The Effect of Preoperative Aminophylline on the Recovery Profile After Major Pelvi-abdominal Surgeries: a Randomized Controlled Double-blinded Study

Abstract Background: This study compared the effects of premedication with different doses of aminophylline on the recovery profile after general anesthesia.Methods: 45 patients scheduled for pelvi-abdominal surgeries were divided into 3 groups; Group(C): the patients received 100 ml of IV normal saline, Group (A1): received 2 mg/kg aminophylline IV)and Group(A2): received 4 mg/kg aminophylline(IV)30minutes before induction of general anesthesia . The following data were recorded:demographic data, ASA physical status, duration of anesthesia and surgery, heart rate, mean arterial blood pressure, propofol dose, fentanyl dose ,times to reach BIS (48±2)after induction of anesthesia and to reach 80 after discontinuation of sevoflurane anesthesia,time till recovery of consciousness and to tracheal extubation and to discharge from the post-anesthesia care unit,side effects of aminophylline were also recorded .Results :The time till BIS reach 48±2 was statistically significantly less for the control group compared to group A2 (70.67±22.50 and 106.67±34.77 minutes) for group C and A2 respectively;(p -value =0.00),the time till BIS reached 80 was statistically significantly longer for the control group compared to group A2 (5.6±1.40 and 2.53±1.72 minutes ) for group C and A2 respectively;(p -value =0.00),time for ROC was statistically significantly longer for the control group than group A1 and A2(8.93±0.92, 5.6±2.47 and 4.53±3.33 minutes) for group C, A1 and A2 respectively ; (p -value =0.00 ), the extubation time was statistically significantly longer for the control group being12.4±1.08,7.87±3.27and 6.6±2.47 minutes) for group C, A1 and A2 respectively; (p -value =0.00.Conclusion: Premedication with aminophylline enhanced the recovery profile after pelvi-abdominal surgeries under general anesthesia without cardiovascular complications.Trial registration: Number: NCT04151381, date November 5, 2019, retrospectively