Electrochemically Deposited Polypyrrole–Glycine Coatings Incorporating Gentamicin on Magnesium Alloys: A Multifunctional Strategy for Enhanced Implant Durability and Biocompatibility

Electrochemically Deposited Polypyrrole–Glycine Coatings Incorporating Gentamicin on Magnesium Alloys: A Multifunctional Strategy for Enhanced Implant Durability and Biocompatibility | Research Square window.SnipcartSettings = { analytics: { enabled: false } }; (function() { var accessVector = localStorage.getItem('access_vector') || ''; window.dataLayer = window.dataLayer || []; if (accessVector) { window.dataLayer.push({ user: { profile: { profileInfo: { snid: accessVector } } } }); } })(); (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-K279D39R'); Browse Preprints In Review Journals COVID-19 Preprints AJE Video Bytes Research Tools Research Promotion AJE Professional Editing AJE Rubriq About Preprint Platform In Review Editorial Policies Our Team Advisory Board Help Center Sign In Submit a Preprint Cite Share Download PDF Research Article Electrochemically Deposited Polypyrrole–Glycine Coatings Incorporating Gentamicin on Magnesium Alloys: A Multifunctional Strategy for Enhanced Implant Durability and Biocompatibility Nithishkumar M, Mohan Raj R, Raj V This is a preprint; it has not been peer reviewed by a journal. https://doi.org/ 10.21203/rs.3.rs-6568423/v1 This work is licensed under a CC BY 4.0 License Status: Posted Version 1 posted You are reading this latest preprint version Abstract Orthopedic surgeries are often complicated by infections like osteomyelitis, challenging treatment outcomes. Traditional methods, including systemic antibiotics and surgery, are inadequate, leading to prolonged treatment and increased morbidity. Magnesium (Mg) and its composites are promising implant materials due to their biodegradability and compatibility with bone. However, their rapid degradation in physiological conditions require corrosion-resistant surface modifications. Surface coatings, such as polymeric coatings, improve the mechanical and biological properties of Mg-based implants. Additionally, drug delivery systems like gentamicin-loaded coatings offer targeted infection control and bone healing. This study explores the formation of magnesium oxide (MgO) on magnesium alloys through electrodeposition, followed by the electrochemical polymerization of polypyrrole (PPy) and glycine (Gly), with subsequent loading of gentamicin sulfate (GS) to develop multifunctional surface coatings. Characterization by AT-FTIR, XRD, FE-SEM, and EDX confirms the coatings' formation and properties. These coatings show excellent mechanical strength, corrosion resistance, antimicrobial effects, and biocompatibility. In vitro, PPy-Gly-3-coated MgO composites promote excellent osteoblast adhesion and proliferation. Magnesium alloys Polypyrrole (PPy) Gentamicin sulfate (GS) Biocompatibility Corrosion resistance Full Text Additional Declarations No competing interests reported. Cite Share Download PDF Status: Posted Version 1 posted You are reading this latest preprint version Research Square lets you share your work early, gain feedback from the community, and start making changes to your manuscript prior to peer review in a journal. As a division of Research Square Company, we’re committed to making research communication faster, fairer, and more useful. We do this by developing innovative software and high quality services for the global research community. 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Also discoverable on Platform About Our Team In Review Editorial Policies Advisory Board Help Center Resources Author Services Accessibility API Access RSS feed Manage Cookie Preferences © Research Square 2026 | ISSN 2693-5015 (online) Privacy Policy Terms of Service Do Not Sell My Personal Information {"props":{"pageProps":{"initialData":{"identity":"rs-6568423","acceptedTermsAndConditions":true,"allowDirectSubmit":true,"archivedVersions":[],"articleType":"Research Article","associatedPublications":[],"authors":[{"id":453854595,"identity":"966df346-9022-4901-9abc-88b5288708e4","order_by":0,"name":"Nithishkumar