In Vivo Antitumor Efficacy of 17-AAG Loaded PMMA in a Multiple Myeloma Patient-Derived Xenograft Mouse Model

Abstract Multiple myeloma (MM) is a monoclonal malignancy characterized by abnormal proliferation of plasma cells. Its main clinical symptoms are osteolytic damage, severe bone pain, spinal instability, and pathological fracture and are collectively referred to as multiple myeloma bone disease (MMBD). Due to its good biomechanical properties and fast curing, polymethylmethacrylate (PMMA) bone cement is widely used for bone repair after MMBD surgery. However, whether drug-loading PMMA can inhibit tumor growth and angiogenesis has not been reported. Here, we report that 17-AAG-loaded PMMA bone cement inhibits MM growth in vivo and suppresses tumor diffusion to peripheral tissues. 17-AAG-loaded PMMA promotes MM apoptosis by downregulating Bax and active Caspase-3.