Woven EndoBridge Device for Ruptured vs. Unruptured Aneurysms: Insights from the WorldWideWEB Study

Woven EndoBridge Device for Ruptured vs. Unruptured Aneurysms: Insights from the WorldWideWEB Study | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Woven EndoBridge Device for Ruptured vs. Unruptured Aneurysms: Insights from the WorldWideWEB Study Franja Dugar, Muhammed Amir Essibayi, Hamza Adel Salim, Basel Musmar, and 84 more This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-8939206/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Purpose Although the Woven EndoBridge (WEB) device is increasingly used for the treatment of wide-neck intracranial aneurysms, including in the acute rupture setting, comparative evidence assessing the impact of rupture status remains limited. This study compared angiographic, safety, and clinical outcomes between ruptured and unruptured intracranial aneurysms treated with WEB. Methods We conducted a retrospective analysis of prospectively collected data from the multicenter cohort registry WorldWideWEB, including consecutive adult patients with intracranial aneurysms treated with the WEB. Patients were stratified into groups of ruptured and unruptured aneurysms. Propensity score matching was used to balance baseline characteristics between both groups. Retreatment rate was the primary outcome. Secondary outcomes included mRS, safety events (thromboembolic complications) and angiographic outcomes (periprocedurally and last follow-up). Results Among 1,220 patients, 342 (28.0%) presented with ruptured aneurysms. There was no significant difference in the rate of thromboembolic complications between groups (11.8% vs 5.9%, p = 0.056). At follow-up, adequate occlusion was lower (82.2% vs 93.3%, p 0.9) and retreatment rates (11.8% vs 7.1%, p = 0.14) did not differ between groups after matching. Conclusion Ruptured aneurysms demonstrated expected inferior follow-up functional and angiographic outcomes when compared with unruptured aneurysms, but no difference in retreatment rate and procedural safety. These findings support WEB as a safe and effective treatment option for appropriately selected ruptured intracranial aneurysms in routine clinical practice. Intracranial aneurysm Ruptured intracranial aneurysm Woven EndoBridge device Endovascular treatment Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. Our growing team is made up of researchers and industry professionals working together to solve the most critical problems facing scientific publishing. Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-8939206","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":607261435,"identity":"8b61d23c-e376-4af3-ba2d-e23f98b18158","order_by":0,"name":"Franja Dugar","email":"","orcid":"","institution":"Triemli Hospital","correspondingAuthor":false,"prefix":"","firstName":"Franja","middleName":"","lastName":"Dugar","suffix":""},{"id":607261436,"identity":"3f5e1644-085c-4675-8a6e-55b027432a17","order_by":1,"name":"Muhammed Amir Essibayi","email":"","orcid":"","institution":"Montefiore Medical Center","correspondingAuthor":false,"prefix":"","firstName":"Muhammed","middleName":"Amir","lastName":"Essibayi","suffix":""},{"id":607261437,"identity":"8dfcd12a-4852-4dae-85cf-f1409908e25e","order_by":2,"name":"Hamza Adel Salim","email":"","orcid":"","institution":"The University of Texas MD Anderson Cancer Center","correspondingAuthor":false,"prefix":"","firstName":"Hamza","middleName":"Adel","lastName":"Salim","suffix":""},{"id":607261438,"identity":"b02a8c82-41ab-4b52-a79b-a4bd27f8c54a","order_by":3,"name":"Basel Musmar","email":"","orcid":"","institution":"Louisiana State University Health Sciences Center Shreveport","correspondingAuthor":false,"prefix":"","firstName":"Basel","middleName":"","lastName":"Musmar","suffix":""},{"id":607261439,"identity":"b9841e91-b5f9-4d3b-b960-4bd6752b7a77","order_by":4,"name":"Nimer Adeeb","email":"","orcid":"","institution":"Louisiana State University Health Sciences Center Shreveport","correspondingAuthor":false,"prefix":"","firstName":"Nimer","middleName":"","lastName":"Adeeb","suffix":""},{"id":607261440,"identity":"b53e9506-77ba-4dbd-8eac-27f0d400012a","order_by":5,"name":"Mahmoud Dibas","email":"","orcid":"","institution":"Louisiana State