Alarelin and low dose tibolone therapy for infertile patients with endometriosis

Objective:To study the role of Alarelin plus low dose tibolone in the treatment of endometriosis.Methods:Fourly infertile patients with endometriosis were randomly divided into two goups.The patients in experimental group (n=20) received Alarelin 150μg/d and tibolone 1.25mg/d,and those in control group(n=20)received Alarelin 150μg/d alone.Results:Serum E2,P,FSH and LH levels were suppressed in all patients,and the positive rates of serum AEMAb and CA125 dropped markedly. Most patients showed significant improvement in clinical symptoms and signs.The pregnancy rate was 55% in experimental group and 45% in control group within 6 months of ceasing treatment,and there was no significant difference between the two groups(P0.05).Hypoestrogenic side effect occurred in 85% of the patients in control group but did not happened in experimental group(P0.05).Conclusion:Alarelin plus low dose tibolone has good curative efficacy with little side effect in the treatment of endometriosis.