Anesthetic Challenges of Caring for an Adult with Moebius Syndrome: A Case Report

Anesthetic Challenges of Caring for an Adult with Moebius Syndrome: A Case Report | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Case Report Anesthetic Challenges of Caring for an Adult with Moebius Syndrome: A Case Report Geetasravya Vegunta, Giovanna Patafio DO, Swata Gade, Kwame Awuku, and 2 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-4697518/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Background Moebius syndrome is a rare congenital disorder with facial nerve palsies and craniofacial malformations, increasing the risk of a difficult airway during anesthesia. We report a difficult airway in an adult with Moebius syndrome during an elective procedure, which is unique as most reports of Moebius syndrome are in children. Case Presentation Our patient was a 30-year old male diagnosed with Moebius syndrome at birth, and presented with craniofacial and orthopedic malformations, intellectual disability, and facial nerve palsies. Although our patient had prior successful intubations, their airway exam deteriorated from a Mallampati Class II to IV after many surgeries. After fiberoptic intubation with nebulized lidocaine to maintain spontaneous ventilation failed, an attempt with dexmedetomidine and video laryngoscopy was successful. Conclusion Our case demonstrates the necessity of preparing for a difficult airway and strategies for airway management in an adult with Moebius Syndrome. case report Moebius syndrome difficult airway Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-4697518","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Case Report","associatedPublications":[],"authors":[{"id":325613294,"identity":"2ff3fdd6-871d-4327-a5d1-a3980daa94ab","order_by":0,"name":"Geetasravya Vegunta","email":"","orcid":"","institution":"Rutgers New Jersey Medical School","correspondingAuthor":false,"prefix":"","firstName":"Geetasravya","middleName":"","lastName":"Vegunta","suffix":""},{"id":325613296,"identity":"963d1222-d0b9-4e0e-a42a-286ac5efdcdc","order_by":1,"name":"Giovanna Patafio DO","email":"","orcid":"","institution":"Rutgers New Jersey Medical 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airway","lastPublishedDoi":"10.21203/rs.3.rs-4697518/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-4697518/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003e\u003cstrong\u003eBackground \u003c/strong\u003eMoebius syndrome is a rare congenital disorder with facial nerve palsies and craniofacial malformations, increasing the risk of a difficult airway during anesthesia. We report a difficult airway in an adult with Moebius syndrome during an elective procedure, which is unique as most reports of Moebius syndrome are in children.\u0026nbsp;\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eCase Presentation\u003c/strong\u003e Our patient was a 30-year old male diagnosed with Moebius syndrome at birth, and presented with craniofacial and orthopedic malformations, intellectual disability, and facial nerve palsies. Although our patient had prior successful intubations, their airway exam deteriorated from a Mallampati Class II to IV after many surgeries. 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