Treadmill exercise alters ecstasy- induced long- term potentiation disruption in the hippocampus of male rats.

3, 4-methylenedioxymethamphetamine (MDMA) or ecstasy is a derivative of amphetamine that leads to long term potentiation (LTP) disruption in the hippocampal dentate gyrus (DG). Exercise has been accepted as a treatment for the improvement of neurodegenerative disease. Herein, the effects of exercise on the MDMA- induced neurotoxicity were assessed. Male Wistar rats received intraperitoneal injection of MDMA (10 mg/kg) and exercised for one month on a treadmill (Simultaneously or asynchronously with MDMA). LTP and expression of BDNF were assessed using electrophysiology and western blotting methods, respectively. MDMA attenuated the field excitatory post-synaptic potential (fEPSP) slope in comparison with the control group, whereas treadmill exercise increased this parameter when compared to MDMA group. Furthermore, BDNF expression significantly decreased in MDMA group and treadmill exercise could increase that. In conclusion, results of this study suggest that synchronous exercise is able to improve MDMA-induced LTP changes through increase of BDNF expression in the hippocampus of rats. Similar content being viewed by others Change history 25 September 2017 In the original publication of the article, author name Masoumeh Asadbegi was incorrectly written as Masoumeh Asadbeigi. The authors regret the oversight.

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The data used in this paper was extracted from M.Sc. thesis of Azam Sajadi and supported by Hamadan University of Medical Sciences No.9410015475. Author information Authors and Affiliations Corresponding author Ethics declarations Conflict of interest statement None of the authors of this paper have a financial interest to report. Additional information An erratum to this article is available at https://doi.org/10.1007/s11011-017-0114-1. Rights and permissions About this article Cite this article Sajadi, A., Amiri, I., Gharebaghi, A. et al. Treadmill exercise alters ecstasy- induced long- term potentiation disruption in the hippocampus of male rats. Metab Brain Dis 32, 1603–1607 (2017). https://doi.org/10.1007/s11011-017-0046-9 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s11011-017-0046-9