Enigma of Pyramidal Neurons:Chirality-Centric View on Biological Evolution. Congruence to Molecular, Cellular, Physiological, Cognitive and Psychological Function

The mechanism of brain information processing unfolds within spatial and temporal domains inherently linked to the concept of symmetry. Biological evolution, beginning with the prevalent molecular chirality, results in the handedness of cognitive and psychological functions (the phenomena known as biochirality). The key element in the chain of chirality transfer from the downstream to upstream processes is the pyramidal neuron (PyrN) morphology-function paradigm (archetype). The most apparent landmark of PyrN is the geometry of the cell soma. However, “why/how PyrN soma gains the shape of quasi-tetrahedral symmetry” has never been explicitly articulated. Resolving the above inquiry is only possible based on the broad-view assumption that encoding 3D-space requires specific 3D-geometry of the neuronal detector and corresponding network. Accordingly, our hypothesis states that if the primary function of PyrNs, at the organism level, is sensory space perception, then the pyramidal shape of soma is the best evolutionary-selected geometry to support sensory-motor coupling.