University Health Sciences Center Shreveport","correspondingAuthor":false,"prefix":"","firstName":"Mahmoud","middleName":"","lastName":"Dibas","suffix":""},{"id":607261441,"identity":"220e2812-34bf-466b-8a44-820a2062294d","order_by":6,"name":"Yan-Lin Li","email":"","orcid":"","institution":"University of Oxford","correspondingAuthor":false,"prefix":"","firstName":"Yan-Lin","middleName":"","lastName":"Li","suffix":""},{"id":607261442,"identity":"d9a88b91-6b23-41e7-9ad5-6149d8c6644a","order_by":7,"name":"Oktay Algin","email":"","orcid":"","institution":"Ankara University","correspondingAuthor":false,"prefix":"","firstName":"Oktay","middleName":"","lastName":"Algin","suffix":""},{"id":607261443,"identity":"c75f4376-6084-4da2-aebb-dcaf828b33bb","order_by":8,"name":"Sherief Ghozy","email":"","orcid":"","institution":"Mayo Clinic","correspondingAuthor":false,"prefix":"","firstName":"Sherief","middleName":"","lastName":"Ghozy","suffix":""},{"id":607261444,"identity":"1a9ca836-ddb1-4aff-802b-81d3f6db6114","order_by":9,"name":"Sovann V. 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This study compared angiographic, safety, and clinical outcomes between ruptured and unruptured intracranial aneurysms treated with WEB.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eMethods\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eWe conducted a retrospective analysis of prospectively collected data from the multicenter cohort registry WorldWideWEB, including consecutive adult patients with intracranial aneurysms treated with the WEB. Patients were stratified into groups of ruptured and unruptured aneurysms. Propensity score matching was used to balance baseline characteristics between both groups. Retreatment rate was the primary outcome. Secondary outcomes included mRS, safety events (thromboembolic complications) and angiographic outcomes (periprocedurally and last follow-up).\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eResults\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eAmong 1,220 patients, 342 (28.0%) presented with ruptured aneurysms. There was no significant difference in the rate of thromboembolic complications between groups (11.8% vs 5.9%, \u003cem\u003ep \u003c/em\u003e= 0.056). At follow-up, adequate occlusion was lower (82.2% vs 93.3%, \u003cem\u003ep \u003c/em\u003e\u0026lt; 0.002) and functional outcomes were worse (mRS ≥2 in 34.1% vs 21.9%, \u003cem\u003ep \u003c/em\u003e= 0.012) among patients with ruptured aneurysms. Periprocedural adequate occlusion (53.3% vs 53.8%, p\u0026gt;0.9) and retreatment rates (11.8% vs 7.1%, p = 0.14) did not differ between groups after matching.\u003c/p\u003e\n\u003cp\u003e\u003cstrong\u003eConclusion\u003c/strong\u003e\u003c/p\u003e\n\u003cp\u003eRuptured aneurysms demonstrated expected inferior follow-up functional and angiographic outcomes when compared with unruptured aneurysms, but no difference in retreatment rate and procedural safety. These findings support WEB as a safe and effective treatment option for appropriately selected ruptured intracranial aneurysms in routine clinical practice.\u003c/p\u003e","manuscriptTitle":"Woven EndoBridge Device for Ruptured vs. Unruptured Aneurysms: Insights from the WorldWideWEB Study","msid":"","msnumber":"","nonDraftVersions":[{"code":1,"date":"2026-03-18 16:59:15","doi":"10.21203/rs.3.rs-8939206/v1","editorialEvents":[{"type":"communityComments","content":0}],"status":"published","journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true}}],"origin":"","ownerIdentity":"8f20a4cb-5048-4033-9435-37c0ec8ddd71","owner":[],"postedDate":"March 18th, 2026","published":true,"recentEditorialEvents":[],"rejectedJournal":[],"revision":"","amendment":"","status":"posted","subjectAreas":[],"tags":[],"updatedAt":"2026-04-05T04:38:42+00:00","versionOfRecord":[],"versionCreatedAt":"2026-03-18 16:59:15","video":"","vorDoi":"","vorDoiUrl":"","workflowStages":[]},"version":"v1","identity":"rs-8939206","journalConfig":"researchsquare"},"__N_SSP":true},"page":"/article/[identity]/[[...version]]","query":{"redirect":"/article/rs-8939206","identity":"rs-8939206","version":["v1"]},"buildId":"XKTyCvWXoU3ODBz1xrDgd","isFallback":false,"isExperimentalCompile":false,"dynamicIds":[84888],"gssp":true,"scriptLoader":[]}