Peliosis hepatis. Report of nine cases

T Karasawa, Tsutomu Karasawa, Toshio Shikata, T Shikata, R D Smith, Roger Smith
Acta pathologica japonica · 1979 · vol. 29(3) , pp. 457–469 · doi:10.1111/j.1440-1827.1979.tb00201.x · PMID:582233 · W2038085372
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This report describes nine cases of peliosis hepatis associated with androgen use or underlying neoplasms, suggesting that hepatic sinusoid angiopathy and passive congestion contribute to the condition's pathogenesis.

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Abstract

Nine cases of peliosis hepatis are reported: five of these were associated with the administration of androgen or anabolic androgenic steroids and a sixth with large doses of medroxy-progesterone acetate. In five instances, neoplasm was present as an underlying disease. Antemortem evidence of liver disease was detected in six of seven cases but was not severe and had not contributed to death. The pathogenesis of blood-filled cystic cavities is discussed and the literature reviewed. Angiopathy of hepatic sinusoids in patients with wasting diseases or in those receiving androgens in coexistence with passive congestion of the liver appear to be factors in the pathogenesis of pleiosis hepatis.

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MeSH descriptors

Liver Diseases Adenocarcinoma Adenocarcinoma Adult Aged Arthritis, Rheumatoid Arthritis, Rheumatoid Breast Neoplasms Breast Neoplasms Cysts Cysts Female Femoral Neck Fractures Femoral Neck Fractures Heart Failure Heart Failure Hodgkin Disease Hodgkin Disease Humans Kidney Neoplasms

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References (21)

SciLite annotations

chemicals 4
steroid progesterone acetate androgen

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