Association between myopia and peripapillary hyperreflective ovoid mass-like structures in children

ABSTRACT Purpose To investigate the characteristics of children with peripapillary hyperreflective ovoid mass-like structures (PHOMS) and evaluate the risk factors associated with PHOMS. Methods This study included 132 eyes of 66 children with PHOMS and 92 eyes of 46 children without PHOMS (controls) who were assessed by disc enhanced depth image spectral-domain optical coherence tomography (OCT). Univariable and multivariable logistic analyses were performed to evaluate risk factors associated with the presence of PHOMS. Results Among the 66 children with PHOMS, 53 patients (80.3%) had bilateral and 13 patients (19.7%) had unilateral PHOMS. The mean age of the PHOMS group was 11.7 ± 2.6 years and 11.4 ± 3.1 years in the control group. Mean spherical equivalent (SE) by cycloplegic refraction was −3.13 ± 1.87 diopters (D) in the PHOMS group and −0.95 ± 2.65 D in the control group. Mean astigmatism was 0.67 ± 0.89 D and 0.88 ± 1.02 D in the PHOMS group and the control group, respectively. Mean disc size was 1735 ± 153 μm in the PHOMS group and 1741 ± 190 μm in the control group. All eyes in PHOMS group had myopia of −0.50 D or less, except for an eye with +1.00 D. According to the univariable (odds ratio [OR] 1.59, P < 0.001) and multivariable (OR 2.00, P < 0.001) logistic regression analyses, SE decreased by 1 D was significantly associated with PHOMS. Conclusions PHOMS is associated with myopic shift in children. Optic disc tilt may be a mediator between myopia and PHOMS.