Effects of PCB31 on the Related Genes of Endomtriosis
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Abstract
The molecular mechanism of polychlorinated biphenyls(PCB)on endometriosis was still unknown.This study aimed to assess the effects of PCB31on endometriotic stromal cells derived from primary culture.The results showed that lower concentrations of PCB31 did not affect the proliferation while higher concentration inhibited the proliferation.The mRNA expression of the matrix metalloproteinase(MMP2)gene and the cyclooxygenase-2(COX-2)gene was both upregulated after PCB31exposure.PCB31induced the expression of interleukin both at the mRNA and protein level.In all,PCB31could affect endometriosis through up-regulation of related genes.
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- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
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