ICHKI ENDOMETRİOZLARNING PATOMORFOLOGIK ASPEKTLARI

Xamroqulov T.Z, Badriddinov O.U, Umaraliyev A.A
2025 · doi:10.5281/zenodo.14874944 · W6893182277
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The study performed clinical and morphologic examinations of 50 women diagnosed with adenomyosis, assessing age-related development patterns and associated tissue changes. It reports that adenomyosis predominantly developed in the perimenopausal period (after age 40) in the setting of multiple abortions, and that most patients had concomitant multiple leiomyomatous nodules, glandular endometrial hyperplasia, and ovarian fibrocystic transformation or fibrous degeneration. Two morphogenetic variants were described, including cytogenic stroma invasion into the myometrium with endometrial gland formation versus stromal invasion along connective tissue layers without gland formation accompanied by neoangiogenesis. Active and inactive adenomyosis foci coexisted with leiomyomatous nodes in uterine specimens, which the authors interpret as indicating metachronous development, though the paper’s limitation is that it is based on a small, single cohort without broader methodological detail. This paper is centrally about adenomyosis — it characterizes the morphogenetic and pathological variants of adenomyotic lesions and their associated uterine/ovarian findings.

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Abstract

Adenomioz bilan og'rigan 50 nafar ayolning klinik va morfologik tekshiruvi o'tkazildi. Adenomioz asosan perimenopauzal davrda (40 yoshdan keyin) ayollarda ko'p abortlar fonida rivojlanishi aniqlandi. Bemorlarning 90 foizida Adenomioz bir nechta leyomiomatoz tugunlarning rivojlanishi, 60 foizida - bezli endometrial giperplaziya, 100% hollarda - tuxumdonlarning fibrokistik transformatsiyasi yoki tolali degeneratsiyasi bilan kechadi. Adenomiozning ikkita morfogenetik varianti aniqlangan: sitogen stromaning endometriy bezlari shakllanishi bilan miometriyga kirib borishi va aniq neoangiogenez bilan endometrial bezlar hosil bo'lmagan holda biriktiruvchi to'qima qatlamlari bo'ylab sitogen stromaning kirib borishi. Endometrial stroma hujayralarining migratsiyasi va mitogen faolligi, shuningdek, Adenomioz o'choqlari yaqinida eng aniq ifodalangan miometriyning leyomiomatoz transformatsiyasini keltirib chiqaradi. Bachadon namunalarida adenomiozning faol va faol bo'lmagan o'choqlari va leyomiomatoz tugunlarning bir vaqtning o'zida mavjudligi aniqlandi, bu ularning rivojlanish metaxronizmini ko'rsatadi.
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ICHKI ENDOMETRİOZLARNING PATOMORFOLOGIK ASPEKTLARI Authors/Creators Description Adenomioz bilan og'rigan 50 nafar ayolning klinik va morfologik tekshiruvi o'tkazildi. Adenomioz asosan perimenopauzal davrda (40 yoshdan keyin) ayollarda ko'p abortlar fonida rivojlanishi aniqlandi. Bemorlarning 90 foizida Adenomioz bir nechta leyomiomatoz tugunlarning rivojlanishi, 60 foizida - bezli endometrial giperplaziya, 100% hollarda - tuxumdonlarning fibrokistik transformatsiyasi yoki tolali degeneratsiyasi bilan kechadi. Adenomiozning ikkita morfogenetik varianti aniqlangan: sitogen stromaning endometriy bezlari shakllanishi bilan miometriyga kirib borishi va aniq neoangiogenez bilan endometrial bezlar hosil bo'lmagan holda biriktiruvchi to'qima qatlamlari bo'ylab sitogen stromaning kirib borishi. Endometrial stroma hujayralarining migratsiyasi va mitogen faolligi, shuningdek, Adenomioz o'choqlari yaqinida eng aniq ifodalangan miometriyning leyomiomatoz transformatsiyasini keltirib chiqaradi. Bachadon namunalarida adenomiozning faol va faol bo'lmagan o'choqlari va leyomiomatoz tugunlarning bir vaqtning o'zida mavjudligi aniqlandi, bu ularning rivojlanish metaxronizmini ko'rsatadi. Files 46-53.pdf Files (557.2 kB) | Name | Size | Download all | |---|---|---| | md5:e823a6381ac85caddaa5b892ea30310c | 557.2 kB | Preview Download |

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