ДІАГНОСТИКА ЕНДОМЕТРІОЗУ МЕТОДАМИ ДИФУЗНОЇ ІНТРОСКОПІЇ ГІСТОЛОГІЧНИХ ЗРІЗІВ БІОПСІЇ ЕНДОМЕТРІЮ

Abstract. Introduction. The method to obtain high-quality results in tissues and biological fluids with different densities has been initiated taking into account high accuracy of the results by polarimetry in transparent media. The aim of the study. To evaluate the effectiveness of differential diagnosis of endometriosis using diffuse Muller-matrix endoscopy of histological sections of endometrial biopsy. Material and methods. This article contains the following results of endometriosis diagnosis of endometriosis histological sections of endometrial biopsy using the methods of diffuse Muller-matrix endoscopy.Two groups of samples were studied: biopsy of «healthy» uterine tissue obtained during diagnostic hysteroscopy - control group 1 - 68 samples; ● biopsy of endometrioid tissue with endometriosis - research group 2 - 59 samples. Research results. A high level of parameters of the diagnostic power of detecting endometriosis was revealed by using a set of statistical markers of the method of polarization-phase Müller-matrix introscopy of linear birefringence thesiograms of native histological sections of endometrial biopsy very good diagnostic accuracy using statistical markers of the 1st and 2nd orders (-92,1% - 93,7%); SM1;SM2; excellent diagnostic accuracy using statistical markers of the 3rd and 4th orders (-97,1% - 98,4%); SM3;SM4 Diagnostic markers of this pathological process are a statistically significant increase (pi=1;2;3;4<0,05) in the value of the average and variance of theziograms of the coordinate distributions of the random values  of the fluctuations of the circular birefringence. The values  of asymmetry and kurtosis, on the contrary, decrease (pi=1;2;3;4<0,05). Conclusions. The application of the method of polarization-phase Müller-matrix introscopy of linear birefringence of fibrillar protein nets revealed an excellent level of diagnosis of endometriosis