Gold(I)-Catalyzed Stereoselective Cyclization of 1,3-Enyne Aldehydes by 1,3-Acyloxy Migration/Nazarov/Aldol Cascade
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Gold(I)-catalyzed domino reactions of 1,3-enyne aldehydes with propargylic acetates create stereodefined bicyclo[3.3.0]octenones through migration, Nazarov cyclization, and aldol addition.
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Abstract
Stereoselective synthesis of bicyclo[3.3.0]octenones from chiral 1,3 enyne aldehydes bearing propargylic acetates is described. The method is based on a Au(I)-catalyzed domino sequence with concomitant transfer of chirality involving 1,3-acyloxy migration followed by Nazarov cyclization and an unprecedented aldol addition. The method furnishes densely functionalized bicyclic structures in high yields, up to 97% ee, and good diastereoselectivity.
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- europepmc
- last seen: 2026-05-19T01:45:01.086888+00:00