How to reduce a risk of venous thromboembolism while taking combined oral contraceptives

The review presents data on the evolution of combined oral contraceptives (COCs), related most frequent and dangerous side effects including venous thromboembolism (VTE). The issue of VTE upon administration of COCs is highlighted, and the risks of such complication in patients receiving hormonal contraception are determined. The issues of the basic demands of women choosing COCs are considered as well as current opportunities to meet such requests by using novel drug groups with a high profile of efficacy and safety. Particular cases of optimal COCs choice for patients with specific comorbidities such as obesity, hirsutism, seborrhea, alopecia, acne, polycystic ovary syndrome (PCOS), fibrocystic mastopathy, endometriosis as well as in case of gynecological surgical interventions are analyzed. The options of contraceptive therapy are proposed by taking into account individual female wishes (lack of weight gain, decreased libido, etc.). About the Authors V. O. BitsadzeRussian Federation Victoria O. Bitsadze – MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health Scopus Author ID: 6506003478. Researcher ID: F-8409-2017. 2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991 J. Kh. Khizroeva Russian Federation Jamilya Kh. Khizroeva – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health Scopus Author ID: 57194547147. Researcher ID: F-8384-2017. 2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991 A. G. Solopova Russian Federation Antonina G. Solopova – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health Scopus Author ID: 6505479504. Researcher ID: Q-1385-2015. 2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991 M. V. Kvaratskheliia Russian Federation Margaret V. Kvaratskheliia – MD, Medical Resident, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health 2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991 D. Yu. Zabolotnaya Russian Federation Diana Yu. Zabolotnaya – MD, Medical Resident, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health 2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991 Z. Xiaoxia Russian Federation Zhou Xiaoxia – MD, Medical Resident, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health 2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991 M. V. Tretyakova Russian Federation Maria V. Tretyakova – MD, PhD, Obstetrician-Gynecologist, Assistant, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health 2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991 V. I. Tsibizova Russian Federation Valentina I. Tsibizova – MD, PhD, Obstetrician-Gynecologist, Research Laboratory of Operative Gynecology, Institute of Perinatology and Pediatrics; Physician, Department of Functional and Ultrasound Diagnostics 2 Akkuratova Str., Saint Petersburg 197341 N. R. Gashimova Russian Federation Nilufar R. Gashimova – MD, Postgraduate Student, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health 2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991 K. N. Grigoreva Russian Federation Kristina N. Grigoreva – MD, Assistant, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health 2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991 M. A. Gileva Russian Federation Maria A. Gileva – MD, Clinical Resident, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children's Health 2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991 A. S. Shkoda Russian Federation Andrey S. Shkoda – MD, Dr Sci Med, Professor, Chief Physician 2/44 Salyama Adilya Str., Moscow 123423 J.-Ch. Gris France Jean-Christophe Gris – MD, Dr Sci Med, Professor, Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health; Professor of Haematology, Head of the Laboratory of Haematology, Faculty of Biological and Pharmaceutical Sciences, Montpellier University and University Hospital of Nîmes, France; Foreign Member of RAS, Moscow, Russia. Scopus Author ID: 7005114260. Researcher ID: AAA-2923-2019. 2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991, Russia; 163 Rue Auguste Broussonnet, Montpellier 34090, France A. D. Makatsariya Russian Federation Alexander D. Makatsariya – MD, Dr Sci Med, Academician of RAS, Professor, Head of the Department of Obstetrics, Gynecology and Perinatal Medicine, Filatov Clinical Institute of Children’s Health; Vice-President of the Russian Society of Obstetrican-Gynecologists (RSOG); Honorary Doctor of the Russian Federation; Emeritus Professor of the University of Vienna. Scopus Author ID: 57222220144. Researcher ID: M-5660-2016. 2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

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(In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.422 JATS XML This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.