M","email":"","orcid":"","institution":"Periyar University","correspondingAuthor":false,"prefix":"","firstName":"Nithishkumar","middleName":"","lastName":"M","suffix":""},{"id":453854596,"identity":"7442d13a-d9ce-4ec8-82a0-f01dbe82165b","order_by":1,"name":"Mohan Raj R","email":"","orcid":"","institution":"Periyar University","correspondingAuthor":false,"prefix":"","firstName":"Mohan","middleName":"Raj","lastName":"R","suffix":""},{"id":453854597,"identity":"913000ec-8b58-49bc-adf0-c8f1c0ea7d9f","order_by":2,"name":"Raj V","email":"data:image/png;base64,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","orcid":"","institution":"Periyar University","correspondingAuthor":true,"prefix":"","firstName":"Raj","middleName":"","lastName":"V","suffix":""}],"badges":[],"createdAt":"2025-05-01 01:23:08","currentVersionCode":1,"declarations":"","doi":"10.21203/rs.3.rs-6568423/v1","doiUrl":"https://doi.org/10.21203/rs.3.rs-6568423/v1","draftVersion":[],"editorialEvents":[],"editorialNote":"","failedWorkflow":false,"files":[{"id":83018519,"identity":"bbd05222-92b6-4456-81aa-d352c4ac3f39","added_by":"auto","created_at":"2025-05-19 06:54:23","extension":"pdf","order_by":1,"title":"","display":"","copyAsset":false,"role":"manuscript-pdf","size":1705109,"visible":true,"origin":"","legend":"","description":"","filename":"NithishkumarPeriyarUniversityManuscript.pdf","url":"https://assets-eu.researchsquare.com/files/rs-6568423/v1_covered_380bfa0f-f4d1-45f9-8a65-7f10926f1ecd.pdf"}],"financialInterests":"No competing interests reported.","formattedTitle":"Electrochemically Deposited Polypyrrole–Glycine Coatings Incorporating Gentamicin on Magnesium Alloys: A Multifunctional Strategy for Enhanced Implant Durability and Biocompatibility","fulltext":[],"fulltextSource":"","fullText":"","funders":[],"hasAdminPriorityOnWorkflow":false,"hasManuscriptDocX":false,"hasOptedInToPreprint":true,"hasPassedJournalQc":"","hasAnyPriority":false,"hideJournal":true,"highlight":"","institution":"","isAcceptedByJournal":false,"isAuthorSuppliedPdf":true,"isDeskRejected":"","isHiddenFromSearch":false,"isInQc":false,"isInWorkflow":false,"isPdf":true,"isPdfUpToDate":true,"isWithdrawnOrRetracted":false,"journal":{"display":true,"email":"[email protected]","identity":"researchsquare","isNatureJournal":false,"hasQc":true,"allowDirectSubmit":true,"externalIdentity":"","sideBox":"","snPcode":"","submissionUrl":"/submission","title":"Research Square","twitterHandle":"researchsquare","acdcEnabled":true,"dfaEnabled":false,"editorialSystem":"","reportingPortfolio":"","inReviewEnabled":false,"inReviewRevisionsEnabled":true},"keywords":"Magnesium alloys, Polypyrrole (PPy), Gentamicin sulfate (GS), Biocompatibility, Corrosion resistance","lastPublishedDoi":"10.21203/rs.3.rs-6568423/v1","lastPublishedDoiUrl":"https://doi.org/10.21203/rs.3.rs-6568423/v1","license":{"name":"CC BY 4.0","url":"https://creativecommons.org/licenses/by/4.0/"},"manuscriptAbstract":"\u003cp\u003eOrthopedic surgeries are often complicated by infections like osteomyelitis, challenging treatment outcomes. Traditional methods, including systemic antibiotics and surgery, are inadequate, leading to prolonged treatment and increased morbidity. Magnesium (Mg) and its composites are promising implant materials due to their biodegradability and compatibility with bone. However, their rapid degradation in physiological conditions require corrosion-resistant surface modifications. Surface coatings, such as polymeric coatings, improve the mechanical and biological properties of Mg-based implants. Additionally, drug delivery systems like gentamicin-loaded coatings offer targeted infection control and bone healing. This study explores the formation of magnesium oxide (MgO) on magnesium alloys through electrodeposition, followed by the electrochemical polymerization of polypyrrole (PPy) and glycine (Gly), with subsequent loading of gentamicin sulfate (GS) to develop multifunctional surface coatings. Characterization by AT-FTIR, XRD, FE-SEM, and EDX confirms the coatings' formation and properties. 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