Hormonal dysfunctions of early pregnancy loss

Endocrine disorders contribute to the pathology of approximately 8% to 12% of recurrent pregnancy losses. Because embryo attachment and early implantation are controlled by the local hormonal milieu, endocrine-related pregnancy failures are likely to occur during early pregnancy. Endocrine abnormalities have to be detected by examination and questioning. Investigations and treatment of these conditions are not consensual. Thyroid disorders, luteal phase defects, polycystic ovary syndrome, hyperprolactinemia and diabetes are the endocrine abnormalities most commonly associated to RPL. Moreover, elevated androgen levels and some endocrinological aspect of endometriosis are factors that seem to participate in the endocrinological pathology of recurrent pregnancy loss. In the present article, we review reproductive implications of the most common endocrine disease with special interest for recurrent pregnancy loss.