Effects of Guizhi Fuling Capsule on the Expression of MCP-1 and ICAM-1 mRNA of Ectopic Endometrium in Rats with Endometriotics

Objective:To study the effects of Guizhi Fuling Capsule on expression of monocyte chemoattractant protein-1(MCP-1) and inter-cellular adhesion molecule-1(ICAM-1) mRNA of ectopic endometrium in rats with endometriosis.Method:Endometriosis model of rat was created by self-transplant,and then administrated with Guizhi Fuling Capsule(0.256,1.024 g·kg-1) orally for 28 days.Expression and distribution of MCP-1 and ICAM-1 in ectopic endometrium were observed by immunohistochemistry.The mRNA expression of MCP-1,ICAM-1 were evaluated with RT-PCR.Result:The expression and distribution of MCP-1 and ICAM-1 were significantly decreased after treatment with Guizhi Fuling Capsule.Both dose showed similar effect without significant difference.Conclution:The distribution of MCP-1 and ICAM-1 in ectopic endometrium of endometriosis can be modified by Guizhi Fuling Capsule and the mRNA expression was decreased.