Covid-19, vagus nerve and phrenic nerve: three sides to the same story

This article aims to prove that there is an intoxication of the vagus and phrenic nerves in cases of covid 19 that lead to symptoms of the disease. First of all, it should be noted that the virus affects the nicotinic receptor a7(a7nAchR), which is the main arm of those peripheral nerves, thus paralyzing the function of both the respiratory system and that of the heart, which is controlled by those nerves. Through our analysis, we support that there is no case of Central Nervous System(CNS) entry, rather the Severe Acute Respiratory Coronavirus 2(SARS-CoV-2) can have distal effects on the CNS, through the microbiome and vagus nerve paralysis. Also, the Angiotensin Converting Enzyme 2(ACE2) receptor upregulation is the key to having milder symptoms. Last but not least, the administration of cholinergic agents, antiepileptics, or even vagus and phrenic nerve stimulation is proposed to be an effective treatment of covid-19.