A Case-Control Study On Dietary Nutrition and Dietary Habits of Kazakh Esophageal Cancer Patients in Xinjiang

Objective: To explore the causes of esophageal cancer (ESCC) and provide a theoretical basis for prevention and treatment of ESCC by analyzing dietary nutrients intake and other blood indicators of Kazakh patients with ESCC. Methods: 198 ESCC cases and 200 controls were recruited in Xinjiang. The food frequency questionnaire was used to investigate the dietary nutrients intake. After collecting blood samples, the automated chemiluminescence immunoassay analyzer was applied to measure serum FA level and serum vitamin B12 level. The enzyme-linked immunosorbent assay was used to observe the serum DNMT1 level. Results: The cholesterol intake of ESCC group was higher than that of the control group while the intakes of protein, thiamin, riboflavin, FA, vitamin A, B6, C and E were lower than the control group. Levels of serum FA and serum vitamin B12 in ESCC group were lower, while the serum DNMT1 level was higher. Conclusion: Lacking fresh vegetables, low educational level, low income, alcoholism, eating solid and dry food and smoked meat, dieting irregularly, low serum FA level, high serum DNMT1 level were risky factors of ESCC for Kazakhs. The occurrence of ESCC reduced with the increase of serum FA but increased when serum DNMT1 increased.