The Coagulation Analysis of Reveals Novel Biomarkers for Neonatal Hyperbilirubinemia in Full Term Newborn

Background: The coagulation test is used to evaluate in various diseases. Little is known about correlation between the coagulation test and neonatal hyperbilirubinemia . The aim of the study was to determine the neonatal coagulation analysis value in infants with neonatal hyperbilirubinemia as reliable markers. Methods: : All newborns were born and inpatients in the newborn wards of the Chengdu Second People’s Hospital. Measurement of serum bilirubin was done to diagnose hyperbilirubinemia. All neonates involved were full term of either gender without any significant illness or major congenital malformations. Data were collected from newborns who had neonatal hyperbilirubinemia and healthy in Chengdu Second People’s Hospital. Prothrombin time(PT), Thrombin time(TT), Fibrinogen(Fbg), activated partial thromboplastin time(APTT), and calculated international normalized ration(INR) values were recorded. Linear relationship between INR and level of total bilirubin and indirect bilirubin were analyzed by linear regression. The receiver operating curve(ROC) and the area under the curve(AUC) were made evaluated. Results: : In this case-control study, the mean PT, APTT level were significant higher in the infants with hyperbilirubinemia group compared to the healthy infants. We found the positive correlation between INR and total bilirubin(R=0.3327; P<0.0001). Furthermore, there was also significant positive correlation between INR and indirect bilirubin(R=0.3402; P<0.0001). Meanwhile, INR in neonates with hyperbilirubinemia significantly achieved an AUC of 0.800(95% CI=0.6288-0.9712, cutoff value 1.060, specificity71.43%, and sensitivity 80.00%). Conclusions: : PT, APTT were significant high in neonatal hyperbilirubinemia group. Correlation were observed between the INR and neonatal hyperbilirubinemia. Importantly, the study revealed INR as novel biomarkers for diagnosis of neonatal hyperbilirubinemia in full term newborn.