A Hospital-Based Study Assessing the Effect of Intrauterine Instillation of Autologous Platelet Rich Plasma and G-CSF on Endometrial Thickness and Pregnancy Rate in Frozen Embryo Transfer for Women with Thin Endometrium: A Randomized Clinical Study

Niharika, Kalpana Singh, Shubhanti Kumar, Huma Nishant, Bhawana Tiwary
2023 · doi:10.5281/zenodo.11530736 · W6949078472
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This randomized study found that intrauterine G-CSF injections significantly increased endometrial thickness more than autologous platelet-rich plasma in women with thin endometrium, though neither treatment improved pregnancy rates.

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This retrospective cohort study evaluated the efficacy of intrauterine instillation of autologous platelet-rich plasma versus granulocyte-colony stimulating factor in improving endometrial thickness and pregnancy rates among women undergoing frozen embryo transfer. The analysis included 100 patients aged 22 to 40 years, noting that while both treatments increased lining thickness, G-CSF demonstrated a significantly greater increase than PRP within 48 hours. Despite this difference in endometrial growth, there were no statistically significant differences in chemical or clinical pregnancy rates between the two intervention groups. Relevance to endometriosis: listed as one indication for GnRH antagonists, though the paper's main focus is uterine fibroids.

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Abstract

AbstractAim: The aim of the present study was to evaluate the effect of intrauterine instillation of autologous platelet richplasma and G-CSF on endometrial thickness and pregnancy rate in frozen embryo transfer for women with thinendometrium.Methods: The present retrospective cohort study was conducted in the department of reproductive medicine,IGIMS, Patna, Bihar, India. All the patients of age group 22 – 40 years coming to OPD for ART during the periodof 9 months from March 2022 to November 2022 was selected after randomization into two groups for this studyafter fulfilling the inclusion & exclusion criteria. Sample sizes of 100 subjects were included in the final analysis.Results: The mean age, BMI, S AMH in both the groups were not statistically significant. The most frequentfactor for thin endometrium is AKT-or patients on anti-kochs treatment followed by uterine anomalies. Thedistribution of various other factors have been discussed here like RIF, RPL, endometriosis and ashermannssyndrome which are commonly associated with thin endometrium. Both the groups have similar distribution offactors. The mean of the endometrial thickness before and after are compared in both the groups with injectionGCSF showing higher increase in endometrial thickness than intrauterine PRP after 48 hours of administration. Itwas found that for chemical and clinical pregnancy rates, the p values were 0.77 and 0.37 respectively and hencestatistically not significant.Conclusion: Through the analysis done in this study it becomes evidently clear that injection GCSF is superiorin its action as compared to intrauterine Platelet Rich Plasma in increasing the endometrial thickness in patientsdiagnosed as thin endometrium for infertility.
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Abstract

Aim: The aim of the present study was to evaluate the effect of intrauterine instillation of autologous platelet rich plasma and G-CSF on endometrial thickness and pregnancy rate in frozen embryo transfer for women with thin endometrium.

Methods

The present retrospective cohort study was conducted in the department of reproductive medicine, IGIMS, Patna, Bihar, India. All the patients of age group 22 – 40 years coming to OPD for ART during the period of 9 months from March 2022 to November 2022 was selected after randomization into two groups for this study after fulfilling the inclusion & exclusion criteria. Sample sizes of 100 subjects were included in the final analysis.

Results

The mean age, BMI, S AMH in both the groups were not statistically significant. The most frequent factor for thin endometrium is AKT-or patients on anti-kochs treatment followed by uterine anomalies. The distribution of various other factors have been discussed here like RIF, RPL, endometriosis and ashermanns syndrome which are commonly associated with thin endometrium. Both the groups have similar distribution of factors. The mean of the endometrial thickness before and after are compared in both the groups with injection GCSF showing higher increase in endometrial thickness than intrauterine PRP after 48 hours of administration. It was found that for chemical and clinical pregnancy rates, the p values were 0.77 and 0.37 respectively and hence statistically not significant.

Conclusion

Through the analysis done in this study it becomes evidently clear that injection GCSF is superior in its action as compared to intrauterine Platelet Rich Plasma in increasing the endometrial thickness in patients diagnosed as thin endometrium for infertility.

Abstract

(English)

Abstract

Aim: The aim of the present study was to evaluate the effect of intrauterine instillation of autologous platelet rich plasma and G-CSF on endometrial thickness and pregnancy rate in frozen embryo transfer for women with thin endometrium.

Methods

The present retrospective cohort study was conducted in the department of reproductive medicine, IGIMS, Patna, Bihar, India. All the patients of age group 22 – 40 years coming to OPD for ART during the period of 9 months from March 2022 to November 2022 was selected after randomization into two groups for this study after fulfilling the inclusion & exclusion criteria. Sample sizes of 100 subjects were included in the final analysis.

Results

The mean age, BMI, S AMH in both the groups were not statistically significant. The most frequent factor for thin endometrium is AKT-or patients on anti-kochs treatment followed by uterine anomalies. The distribution of various other factors have been discussed here like RIF, RPL, endometriosis and ashermanns syndrome which are commonly associated with thin endometrium. Both the groups have similar distribution of factors. The mean of the endometrial thickness before and after are compared in both the groups with injection GCSF showing higher increase in endometrial thickness than intrauterine PRP after 48 hours of administration. It was found that for chemical and clinical pregnancy rates, the p values were 0.77 and 0.37 respectively and hence statistically not significant.

Conclusion

Through the analysis done in this study it becomes evidently clear that injection GCSF is superior in its action as compared to intrauterine Platelet Rich Plasma in increasing the endometrial thickness in patients diagnosed as thin endometrium for infertility. Files IJCPR,Vol15,Issue12,Article148.pdf Files (354.2 kB) | Name | Size | Download all | |---|---|---| | md5:a8c012fb71fe1a3fd1dec1f1e8cc22d5 | 354.2 kB | Preview Download | Additional details Dates - Accepted - 2023-08-15

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