Hb) <11 g/dL. Iron deficiency was defined using three criteria: ferritin-only (serum ferritin <20 ng/mL), TSAT-only (TSAT <20%), and a combined criterion (ferritin <20 ng/mL and/or TSAT <20%). Functional iron deficiency was defined as TSAT <20%, with ferritin ≥20 ng/mL. We compared the frequencies of anemia and iron deficiency across groups and evaluated correlations between Hb and TSAT.

Results

Iron deficiency was more common than anemia in all patient groups. In the adenomyosis group, the frequency of iron deficiency based on the combined criterion was significantly higher than that diagnosed using ferritin alone. The correlation between Hb and log(TSAT) was weak in the adenomyosis group but strong in the myoma and no uterine structural abnormality groups.

Conclusions

Measuring TSAT and ferritin levels enhances the detection of iron deficiency in women with adenomyosis and may help identify functional iron deficiency when ferritin interpretability is limited by inflammation. Files Adenomyosis_Iron_Deficiency_Dataset.csv Files (11.5 kB) | Name | Size | Download all | |---|---|---| | md5:99531ed0b211e7ff5f34c1923cf5364c | 11.5 kB | Preview Download |

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adenomyosis

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last seen: 2026-06-04T00:00:01.174412+00:00
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