Role of Adenogenesis Factors in the Pathogenesis of Endometriosis

Endometriosis is a pathological condition characterized by the presence of the endometrial tissue, including epithelial and stromal components, outside the uterine cavity. It affects nearby 10% of women of reproductive age and is responsible for infertility, chronic pain and the weakening of the quality of life. Various pathogenetic mechanisms have been suggested, such as retrograde menstruation, coelomic metaplasia, embryological defects, stem cell involvement, and alterations in epigenetic regulation. However, the essential pathogenesis of endometriosis remains insufficiently comprehended. Individuating the exact mechanism of the growth and development of endometriosis is essential for valuable cure. This review reports the foremost pathogenetic theories of endometriosis based on recent investigations with a major emphasis on the potential role of uterine adenogenesis factors.