Comorbid masks of endometriosis

Mekan R. Orazov, Viktor E. Radzinsky, Evgeny D. Dolgov
In: Clinical review for general practice · 2025 · pp. 6–11 · doi:10.47407/kr2025.6.9.00667 · W7154686563
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This paper reviews the poorly understood disease entity of endometriosis, its rising incidence, and its significant underestimation of associated atypical conditions and comorbidities, along with therapeutic strategies.

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This clinical review examines the significant challenge of underestimating atypical conditions and comorbidities associated with endometriosis, which is projected to affect up to one billion women of fertile age globally. The authors highlight modern nosological associations between endometriosis and various comorbidities, emphasizing the need to recognize atypical algological symptoms for accurate diagnosis. They propose pathogenetically substantiated therapeutic strategies, specifically mentioning dienogest, to manage these complex presentations effectively. This paper is centrally about endometriosis — specifically focusing on its comorbidities and atypical symptom profiles in a general practice context.

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Abstract

Endometriosis still remains one of the most interesting but poorly understood disease entities in the world. The current epidemiological research data demonstrate that the endometriosis incidence rate will soon become somewhat of a pandemic and will affect up to 1 billion of fertile age women on the globe. At the same time, one of the main problems of endometriosis at present is underestimation of the endometriosis-associated atypical conditions and comorbidities. In this regard, it is important to consider modern, proven nosological associations of endometriosis with other comorbidities and atypical algological symptoms, as well as to note modern strategies for the effective and pathogenetically substantiated disease therapy.
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Abstract

Endometriosis still remains one of the most interesting but poorly understood disease entities in the world. The current epidemiological research data demonstrate that the endometriosis incidence rate will soon become somewhat of a pandemic and will affect up to 1 billion of fertile age women on the globe. At the same time, one of the main problems of endometriosis at present is underestimation of the endometriosis-associated atypical conditions and comorbidities. In this regard, it is important to consider modern, proven nosological associations of endometriosis with other comorbidities and atypical algological symptoms, as well as to note modern strategies for the effective and pathogenetically substantiated disease therapy.

Keywords

endometriosis, atypical symptoms, comorbidity, pathogenetic therapy, dienogest. For citation: Orazov M.R., Radzinsky V.E., Dolgov E.D. Comorbid masks of endometriosis. Clinical review for general practice. 2025; 6 (9): 6–11 (In Russ.). DOI: 10.47407/kr2025.6.9.00667 All accepted articles publish licensed under a Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

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