Laboratory evaluation of vasoreactivity; asymmetric dymethylarginine, nitric oxide, fibrinogen and high sensitive C-reactive protein in patients with polycystic ovary syndrome

Abstract Background-Aim We aimed to compare of fibrinogen, high sensitivie C reactive protein (hsCRP), asymmetric dymethylarginine (ADMA) and nitric oxide (NO) levels as laboratory parameters of vasoreactivity in patients with PCOS. Material and Methods Thirty patients with PCOS and 30 women with normal ovulating cycles were enrolled. Serum levels of NO, ADMA, fibrinogen, FSH, LH and hsCRP were assessed and compared with the control group. Results The mean ADMA, fibrinogen and hsCRP levels were significantly higher, and NO concentrations were lower in the patient group. A significant positive correlation was observed between ADMA and NO levels, ADMA and fibrinogen (r=0.838, p<0.001), and ADMA and hsCRP concentrations. Fibrinogen and NO, and NO and hsCRP levels were significantly negatively correlated in the patient group. In the control group, there was a positive correlation between fibrinogen and age, and there was a negative correlation between NO and FSH. Conclusion The present study determined positive relation between ADMA levels and vasoreactive parameters of patients with PCOS. Women with PCOS have elevated levels of ADMA, fibrinogen and decreased NO that make them candidates for cardiovascular disease. Further studies are required to establish the association of ADMA with vascular reactivity.