Systemic Immune-Inflammation Index and serum albumin predict prognosis in rectal cancer patients undergoing curative resection

Background: Systemic nutrition and inflammation have been reported to be associated with the prognosis of various cancers. The aim of this study is to explore the predictive value of systemic immune-inflammation index (SII) and serum albumin in postoperative prognosis for patients with rectal cancer(RC) who received curative resection. Methods: : A total of 184 eligible RC patients were included in this retrospective study. X-tile software was used to determine the optimal cut-off values for SII and serum albumin. The relationship between serum albumin/SII and clinicopathological parameters was analyzed. The effects of serum albumin and SII on overall survival (OS) were assessed by univariate and multivariate Cox proportional hazards model analysis and Kaplan-Meier curves. Results: : The ideal preoperative cut-off points of NLR, PLR, and OPNI were 2.5, 133.3, and 39.5, respectively. Multivariate Cox regression analysis identified that the lymphocyte (P =0.011), Serum albumin (P=0.010), SII (P =0.012) and tumor diameter (P=0.032) were significant prognostic markers for OS. The median OS in the Serum albumin-low and Serum albumin-high groups was 22 months and and not observed (P < 0.001), and that in the SII-high and SII-low groups was 15 months and not observed (P < 0.001), respectively. Conclusions: : SII and serum albumin could be feasible and promising biomarkers for prognosis in RC patients who received curative resection.