Pt nanoshell with ultra-high NIR-Ⅱ photothermal conversion efficiency mediates multifunctional neuromodulation for cardiac protection

Pt nanoshell with ultra-high NIR-Ⅱ photothermal conversion efficiency mediates multifunctional neuromodulation for cardiac protection | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Article Pt nanoshell with ultra-high NIR-Ⅱ photothermal conversion efficiency mediates multifunctional neuromodulation for cardiac protection Lei Fu, Chenlu Wang, Liping Zhou, Chengzhe Liu, Jiaming Qiao, and 10 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-3985327/v1 This work is licensed under a CC BY 4.0 License Status: Published Journal Publication published 28 Jul, 2024 Read the published version in Nature Communications → Version 1 posted You are reading this latest preprint version Abstract The autonomic nervous system plays a pivotal role in the pathophysiology of cardiovascular diseases. Regulating it is essential for preventing and treating acute ventricular arrhythmias (VAs). Photothermal neuromodulation is a nonimplanted technique, but the response temperature ranges of transient receptor potential vanilloid 1 (TRPV1) and TWIK-elated K+ Channel 1 (TREK1) exhibit differences while being closely aligned, and the acute nature of VAs require that it must be rapid and precise. However, the low photothermal conversion efficiency (PCE) still poses limitations on achieving rapid and precise treatment. Here, we achieved nearly perfect blackbody absorption and one of the highest PCE in the second near infrared (NIR-II) window (73.7% at 1064 nm) via a Pt nanoparticle shell (PtNP-shell). By precisely manipulating the photothermal effect, we successfully achieved rapid and precise multifunctional neuromodulation encompassing neural activation (41.0–42.9 oC) and inhibition (45.0–46.9 oC). The NIR-II photothermal modulation additionally achieved bi-directional reversible autonomic modulation and conferred protection against acute VAs associated with myocardial ischemia and reperfusion injury in interventional therapy. Physical sciences/Nanoscience and technology/Nanoscale materials/Nanoparticles Biological sciences/Biotechnology/Biomaterials Full Text Additional Declarations There is NO Competing Interest. Supplementary Files supplementaryinformation.docx Cite Share Download PDF Status: Published Journal Publication published 28 Jul, 2024 Read the published version in Nature Communications → Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-3985327","acceptedTermsAndConditions":true,"allowDirectSubmit":false,"archivedVersions":[],"articleType":"Article","associatedPublications":[],"authors":[{"id":275793760,"identity":"9019c0dc-9733-4f86-bced-46eafc15efbf","order_by":0,"name":"Lei 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