06 - THE EFFECT OF LATERALITY OF ENDOMETRIOMA IN IVF/ICSI CYCLES

The effect of laterality of endometrioma in IVF/ICSI cycles Nafiye Yu0131lmaz, M. Ufuk Ceran, E. Nil Ugurlu, H. Cavidan Gulerman, Yaprak UstunProblem StatementEndometriosis, the most common gynecological disorder, is a challenging disease observed in 20%- 40% of subfertile women. Endometriomas affect 17-44% of women with endometriosis.Because endometrioma has detrimental effects on fertility. many of these women need Assisted Reproductive Technology (ART) to conceive. In this study, we aimed to investigate the effects of endometrioma presence and laterality over In Vitro Fertilization (IVF) and Intracytoplasmic Sperm Injection (ICSI) outcomes.MethodsThe study was designed retrospectively. A total of 159 women enrolled in IVF / ICSI cycles between March 2015-March 2018, were included. Patients were divided into two groups as Endometrioma group (n: 73) and control group (n:86). In Endometrioma group, subgroup analysis was performed according to laterality. Demographic characters, clinical and laboratory parameters were recorded. SPSS was used for analysisResultsThere were no significant differences between groups with respect to age, BMI, stimulation protocols. In endometrioma group, although basal FSH levels was higher than control group, it was within normal limits, while estradiol levels was lower ( p<0.001, p 0.042, respectively). Antral Follicle count (AFC), dominant follicle number, total oocyte count, MII oocyte numbers were found to be significantly lower, whereas numbers of embryos achieved, clinical pregnancy rates were found to be similar. In endometrioma group, there were 4 patients with no dominant folicle development and 8 total fertilization failures were observed. With respect to laterality, there were no statistically significant differences in terms of Antimullerian Hormone (AMH) levels, oocyte and embryo quality, the numbers of embryos achieved, pregnancy rates between two groups When compared according to previous history of surgery (26 patients), AFC and AMH levels were found to be lower in patients who underwent surgery, while there was no significant difference regarding oocyte numbers, embryo quality and pregnancy rates.ConclusionThis study shows that presence of endometrioma negatively effects on fertility parameters like FSH levels, AFC and MII oocyte numbers, albeit no significant effect over embryo quality and pregnancy rates whereas laterality of endometrioma doesn’t have any influence over any fertility parameters and pregnancy rates.