The pharmacological mechanisms of Sophoraflavescens in the treatment of atopic dermatitis based on pharmacology network strategy

Background: Network pharmacology explores the protective mechanism of Sophoraflavescens on atopic dermatitis (AD). Methods With the help of the Traditional Chinese Medicine System Pharmacology Technology Platform (TCMSP) and the Swiss target prediction database, the effective ingredients and potential target information of the active ingredients of Sophoraflavescens were obtained, and the human gene database (GeneCards) software was used to screen out the target genes related to atopic dermatitis. Using network pharmacology to explore possible molecular mechanisms. Results A total of 38 active ingredients and 508 corresponding targets of Sophoraflavescens were screened out, of which the core target is PAR-2. Sophoraflavescens and cetirizine can significantly improve the degree of inflammatory cell infiltration in AD model mice, reduce pruritus symptoms and pathological damage, and reduce the levels of PGE2, CGRP, LTB4 and SP. Inhibit the expression of PAR-2 and the downstream receptor TrK-A protein. Conclusions Sophoraflavescens and its components can affect AD pruritus by inhibiting the PAR-2 signaling pathway.