Tapping into symbiosis to advance human microbiome research

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Abstract

In human microbiome research, the term commensal is often used to describe organisms that benefit their hosts. In ecology, where the term originates, a commensal organism has no impact on its host, whereas a mutualist organism benefits its host. While others have recognized this discrepancy in terminology use, old habits are hard to break, and the human microbiome community has continued in this vein. This is our call to action for the human microbiome community to use more precise terminology that appropriately reflects the impact that these microbes have on their hosts. We should use the terms commensal and mutualist when we know the effect on the host, and symbiont when we do not. By using the same terminology as ecologists, we will be able to make use of and contribute to the vast research in the field of symbiosis.
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This is a Preprint and has not been peer reviewed. This is version 2 of this Preprint. You must log in to post a comment. There are no comments or no comments have been made public for this article. This is a Preprint and has not been peer reviewed. This is version 2 of this Preprint. Add a Comment You must log in to post a comment. Comments There are no comments or no comments have been made public for this article. In human microbiome research, the term commensal is often used to describe organisms that benefit their hosts. In ecology, in host-microbe symbiosis, a commensal organism has no impact on its host, whereas a mutualist organism benefits its host. While others have recognized this discrepancy in terminology use, old habits are hard to break, and the human microbiome community has continued in this vein. This is our call to action for the human microbiome community to use more precise terminology that appropriately reflects the impact that these microbes have on their hosts. We should use the terms commensal and mutualist when we know the effect on the host, and symbiont when we do not. By using the same terminology as ecologists, we will be able to make use of and contribute to the vast research in the field of symbiosis. https://doi.org/10.32942/X2FH3Z Bacteriology, Ecology and Evolutionary Biology, Environmental Microbiology and Microbial Ecology Life Sciences, Life Sciences, Other Microbiology, Pathogenic Microbiology commensal, mutualist, parasite, pathogen, microbe-host interactions, symbiont Published: 2026-02-25 15:14 Last Updated: 2026-05-02 15:00 CC-BY Attribution-NonCommercial 4.0 International Conflict of interest statement: None Data and Code Availability Statement: Not applicable Language: English

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