Research Progress of Mifepristone in Drug-resistance Ovarian Cancer

Mifepristone(RU486)is a kind of antagonist acting on progesterone receptor level,which aslso function as anti-glucocorticoid.Mifepristone are mainly used to terminate the pregnancy,emergency contraception and induced abortion in clinical.In recent years,the use of its anti-progesterone activity in the treatment of uterine fibroids,endometriosis,ectopic pregnancy also succeed.Recent studies have found that mifepristone can inhere the growth of ovarian cancer epithelial cells,and has certain curative effect for drug-resistant ovarian cancer.Here is to make a review on the mechanism,in vivo and ex vivo research progress of mifepristone in the treatment of drug-resistant ovarian cancer.